Flavonoids from Physospermum acteaefolium

Bencheraiet, Reguia; Kabouche, Ahmed; Kabouche, Zahia; Touzani, Rachid; Jay, Maurice

doi:10.1007/s10600-012-0281-6

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…The BLB fraction had the highest ABTS •+ scavenging potential (10.0 ± 0.54 μg/mL) compared to the BLM fraction (18.0 ± 0.35 μg/mL) and HDEO (41.0 ± 0.70 μg/mL). The observed activity for both fractions could be attributed to their TP and TF contents [ 21 , 22 ]. Despite the fact that no phenolic compounds were detected in the GC/MS analysis of the HDEO, the moderate antioxidant potential recorded for the essential oil could be attributed to its terpenoidal content.…”

Section: Resultsmentioning

confidence: 99%

Uncovering the Chemical Composition and Biological Potentials of Bupleurum lancifolium Hornem. from Jordan

Al-Bataineh,

Abu-Orabi,

Shannag

et al. 2024

Molecules

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The current study was designed to uncover the chemistry and bioactivity potentials of Bupleurum lancifolium growing wild in Jordan. In this context, the fresh aerial parts obtained from the plant material were subjected to hydrodistillation followed by GC/MS analysis. The main components of the HDEO were γ-patchoulene (23.79%), β-dihydro agarofuran (23.50%), α-guaiene (14.11%), and valencene (13.28%). Moreover, the crude thanolic extract was partitioned to afford two main major fractions, the aqueous methanol (BLM) and butanol (BLB). Phytochemical investigation of both fractions, using conventional chromatographic techniques followed by careful inspection of the spectral data for the isolated compounds (NMR, IR, and UV-Vis), resulted in the characterization of five known compounds, including α-spinasteryl (M1), ethyl arachidate (M2), ethyl myristate (M3), quercetin-3-O-β-d-glucopyranosyl-(1-4”)-α-L-rhamnopyranosyl (B1), and isorhamnetin-3-O-β-d-glucopyranosyl-(1-4”)-α-L-rhamnopyranosyl (B2). The TPC, TFC, and antioxidant activity testing of both fractions and HDEO revealed an interesting ABTS scavenging potential of the BLB fraction compared to the employed positive controls, which is in total agreement with its high TP and TF contents. Cytotoxic evaluation tests revealed that BLM had interesting cytotoxic effects on the normal breast cell line MDA-MB-231 (ATCC–HTB-26) and the normal dermal fibroblast (ATCC® PCS-201-012) and normal African green monkey kidney Vero (ATCC-CCL-81) cell lines. Despite both the BLB and BLM fractions showing interesting AChE inhibition activities (IC50 = 217.9 ± 5.3 µg/mL and 139.1 ± 5.6 µg/mL, respectively), the HDEO revealed an interestingly high AChE inhibition power (43.8 ± 2.7 µg/mL) that far exceeds the one observed for galanthamine (91.4 ± 5.2 µg/mL). The HDEO, BLM, and BLB exhbitied no interesting antimicrobial activity against Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, or Pseudomonas aeruginosa.

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Section: Resultsmentioning

confidence: 99%

Uncovering the Chemical Composition and Biological Potentials of Bupleurum lancifolium Hornem. from Jordan

Al-Bataineh,

Abu-Orabi,

Shannag

et al. 2024

Molecules

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“…aureum, B. multinerve), which was found earlier in B. falcatum subsp. cernuum [15]; cacticin (19, B. scorzonerifolium), which was observed in B. rotundifolium [16] and B. spinosum [17]; and quercetin-3-O-E-glucopyranosyl-(1o2)-E-glucopyranoside (16, B. longifolium subsp. aureum, B. triradiatum) and hyperoside (18, B. scorzonerifolium); which were also identified for the first time in the genus Bupleurum.…”

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confidence: 99%

“…Phenylpropanoids were represented by various derivatives of caffeic acid (8), e.g., mono-and disubstituted esters of quinic acid [2-(10), 3-(9), 4-(11), and 5-O-caffeylquinic (12); 1,3-(13) and 3,5-di-O-caffeylquinic acids (17)] and glycerin [1-O-caffeyl-(6) and 1,3-di-O-caffeylglycerin (7)]. The compound 3-O-caffeylquinic acid (9) was found previously in B. falcatum [18], B. komarovianum [3], B. longiradiatum, and B. scorzonerifolium [18]; 5-O-caffeylquinic acid (12), in B. falcatum [18]; 1-O-caffeylglycerin (6), in B. chinense [19] .…”

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confidence: 99%