Flavonoids of Helichrysum compactum and their antioxidant and antibacterial activity

Süzgeç, Sevda; Meriçli, Ali H.; Houghton, Peter J.; Çubukçu, B.

doi:10.1016/j.fitote.2004.12.006

Cited by 76 publications

(39 citation statements)

References 3 publications

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“…In fact, the methanol extract was found to stimulate the growth of this organism in their preliminary activity screening study on the effects of several Turkish spice extracts against this food pathogen. This might be due to the low flavonoid content of H. compactum as reported by Süzgeç et al (2005).…”

Section: Discussionmentioning

confidence: 85%

“…In these studies, several extracts and isolated compounds were reported to possess antimicrobial activity. Chloroform and ethyl acetate extracts from H. compactum flowers were shown to possess antimicrobial activity against B. subtilis, Pseudomonas aeruginosa, S. aureus, E. coli, and Candida albicans (all MIC values were 40 g/mL) (Süzgeç et al, 2005). Nostro et al (2000) reported moderate activity against E. coli for the diethyl ether extract of H. italicum, while the petroleum ether, dichloromethane, dichloromethane-methanol (9:1), and methanol extracts were devoid of such activity.…”

Section: Discussionmentioning

confidence: 99%

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Antimicrobial effect ofHelichrysum plicatumsubsp.plicatum

Demir¹,

Taban

Aslan

et al. 2009

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Antimicrobial effect ofHelichrysum plicatumsubsp.plicatum

Demir¹,

Taban

Aslan

et al. 2009

Pharmaceutical Biology

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“…Vários trabalhos na literatura sugerem a correlação entre as atividades antioxidante e antiinflamatória, ou seja, alguns extratos vegetais reduzem inflamações por eliminar superóxidos conhecidos por participarem do recrutamento de células polimorfonucleares (PMN) presentes em tecidos inflamados (Thambi et al, 2009;Ródenas et al, 2000). Apesar de não ser possível inferir com precisão quais são os compostos responsáveis pela ação antioxidante da fração acetato de etila, os flavonóides devem ser parcialmente responsáveis por esta atividade, tendo em vista os inúmeros trabalhos que relatam as diferentes atividades exibidas por esta classe de compostos, os quais são descritos preponderantemente como potentes antioxidantes (Alves et al, 2007;Furusawa et al, 2005;Suzgeç et al, 2005;Cioffi et al, 2002 …”

Section: Resultsunclassified

Flavonoides e atividade antioxidante em Palicourea rigida Kunth, Rubiaceae

Rosa¹,

Silva²,

Silva³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:A atividade antioxidante, avaliada pelo método DPPH (1,1-difenil-2-picrilidrazila), e o teor em compostos fenólicos totais do extrato bruto metanólico e frações das folhas da espécie Palicourea rigida Kunth, Rubiaceae, foram quantificadas neste trabalho. Apesar da baixa atividade apresentada pelo extrato bruto (500 ppm), a fração acetato de etila apresentou atividade moderada (192 ppm) e o maior teor de fenólicos totais dentre as frações ensaiadas. Assim, a fração acetato de etila foi submetida a procedimentos cromatográficos o que resultou no isolamento dos flavonoides quercetina 3-O-β-D-glicosídeo, quercetina 3-O-soforosídeo e isoraminetina 3-glicosídeo, cujas estruturas foram elucidadas por análise espectroscópica, incluindo RMN (1D e 2D) e comparação com os dados da literatura.Unitermos: Rubiaceae, Palicourea, flavonoides, atividade antioxidante.ABSTRACT: "Flavonoids and antioxidant activity in Palicourea rigida Kunth, Rubiaceae". The antioxidant activity, evaluated by DPPH (1,1-difenil-2-picrilidrazila) method, and the determination of the total phenolic compounds of the crude methanolic extract and fractions of the Palicourea rigida Kunth, Rubiaceae, leaves were quantified in this work. Despite weak activity exhibited by crude extract (500 ppm), the fraction ethyl acetate showed moderate activity (192 ppm), and the largest value for the phenolic compounds among all the assayed fractions. Then, the ethyl acetate fraction was submitted to the chromatography procedures which led to the isolation of the flavonoid quercetin 3-O-D-glicoside, quercetin 3-O-sophoroside and isorhamnetin 3-glicoside, which had the structures elucidated by spectroscopy analysis, including RMN (1D and 2D) and comparison with literature data.

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“…Natural compounds like flavonoids and phenolics are known to have antioxidant property and prevent free radical chain reaction in biological systems and provide additional health benefits [22]. Flavonoids are known as excellent free radical scavenging agents and known to have properties for the management of diabetes and diabetic complications [23][24][25]. Flavonoids also lead to regeneration of pancreatic β-cells, reduce necrosis and degeneration of pancreatic β-cells and thus may be effective in treating hyperglycemia by preventing diabetic complications [26].…”

Section: Discussionmentioning

confidence: 99%

Anti-Hyperglycemic Effect of Different Fractions of Annona Reticulata Leaf

Rout

Kar

Maharana

2016

Asian J Pharm Clin Res

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Context: Several species of the genus Annona were reported to have hypoglycemic properties and this makes Annona reticulata Linn. (Annonaceae) an interesting plant for investigating its anti-hyperglycemic potential.Objective: Different fractions prepared from hydro-alcoholic extract of A. reticulata leave were investigated for their blood glucose lowering effect on Streptozotocin (STZ) induced hyperglycemic rats.Methods: Ethyl acetate, methanol, and residual fractions (at dose level of 100 mg/kg by oral route) prepared from the hydro-alcoholic extract of A. reticulata leave were administered for 14 consecutive days to STZ induced hyperglycemic rats for evaluation of their anti-hyperglycemic potential. Anti-hyperglycemic potential was assessed by observation of a decrease in fasting blood glucose level. Results:The studies revealed that ethyl acetate fraction decreased the blood glucose level of hyperglycemic rats from 447.67 to 234.17 mg/dL and is significant (p<0.001) when compared with diabetic control group. The residual fraction and methanolic fraction decreased blood glucose level from 417.83 to 402.50 mg/dL and 432.33 to 371.67 mg/dL respectively but not significant when compared with the diabetic control group. Standard drug metformin (dose 300 mg/kg) reduced the blood glucose level from 447.33 to 219.50 mg/dL. Discussion: Ethyl acetate fraction at tested dose level was capable not only to control the elevated blood glucose level but also able to attenuate certain secondary parameters associated with STZ induced hyperglycemia. Conclusion:This study suggested that the ethyl acetate fraction prepared from hydro-alcoholic extract of A. reticulata leave exhibit potential antihyperglycemic property in the tested experimental models and should be investigated further.

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Flavonoids of Helichrysum compactum and their antioxidant and antibacterial activity

Cited by 76 publications

References 3 publications

Antimicrobial effect ofHelichrysum plicatumsubsp.plicatum

Antimicrobial effect ofHelichrysum plicatumsubsp.plicatum

Flavonoides e atividade antioxidante em Palicourea rigida Kunth, Rubiaceae

Anti-Hyperglycemic Effect of Different Fractions of Annona Reticulata Leaf

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