Flavonoids in the Treatment of Neuropathic Pain

Rao, Prashant N; Mainkar, Ojas; Bansal, Nitin; Rakesh, Neal; Haffey, Paul Ryan; Urits, Ivan; Orhurhu, Vwaire; Kaye, Alan D.; Urman, Richard D.; Gulati, Amitabh; Jones, Mark

doi:10.1007/s11916-021-00959-y

Cited by 19 publications

(10 citation statements)

References 45 publications

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“…Other potentially effective pharmacological agents for the treatment of neuropathic pain include nerve growth antagonists, oxcarbazepine, flavonoids, selective serotonin reuptake inhibitors (SSRIs) and NMDA antagonists [ 239 , 240 , 241 , 242 , 243 , 244 ] Despite unclear or poor results of initial research concerning these agents, their therapeutic potential for neuropathic pain should be deeply evaluated in future studies.…”

Section: Treatment Strategies For Neuropathic Painmentioning

confidence: 99%

Diagnosis and Management of Neuropathic Pain in Spine Diseases

Bielewicz

Kamieniak

Szymoniuk

et al. 2023

JCM

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Neuropathic pain is generally defined as a non-physiological pain experience caused by damage to the nervous system. It can occur spontaneously, as a reaction to a given stimulus, or independently of its action, leading to unusual pain sensations usually referred to as firing, burning or throbbing. In the course of spine disorders, pain symptoms commonly occur. According to available epidemiological studies, a neuropathic component of pain is often present in patients with spinal diseases, with a frequency ranging from 36% to 55% of patients. Distinguishing between chronic nociceptive pain and neuropathic pain very often remains a challenge. Consequently, neuropathic pain is often underdiagnosed in patients with spinal diseases. In reference to current guidelines for the treatment of neuropathic pain, gabapentin, serotonin and norepinephrine reuptake inhibitors and tricyclic antidepressants constitute first-line therapeutic agents. However, long-term pharmacologic treatment often leads to developing tolerance and resistance to used medications. Therefore, in recent years, a plethora of therapeutic methods for neuropathic pain have been developed and investigated to improve clinical outcomes. In this review, we briefly summarized current knowledge about the pathophysiology and diagnosis of neuropathic pain. Moreover, we described the most effective treatment approaches for neuropathic pain and discussed their relevance in the treatment of spinal pain.

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Section: Treatment Strategies For Neuropathic Painmentioning

confidence: 99%

Diagnosis and Management of Neuropathic Pain in Spine Diseases

Bielewicz

Kamieniak

Szymoniuk

et al. 2023

JCM

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“…Rutin, along with several other flavonoids, reduces free radical-mediated oxidative stress and increases levels of antioxidant enzymes in the nerve tissue of diabetic animals, thus helping alleviate diabetic neuropathy [19] . Epigallocatechin-3gallate (EGCG), a flavonoid found in green tea, was found to be effective at reducing thermal hyperalgesia in neuropathic pain models [18] . Wei et al [21] also showed that by reducing the expression of oxidative stress pathways, this compound may enhance neuronal survival after peripheral nerve injury.…”

Section: Antioxidants and Chronic Painmentioning

confidence: 99%

“…Flavonoids are polyphenolic compounds that have both antioxidant and anti-inflammatory properties. Quercetin is a type of flavonoid that has been shown to reduce both inflammatory and neuropathic pain through its inhibition of oxidative stress [16][17][18] . This flavonoid's analgesic properties are partly due to the activation of the Nrf2/HO-1 pathway, which protects cells from oxidative stress [16] .…”

Section: Antioxidants and Chronic Painmentioning

confidence: 99%

Role of antioxidants in itch treatment: lessons learned from pain management

Soares¹,

Mahmoud²,

Yosipovitch³

2023

Itch

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Chronic pain and chronic pruritus are both debilitating conditions that cause a significant burden to patients. Oxidative stressdriven by an imbalance between reactive oxygen species and antioxidants-has been shown to play a role both in pain disorders and conditions in which chronic itch is a prominent symptom. Antioxidants can be useful in treating oxidative stress-driven diseases and have shown promise in treating chronic pain conditions such as fibromyalgia and osteoarthritis. However, their role in treating pruritus and pruritic conditions such as psoriasis and atopic dermatitis remains unclear. Many of the current treatments for chronic itch are costly, associated with side effects, and have limited efficacy. Therefore, further controlled studies exploring antioxidants as a potential therapeutic option for chronic pruritus are warranted.

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“…This production can be reduced, for example, by cannabinoids and/or flavonoids, with a therapeutically relevant effect, i.e. reduced pain intensity in patients with hyperalgesia (Henshaw et al 2021;Rao et al 2021).…”

Section: Peripheral Nerve Injury -An Example Of Wound Healing In High...mentioning

confidence: 99%

Autoimmunity, cancer and COVID-19 abnormally activate wound healing pathways: critical role of inflammation

Gál

Brábek

Holub

et al. 2022

Histochem Cell Biol

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Recent evidence indicates that targeting IL-6 provides broad therapeutic approaches to several diseases. In patients with cancer, autoimmune diseases, severe respiratory infections [e.g. coronavirus disease 2019 (COVID-19)] and wound healing, IL-6 plays a critical role in modulating the systemic and local microenvironment. Elevated serum levels of IL-6 interfere with the systemic immune response and are associated with disease progression and prognosis. As already noted, monoclonal antibodies blocking either IL-6 or binding of IL-6 to receptors have been used/tested successfully in the treatment of rheumatoid arthritis, many cancer types, and COVID-19. Therefore, in the present review, we compare the impact of IL-6 and anti-IL-6 therapy to demonstrate common (pathological) features of the studied diseases such as formation of granulation tissue with the presence of myofibroblasts and deposition of new extracellular matrix. We also discuss abnormal activation of other wound-healing-related pathways that have been implicated in autoimmune disorders, cancer or COVID-19.

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Flavonoids in the Treatment of Neuropathic Pain

Cited by 19 publications

References 45 publications

Diagnosis and Management of Neuropathic Pain in Spine Diseases

Diagnosis and Management of Neuropathic Pain in Spine Diseases

Role of antioxidants in itch treatment: lessons learned from pain management

Autoimmunity, cancer and COVID-19 abnormally activate wound healing pathways: critical role of inflammation

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