Flavonoids from stem bark of akway (Drymis beccariana Gibs) and theirs antimalarial properties

Abstract

Akway (Drimys beccariana, Gibbs) is a plant endemic to Papua highlands contained in Manokwari. D. beccariana is used for traditional malaria treatment in West Papua. The methanol extract of stem bark of D. beccariana showed antimalarial activity against Plasmodium falciparum parasites, in vitro. Methanol extract of D. beccariana is partitioned between water and n-hexane (1:9), and ethyl acetate. Furthermore, ethyl acetate extract was separated through several combination of chromatography techniques on silica gel, resulting in three known compounds (1-3). The chemical structures of compounds (1-3) were identified based on IR, UV/Vis, 1H NMR and 13C NMR, and MS data as 5,3’-dihydroxy-7,4’-dimethoxyflavone (1), 5,7-dihydroxy-4’-methoxyflavone (2), and 5-hydroxy-7,3’,4’-trimethoxyflavone (3). Compounds 1-3 showed strong antiplasmodium against 3D7 strain of P. falciparum with IC50 values of 0.002, 0.005, and 0.001 micro Molar, respectively. This result indicates that stem bark of D. beccariana is a promising source of antimalarial agents, and merits further investigation.

Phytochemical Constituents of Aquilaria malaccensis Leaf Extract and Their Anti-Inflammatory Activity against LPS/IFN-γ-Stimulated RAW 264.7 Cell Line

“…From the leaves of A. malaccensis , eight known compounds ( 1 – 8 ) were obtained and structurally characterized (Figure ). Through comparing the NMR spectroscopic data of the isolated compounds with literature values, the compounds were recognized as epifriedelanol ( 1 ), 5-hydroxy-7,4′-dimethoxyflavone ( 2 ), luteolin-7,3′,4′-trimethyl ether ( 3 ), , luteolin 7,4′- dimethyl ether ( 4 ), , acacetin ( 5 ), aquilarinenside E ( 6 ), iriflophenone-2- O -α- l -rhamnopyranoside ( 7 ), and Iriflophenone 3- C -β-glucoside ( 8 ). , The above-mentioned compounds were obtained from the species of A. malaccensis for the first time.…”

Phytochemical Screening of Sorghum (Sorghum Sp) with Thin Layer Chromatography Method

“…The cardioprotective effect of flavonoids as a food source in addition to the cardioprotective properties of flavonoids which have antiproliferation properties against cancer cells (Ayza, Balasubramanian, & Berhe, 2020;Ferenczyova, Kalocayova, & Bartekova, 2020) and have antioxidant, antiparasitic and anti-bacterial roles. Because of its antioxidant properties, flavonoids are often added in cosmetics because of their antibacterial properties (Herlina, Rudiana, Julaeha, & Parubak, 2019;Mead & McNair, 2006).…”

Plant Extracts as a Source of Natural Products with Potential Antimalarial Effects: An Update from 2018 to 2022

“…Phytochemical investigation revealed that 5,3′-dihydroxy-7,4′-dimethoxyflavone ( 1 ), 5,7-dihydroxy-4′-methoxyflavone ( 2 ), and 5-hydroxy-7,3′,4′-trimethoxyflavone ( 3 ) had strong antiplasmodium activity against the 3D7 strain of P. falciparum, with IC 50 values of 2 nM, 5 nM, and 1 nM, respectively. The compounds were isolated from the stem bark of Drymis beccariana Gibbs (Winteraceae) and indicate a potential source of antimalarial agents [ 94 ]. Silica gel chromatography, HPLC, ultraviolet-visible spectroscopy (UV), IR, NMR, and MS/MS were used for compound isolation.…”