Flavonoids from Italian Multifloral Honeys Reduce the Extracellular Ferricyanide in Human Red Blood Cells

Fiorani, Mara; Accorsi, Augusto; Blasa, Manuela; Diamantini, Giuseppe; Piatti, Elena

doi:10.1021/jf061602q

Cited by 49 publications

(51 citation statements)

References 45 publications

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“…Our results show the anti-inflammatory role of acacia honey by its ability to down regulate the level of TNF α in PC-3 cell line. This support the anti-inflammatory role of honey as previously described [11]. The level of IL-1β was observed to be high in our present study.…”

Section: Discussionsupporting

confidence: 93%

“…It is a promising antitumor agent with pronounced anti-metastatic and anti-angiogenic effects [10], antibacterial, anti-inflammatory, immune-stimulant, antiulcer and wound/burn healing effects [11]. Various signaling pathways, including stimulation of tumor necrosis factor-alpha (TNF α) release, inhibition of cell proliferation, induction of apoptosis and cell cycle arrest, as well as inhibition of lipoprotein oxidation, mediate the beneficial effects exerted by honey and its major components such as chrysin and other flavonoids [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Acacia Honey Modulates Cell Cycle Progression, Pro-inflammatory Cytokines and Calcium Ions Secretion in PC-3 Cell Lines

et al. 2012

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Background: Prostate cancer is the most common malignancy in men and the second leading cause of cancer-related deaths. Honey has been proven to have a potentiality of being among the functional foods by both in vivo and in vitro studies. Aim:This study was primarily designed to provide evidence on the apoptotic role of acacia honey on PC-3 cell line. Methods:MTT and mitotic index assay were used to determine the anti-proliferative effects. Cell cycle analysis was conducted on flow cytometer using propidium iodide. Expression of pro-inflammatory cytokines [TNF α and IL 1β] and prostate specific antigen were determined by ELISA kits. Calcium ion level was analyzed by colorimetric method. Results:Our results show the anti-proliferative effects of acacia honey on NIH/3T3 and PC-3 cell lines with the IC 50 of 3.7 and 1.9% [v/v] respectively with simultaneous increase in the secretion of calcium ion and down regulation of prostate specific antigen. Significant [p < 0.05] dose-dependent modulation of G0/G1 phase was observed as compared with the control. However, there was an inverse relationship between TNF-α and IL-1β with latter being up regulated. Mitotic index of PC-3 cells decreased as the concentration of honey increases. Conclusion:Apoptotic role of acacia honey on PC-3 cell line may be due to modulation of G0/G1 phase, proinflammatory cytokines, calcium ions secretion and down regulation of prostate specific antigen in vitro.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Acacia Honey Modulates Cell Cycle Progression, Pro-inflammatory Cytokines and Calcium Ions Secretion in PC-3 Cell Lines

et al. 2012

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“…Moreover, some phenolics show antioxidant properties (16), due to chemical structures, that decrease the risk of oxidative diseases in humans (11). Honey contains phenolics collected by honeybees from plants along with nectar (17). Honey includes the phenolic acids and flavonoids such as protocatechuic acid, pcoumaric acid, and myricetin (18).…”

Section: Introductionmentioning

confidence: 99%

Total phenolic contents and antioxidant activities of Korean domestic honey from different floral sources

Baek

Kim

Baik

et al. 2015

Food Sci Biotechnol

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Total phenolic contents and antioxidant activities of 7 Korean domestic honey varieties and fractions from different floral sources were determined. Extracts of 7 varieties of honey were fractionated in the sequence of nhexane, chloroform, ethyl acetate, n-butanol, and water. The ethyl acetate fraction (EAF) of all 7 honey varieties retained the majority of the antioxidant activity and the total phenolic content. The antioxidant activities of the EAF from Korean raisin honey were 52.74 and 24.44 mg of vitamin C equivalents/g of dry fraction based on ABTS and DPPH radicals, respectively. Total EAF phenolic contents of 7 honey varieties ranged from 5.27 to 29.17 mg of gallic acid equivalents/g of dry fraction. High correlation coefficients between total phenolic contents and antioxidant activities indicated that phenolic compounds were the major components responsible for the antioxidant activities of honey.

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“…While hemoglobin levels it was found that the tested natural omani Honey, Natural Turkish Honey and Commercial Honey increased level up to 3 gm/dL. Honey administration trends to increase in Hb level may be due to honey as an anti-anemic and immunestimulant agent 20 .…”

Section: Physiological Effect Of Different Honey In Vivo On Micementioning

confidence: 90%

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2016

IJPSR

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ABSTRACT:The preliminary phytochemical evaluation and effect of Honey on Hematological parameters were investigated. Preliminary phytochemical screening was carried out to determine the presence of various bioactive constituents through different Tests. The Antimicrobial study of different Honey in combination with synergistics was carried out on selective microorganisms through well diffusion method. The effect of Honey on hemoglobin, WBC, Blood Sugar and weight loss was studied on swiss albino male mice under controlled conditions for 21 days. The Highest percentage of coumarins (+++), Resins (+++) were found in all the types of tested Honey among the different phytochemicals Screened. However the absence of carboxylic carbon and tannins were noticed during the study. The antimicrobial studies along with different synergistics shown significant results like Natural Omani Honey exerted 36mm zone of inhibition against S.aureus, while Turkish honey found to be more antimicrobial against P. aeruginosa (40mm). In the present study on Hematological and physiological parameters it was observed that increase in WBC % with greatest significance, among all the tested Honey with Natural Turkish Honey we found more increase of WBC % upto 30%. These findings provides the information about the traditional use of Honey along with various food additives triggers more beneficial in treating various human ailments like controlling from microbial diseases, improving WBC to increase immunity etc. further evaluation needs further evaluation and identification active principles are required for pharmacological preparations.

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Flavonoids from Italian Multifloral Honeys Reduce the Extracellular Ferricyanide in Human Red Blood Cells

Cited by 49 publications

References 45 publications

Acacia Honey Modulates Cell Cycle Progression, Pro-inflammatory Cytokines and Calcium Ions Secretion in PC-3 Cell Lines

Acacia Honey Modulates Cell Cycle Progression, Pro-inflammatory Cytokines and Calcium Ions Secretion in PC-3 Cell Lines

Total phenolic contents and antioxidant activities of Korean domestic honey from different floral sources

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