Flavonoids mitigate neurodegeneration in aged <i>Caenorhabditis elegans</i> by mitochondrial uncoupling

Cho, In‐Jeong; Song, Hyun-Ok; Cho, Jeong Hoon

doi:10.1002/fsn3.1956

Cited by 33 publications

(21 citation statements)

References 56 publications

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“…Low concentration of a mitochondrial uncoupler induces mild ROS production and PQQ extends the lifespan by increasing endogenous ROS levels 89 . Quercetin, one of the antioxidant polyphenols, is also known to protect neural and cardiac tissues through its mild mitochondrial uncoupling function 90 – 92 . ROS can act as essential signaling molecules to promote metabolic health and longevity 93 .…”

Section: Discussionmentioning

confidence: 99%

Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence

et al. 2022

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The aim of this study was to investigate the effects of pyrroloquinoline quinone (PQQ), an oxidoreductase cofactor, on the H2O2-induced premature senescence model in HEI-OC1 auditory cells and to elucidate its mechanism of action in vitro. Cells were treated with PQQ for 1 day before H2O2 (100 μM) exposure. Mitochondrial respiratory capacity was damaged in this premature senescence model but was restored in cells pretreated with PQQ (0.1 nM or 1.0 nM). A decrease in mitochondrial potential, the promotion of mitochondrial fusion and the accelerated movement of mitochondria were all observed in PQQ-pretreated cells. The protein expression of sirtuin 1 (SIRT1) and peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) were significantly decreased under H2O2 exposure while they were increased with PQQ pretreatment, and PGC-1α acetylation was significantly decreased. In conclusion, PQQ has a protective effect on the premature senescence model of HEI-OC1 auditory cells and is associated with the SIRT1/PGC-1α signaling pathway, mitochondrial structure, and mitochondrial respiratory capacity.

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Section: Discussionmentioning

confidence: 99%

Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence

et al. 2022

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“…On the other hand, GM potentially enhances the bioavailability of phenolic metabolites to the host (92,93). Benefits of polyphenols and their metabolites in prevention of cognitive decline associated with its anti-inflammatory properties were reported previously (94)(95)(96)(97). For example, gallic acid, which is a bacterial-derived metabolite of anthocyanins, was shown to decrease Aβ deposition, reduce neuroinflammation and oxidative stress in brain of AD mice (98).…”

Section: Polyphenolsmentioning

confidence: 89%

Nutrition, Gut Microbiota, and Alzheimer's Disease

Romanenko

Kholin

Koliada³

et al. 2021

Front. Psychiatry

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Nutrition is known to play an important role in the pathogenesis of Alzheimer's disease. Evidence is obtained that the gut microbiota is a key player in these processes. Dietary changes (both adverse and beneficial) may influence the microbiome composition, thereby affecting the gut-brain axis and the subsequent risk for Alzheimer's disease progression. In this review, the research findings that support the role of intestinal microbiota in connection between nutritional factors and the risk for Alzheimer's disease onset and progression are summarized. The mechanisms potentially involved in these processes as well as the potential of probiotics and prebiotics in therapeutic modulation of contributed pathways are discussed.

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“…[54] Mitochondria uncoupling ability took part in keeping membrane potential in aged C. elegans with flavonoid treatment. [55] The natural compound urolithin A has also been reported to trigger mitophagy in C. elegans and decrease the proportion of dysfunctional mitochondria that accumulate over time, resulting in a longer lifespan. [56] Taken together, SAC might enhance function and maintain mitochondria in linear morphology via mitochondrial biogenesis and fusion in aged model organisms.…”

Section: Discussionmentioning

confidence: 99%

S‐Allylcysteine Ameliorates Aging Features via Regulating Mitochondrial Dynamics in Naturally Aged C57BL/6J Mice

Chen

Chang

Lin

et al. 2022

Molecular Nutrition Food Res

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Scope: S-Allylcysteine (SAC) is the most abundant organosulfur molecule derived from aged garlic. The effects ofSAC on improving Aging in naturally aged C57BL/6J male mice and mitochondrial dynamics in Caenorhabditis elegans and its underlying mechanisms is evaluated. Methods and Results: When mice have attained reproductive senescence at 60 weeks of age, SAC is supplemented to 0.05% and 0.2% into their normal diet for 12 weeks. The results show that SAC could significantly improve the level of hepatic optic atrophy 1 (OPA1) mRNA, which is a key factor for mitochondrial fusion, and consequently elevated the mitochondrial biogenesis-related proteins sirtuin 1 (SIRT1) and peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1𝜶), thus ameliorating oxidative stress, such as malondialdehyde (MDA) in the liver and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in urine. Among the biochemical markers of aging, SAC significantly reduces liver galactosidase 𝜷1 (GLB1) and senescence-associated 𝜷-galactosidase (SA-𝜷gal), which are induced by replicative senescence. The mitochondria with green fluorescent protein (GFP)-tagged transgenic strain SJ4103 C. elegans is incubated with 5 or 50 µM SAC, and SAC treated groups maintain the linear morphology of mitochondria. Conclusion: SAC regulates mitochondrial dynamics and ameliorated aging to a significant degree. This study also confirms that mitochondrial dynamics are a promising target for screening materials to combat aging and as a direction for anti-aging product development.

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Flavonoids mitigate neurodegeneration in aged Caenorhabditis elegans by mitochondrial uncoupling

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 33 publications

References 56 publications

Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence

Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence

Nutrition, Gut Microbiota, and Alzheimer's Disease

S‐Allylcysteine Ameliorates Aging Features via Regulating Mitochondrial Dynamics in Naturally Aged C57BL/6J Mice

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