Flavonoids from Tephrosia Calophylla

Abstract

Two new flavanones, (2S)-5-hydroxy-7,4′-di-O-(γ,γ-dimethylallyl)flavanone (1) and 6-hydroxy-E-3-(2,5-dimethoxybenzylidine)-2′,5′-dimethoxyflavanone (2), together with three known compounds, tephrowatsin C, afrormosin and kaempferol 3-O-β-D-glucopyranoside were isolated from the roots of Tephrosia calophylla. The structures of 1 and 2 were established by extensive 2D NMR spectral studies.

Flavonoids and their glycosides, including anthocyanins

“…448 Root extracts of Tephrosia calophylla (Leguminosae) yielded the first example of a di-O-prenylated flavanone (623), which is a derivative of (2S)-naringenin. 450 This journal is ª The Royal Society of Chemistry 2011…”

Comparative toxicity assessment of three Tephrosia species on Artemia salina and animal cell lines

“…Two fl avonones namely (2S)-5-hydroxy-7,4'-di-O-(gamma,gammadimethylallyl) flavanone and 6-hydroxy-E-3-(2,5dimethoxybenzylidine)-2',5'-dimethoxyflavanone; tephrowatsin C, afrormosin, a benzil, calophione A and three coumestan derivatives like tephcalostan B, C and D were also reported to be isolated from the roots of Tephrosia calophylla. [14][15][16] Tephrosia purpurea Pers. is a pan tropical coastal shrub.…”

Natural Products from the Genus Tephrosia

“…Fifty-one flavans, 43 – 93 , were isolated from twenty-three species of the genus Tephrosia, i.e. , T. obovata , T. villosa , T. madrensis , T. nitens , T. watsoniana , T. hildebrandtii , T. falciformis , T. hamiltonii , T. quercetorum , T. leiocarpa , T. spinosa , T. maxima , T. emoroides , T. tepicana , T. crassifolia , T. strigosa , T. pumila , T. calophylla , T. vogelii , T. apollinea , T. candida , T. purpurea and T. fulvinervis [1,2,4,6,13,22,23,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63].…”

“…The genus Tephrosia , belonging to the Leguminosae family, is a large pantropical genus of more than 350 species, many of which have important traditional uses [1,2]. Phytochemical investigations have revealed the presence of glucosides, rotenoids, isoflavones, chalcones, flavanones, flavanols, and prenylated flavonoids [1,2,3,4,5,6,7,8,9] of chemotaxonomic importance in the genus [10]. Moreover, bioactivity has been studied extensively, indicating that chemical constituents and extracts of the genus Tephrosia exhibited diverse bioactivities, such as insecticidal [11], antiviral [12], antiprotozoal [13], antiplasmodial [14] and cytotoxic [15] activities.…”