Flavonoids from the leaves and twigs of Knema elegans

Flavonoids and other constituents of plants from the genus Knema (Myristicaceae) and their pharmacological studies: An updated review

“…and could be utilized to distinguish Knema plant species. [37] O (32), which exhibited an IC50 of 12.0 and 4.3 µM in the presence of bovine serum albumin (BSA) as an inhibitor of DNA polymerase and 2.7 and 1.2 µM IC50 in the absence of BSA, making the compounds the most potent DNA polymerase β inhibitors at the time. Both compounds reduced the number of viable cells by at least 30% when 9 µM was employed for 6 h in an otherwise harmless quantity of bleomycin.…”

“…Myristinin A (31) and 7,4′dihydroxy-3′-methoxyflavan (38) were also documented from the leaves and stems of K. glauca Warb. [37] Notably, (31) and (32) were cyclooxygenase enzyme inhibitors and cytotoxic to Vero cells at IC50 values of 17.7 and 13.6 µg/mL, respectively. [39] K. globularia Warb.…”