Flavonoids from Scutellaria cordifrons and S. phyllostachya roots

Siddikov, G. U.; Yuldashev, M. P.; Batirov, É. Kh.; Abdullaev, Sh. V.

doi:10.1007/s10600-006-0121-7

Cited by 4 publications

(2 citation statements)

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“…While synthetic drugs can take effect quickly and efficiently, their long-term use can trigger harmful changes in the body. As a result, it is crucial to extract physiologically active compounds from plants, synthesize new derivatives, and develop effective medications to address this issue [1].…”

Section: Introduction 1relevance Of the Topicmentioning

confidence: 99%

The study of the phenolic substances of the aerial part of the plant “Kokamaron” (Scutellaria Leptosiphon Juz.)

Muradov,

Fayzullaev,

Ergashev

et al. 2023

E3S Web Conf.

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In the article, the extraction of secondary metabolites, i.e., flavonoids, of the Scutellaria leptosiphon Juz plant, belonging to the Scutellaria family growing in Uzbekistan, and their chemical structure was studied. The methods of extraction, fractionation, thin-layer chromatography, column chromatography, paper chromatography, and quality reaction methods were used during the research. Also, the structure of flavonoids was analyzed by physical methods - ultraviolet (UV), infrared (IR), nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The aerial part of Scutellaria leptosiphon Juz collected from the mountains of the Sherobod district of Surkhandarya region (Uzbekistan) was studied for the first time and it was found that it contains baicalein, wogonin and baicalein-7-O-β-D-glucopyranoside. Based on the results of chemical reactions and UV, IR, 1N NMR spectrum data, the structure of 3 flavonoid substances isolated from the examined plant was determined to be Baicalein (5,6,7-trihydroxyflavone), Vogonin (5,7-dihydroxy-8-methoxyflavone) and Baicalein-7-O-β-D-glucopyronazide substances. The results and conclusions of the research conducted on the isolation and chemical structure of the secondary metabolites of the S. Leptosiphon plant belonging to the Scutellaria family growing in the flora of Uzbekistan were presented.

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Section: Introduction 1relevance Of the Topicmentioning

confidence: 99%

The study of the phenolic substances of the aerial part of the plant “Kokamaron” (Scutellaria Leptosiphon Juz.)

Muradov,

Fayzullaev,

Ergashev

et al. 2023

E3S Web Conf.

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“…The obtained compounds were purified by fractional crystallization from various solvents and rechromatography over silica gel and polyamide. These flavonoids were identified using chemical transformations (acid and base hydrolysis); IR, UV, PMR, and mass spectral data; comparison of physicochemical constants with the literature values; and direct comparison with flavonoid samples isolated by us from other Scutellaria species [11][12][13][14]. The flavonoids norwogonin, oroxylin A, quercetin, and hispidulin from the aerial part and wogonin, chrysin-7-methylglucuronide, oroxyloside, wogonoside, (±)-5,2c-dihydroxy-6,6c,7-trimethoxyflavanone, and (-)-5,2c-dihydroxy-6,6c,7,8-tetramethoxyflavanone from the roots were isolated from this plant for the first time.…”

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Flavonoids from the Aerial Part and Roots of Scutellaria adenostegia

Karimov

Ботиров

2015

Chem Nat Compd

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Skullcap (Scutellaria L.) is a plant genus of the family Lamiaceae that comprises about 350 species that are broadly distributed in temperate, subtropical, and tropical zones of Europe, North America, and eastern Asia [1,2]. Thirty two Scutellaria species grow in Uzbekistan and are used in folk medicine to treat epilepsy, allergies, neurosis, hypertonia, and other diseases [2, 3].Pharmacological studies confirmed that extracts and individual flavonoids of Scutellaria plants (baicalin, baicalein, wogonin, chrysin, etc.) possessed antitumor, antiviral, hepatoprotective, antioxidant, anti-inflammatory, anticonvulsive, and antibacterial properties [4][5][6][7][8]. Therefore, phytochemical studies of plants of this genus are critical.The flavonoids chrysin, apigenin, baicalein, 2c-methoxychrysin, 5,2c,6c-trihydroxy-7,8-dimethoxyflavone (viscidulin II), and 5,2c,6c-trihydroxy-6,7,8-trimethoxyflavone were isolated earlier from roots and the aerial part of Scutellaria adenostegia Briq. collected in Talas valley and in the Pamir-Alai range [9]. Plants collected in Shakhimardan contained apigenin, apigenin-7-O-glucoside, apigenin-7-O-glucuronide, baicalein, baicalin, dihydroscutellarein (carthamidin), carthamidin-7-O-glucuronide, luteolin, luteolin-7-O-glucuronide, scutellarein, and scutellarin [10]. We studied flavonoids from the aerial part and roots of S. adenostegia growing in the vicinity of Turakurgan, Namangan Province, Republic of Uzbekistan, in order to discover new sources of biologically active flavonoids.Column chromatography over silica gel of the EtOAc and BuOH fractions of the EtOH extract of the aerial part isolated oroxylin A, apigenin, norwogonin, hispidulin, scutellarein, scutellarin, and quercetin. The CHCl 3 , EtOAc, and BuOH fractions of the EtOH extract of the roots afforded (±)-5,2c-dihydroxy-6,7,6c-trimethoxyflavanone, (-)-5,2c-dihydroxy-6,7,8,6c-tetramethoxyflavanone, chrysin, wogonin, apigenin, chrysin-7-O-E-D-methylglucuronide, oroxyloside, and wogonoside [11]. The obtained compounds were purified by fractional crystallization from various solvents and rechromatography over silica gel and polyamide. These flavonoids were identified using chemical transformations (acid and base hydrolysis); IR, UV, PMR, and mass spectral data; comparison of physicochemical constants with the literature values; and direct comparison with flavonoid samples isolated by us from other Scutellaria species [11][12][13][14]. The flavonoids norwogonin, oroxylin A, quercetin, and hispidulin from the aerial part and wogonin, chrysin-7-methylglucuronide, oroxyloside, wogonoside, (±)-5,2c-dihydroxy-6,6c,7-trimethoxyflavanone, and (-)-5,2c-dihydroxy-6,6c,7,8-tetramethoxyflavanone from the roots were isolated from this plant for the first time.The change of flavonoid composition of S. adenostegia as a function of habitat was probably due to soil, climate, and ecological factors. Like for many Scutellaria species, compounds with an unsaturated ring B dominated the flavonoids of S. adenostegia [11,15].

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