Flavonoids of Carthamus tinctorius Flowers

Куркин, В. А.; Kharisova, A. V.

doi:10.1007/s10600-014-0983-z

Cited by 10 publications

(4 citation statements)

References 7 publications

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“…The possible mechanisms involved in the transformation of these compounds are assumed in Figure 6 . The results were consistent with previous reports in that glucoside could be hydrolyzed to aglycone under various conditions, including high temperature during stir-fry processing [ 43 , 50 , 51 ]. In addition, luteolin-7- O - β - d -glucoside has been documented to possess significant anti-inflammatory and antiviral effects [ 52 , 53 ].…”

Section: Resultssupporting

confidence: 93%

The Potential Transformation Mechanisms of the Marker Components of Schizonepetae Spica and Its Charred Product

Liu

Ying

et al. 2020

Molecules

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Schizonepetae Spica (SS) is commonly used for treating colds, fevers, bloody stool and metrorrhagia in China. To treat colds and fevers, traditional Chinese medicine doctors often use raw SS, while to treat bloody stool and metrorrhagia, they usually use Schizonepetae Spica Carbonisata (SSC; raw SS processed by stir-frying until carbonization). However, there have been limited investigations designed to uncover the mechanism of stir-fry processing. In the present study, a method combining gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) was developed for the comprehensive analysis of the chemical profiles of SS and SSC samples. Principal component analysis of the GC-MS data demonstrated that there were 16 significant differences in volatile compounds between the SS and SSC samples. The simultaneous quantification of six nonvolatile compounds was also established based on HPLC, and remarkable differences were found between the two products. These changes were probably responsible for the various pharmacological effects of SS and SSC as well as the observed hepatotoxicity. Finally, the mechanisms could be rationalized by deducing possible reactions involved in the transformation of these marker components. This work reports a new strategy to reveal the chemical transformation of SS during stir-fry processing.

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Section: Resultssupporting

confidence: 93%

The Potential Transformation Mechanisms of the Marker Components of Schizonepetae Spica and Its Charred Product

Liu

Ying

et al. 2020

Molecules

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“…In the course of further study, the following substances were also isolated: (2S)-4′,5-dihydroxyl-6,7-di-O- β -D-glucopyranosyl flavanone, 6-hydroxy kaempferol 3-O- β -D-glucoside, 6-hydroxykaempferol 3-O- β -D-rutinoside, 6-hydroxykaempferol 6,7-di-O- β -D-glucoside, and 6-hydroxyquercetin 3,6,7-tri-O- β -D-glucoside [ 34 ]. Other ingredients isolated from aqueous extracts of flower petals were quinochalcones (cartormin, isosafflomin C, precarthamine, safflomin B, safflomin C, safflor yellow A, safflor yellow B, and tinctormin [ 35 ]) and flavonoids (azaleatin (3,7,3′,4′-tetrahydroxy-5-methoxyflavone), saffloroside (3,7,3′,4′-tetrahydroxy-5-methoxyflavone 7-O- β -D-glucopyranoside), 5-O-methylluteolin [ 36 , 37 ], cinaroside (5,7,3′,4′-tetrahydroxyflavone 7- O - β -D-glucopyranoside) [ 36 ], and 6-hydroxykaempferol-3- O - β -D-glucoside-7- O - β -D-glucuronide [ 38 ]).…”

Section: Chemical Composition Of Safflower Green Parts and Flowersmentioning

confidence: 99%

Bioactive Substances in Safflower Flowers and Their Applicability in Medicine and Health-Promoting Foods

Adamska

Biernacka

2021

International Journal of Food Science

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Safflower flowers (Carthamus tinctorius) contain many natural substances with a wide range of economic uses. The most famous dye isolated from flower petals is hydroxysafflor A (HSYA), which has antibacterial, anti-inflammatory, and antioxidant properties. This review is aimed at updating the state of knowledge about their applicability in oncology, pulmonology, cardiology, gynecology, dermatology, gastrology, immunology, and suitability in the treatment of obesity and diabetes and its consequences with information published mainly in 2018-2020. They were also effective in treating obesity and diabetes and its consequences. The issues related to the possibilities of using HSYA in the production of health-promoting food were also analyzed.

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“…Safflower is a dried stigma of the petals of Carthamus tinctorius L. and is classified as a potent natural antioxidant. Through several studies, it has been reported to have antioxidant activity in preventing/treating age-related diseases and oxidative stress such as neuronal and cardiovascular disorders , as well as cancer. , This is presumably because it contains chemical compounds such as quercetin (QU) , and luteolin (LU). , Due to their potential to contribute a hydrogen atom to the DPPH radical, these bioactive components demonstrated the synergistic impact of a high radical scavenging activity. However, there are a few limitations caused by the original nature, such as low solubility in water resulting in reduced skin permeation abilities. − In addition, the stratum corneum, which is the outermost layer of the skin, acts as a penetration barrier by blocking the delivery of active ingredients into the skin.…”

Section: Introductionmentioning

confidence: 99%

“…13,14 This is presumably because it contains chemical compounds such as quercetin (QU) 15,16 and luteolin (LU). 17,18 Due to their potential to contribute a hydrogen atom to the DPPH radical, these bioactive components demonstrated the synergistic impact of a high radical scavenging activity. However, there are a few limitations caused by the original nature, such as low solubility in water resulting in reduced skin permeation abilities.…”

Section: Introductionmentioning

confidence: 99%

Development of Solid Lipid Nanoparticle-Loaded Polymeric Hydrogels Containing Antioxidant and Photoprotective Bioactive Compounds of Safflower (Carthamus tinctorius L.) for Improved Skin Delivery

et al. 2023

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Safflower (Carthamus tinctorius L.) is a potent natural antioxidant because of active compounds such as quercetin (QU) and luteolin (LU). These components prevent damage to the skin caused by free radicals from UV rays. However, due to the poor solubility and transdermal permeation, the effectiveness of the compounds in showing their activity was limited. In this study, we develop solid lipid nanoparticle (SLN)-based hydrogel formulations to enhance the solubility and penetration of two bioactive compounds found in safflower petals extract (SPE). The hot emulsification-ultrasonication method was used to produce SLNs, and to obtain high antioxidant activity, 100% v/v ethanol was used in the extraction procedure. The results showed that this approach could encapsulate >80% of both QU and LU. Moreover, Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD) spectra indicated that most of the QU and LU were trapped in a lipid matrix and dispersed homogeneously at the molecular level, increasing the solubility. Additionally, SLN-hydrogel composites are able to release two lipophilic bioactive compounds for 24 h, which also demonstrated increased skin retention and penetrability of the QU and LU up to 19-fold. In vitro blood biocompatibility showed that no hemolytic toxicity was observed below 500 μg/mL. Accordingly, the formulation was considered safe for use. Sun protective factor (SPF) test shows a value above 15, showing an excellent promising application as the photoprotective agent to prevent symptoms associated with photoinduced skin aging.

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Flavonoids of Carthamus tinctorius Flowers

Abstract: glucopyranoside (safloroside) were isolated from Carthamus tinctorius flowers and characterized by PMR and UV spectroscopy and mass spectrometry.

Cited by 10 publications

References 7 publications

The Potential Transformation Mechanisms of the Marker Components of Schizonepetae Spica and Its Charred Product

The Potential Transformation Mechanisms of the Marker Components of Schizonepetae Spica and Its Charred Product

Bioactive Substances in Safflower Flowers and Their Applicability in Medicine and Health-Promoting Foods

Development of Solid Lipid Nanoparticle-Loaded Polymeric Hydrogels Containing Antioxidant and Photoprotective Bioactive Compounds of Safflower (Carthamus tinctorius L.) for Improved Skin Delivery

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