Flavonoids of Lagochilus platycalyx

Nasrullaev, F. D.; Makhsudova, B.

doi:10.1007/bf00636587

Cited by 4 publications

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“…Phytochemical studies performed on different Lagochilus species have demonstrated the occurrence of several classes of primary and secondary metabolites. A literature survey revealed that the genus Lagochilus is a rich source of diterpenoids [ 30 , 31 , 32 , 33 ], flavonoids [ 29 , 34 ], phenolic compounds, triterpenoids [ 34 ], iridoid glycosides, lignans, steroids, alkaloids, polysaccharides [ 35 ], volatile, non-volatile and aromatic compounds, lipids, carbohydrates, minerals, vitamins, and others. About 150 secondary metabolites have been reported from all previous classes in the genus.…”

Section: Phytochemical Studiesmentioning

confidence: 99%

“…Lagochilus species are characterized by rich biological activities, such as antioxidant, anti-allergic, and enzyme inhibitory activities due in part to the presence of a diversity of flavonoids and phenolic compounds [ 21 , 27 , 28 , 29 , 40 , 50 , 58 ]. Flavonoids accumulate in different plant parts of the Lagochilus species.…”

Section: Phytochemical Studiesmentioning

confidence: 99%

“…Preliminary biological investigations on Lagochilus components (extracts, fractions, and individual compounds) have indicated their antispasmodic [ 90 ], sedative and hypotensive [ 29 ], psychoactive [ 91 ], and other activities. Lagochilus components may be valuable in the treatment of glaucoma [ 92 ], dermoplasty [ 93 ], hypertension, heart failure, and angina [ 29 , 94 ].…”

Section: Biological Activitiesmentioning

confidence: 99%

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The Genus Lagochilus (Lamiaceae): A Review of Its Diversity, Ethnobotany, Phytochemistry, and Pharmacology

Mamadalieva

Akramov

Wessjohann

et al. 2021

Plants

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The genus Lagochilus (Lamiaceae) is native to Central, South-Central, and Eastern Asia. It comprises 44 species, which have been commonly used as herbal medicines for the treatments of various ailments for thousands of years, especially in Asian countries. This review aims to summarize the chemical constituents and pharmacological activities of species from the genus Lagochilus to unveil opportunities for future research. In addition, we provide some information about their traditional uses, botany, and diversity. More than 150 secondary metabolites have been reported from Lagochilus, including diterpenes, flavonoids, phenolic compounds, triterpenoids, iridoid glycosides, lignans, steroids, alkaloids, polysaccharides, volatile, non-volatile and aromatic compounds, lipids, carbohydrates, minerals, vitamins, and other secondary metabolites. In vitro and in vivo pharmacological studies on the crude extracts, fractions, and isolated compounds from Lagochilus species showed hemostatic, antibacterial, anti-inflammatory, anti-allergic, cytotoxic, enzyme inhibitory, antispasmodic, hypotensive, sedative, psychoactive, and other activities.

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Section: Phytochemical Studiesmentioning

confidence: 99%

Section: Phytochemical Studiesmentioning

confidence: 99%

Section: Biological Activitiesmentioning

confidence: 99%

See 1 more Smart Citation

The Genus Lagochilus (Lamiaceae): A Review of Its Diversity, Ethnobotany, Phytochemistry, and Pharmacology

Mamadalieva

Akramov

Wessjohann

et al. 2021

Plants

View full text Add to dashboard Cite

show abstract

“…[ 6 7 8 ] Previous phytochemical studies revealed the presence of diterpenoids, flavonoids, coumarins, iridoid glycosides and polysaccharides in this genus. [ 6 7 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 ] Pharmacological results indicated that diterpenoids from this genus, including lagochiline and its derivatives, could have the ability of hemostatic. [ 20 25 ]…”

Section: Introductionmentioning

confidence: 99%

A New Lignan Glucoside from Lagochilus ilicifolius

et al. 2015

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Background:The whole herb of Lagochilus ilicifolius has been used as a folk medicine for treating hemostatic, inflammation and ulcer in China. There were only limited reports on its chemical constituents, and no reports on its pharmacology study.Objective:To isolate compounds from the whole herb of L. ilicifolius and evaluate their cytotoxic activity.Materials and Methods:The column chromatographic techniques were used for separating the constituents of the n-butanol-soluble fraction of the 95% ethanol extract from the whole plant of L. ilicifolius. The structures of one new lignan and two known lignans were elucidated on the basis of spectroscopic analyses and comparison with literature data. The cytotoxic activities of these three lignans were evaluated using the MTT-assay against PC12 cell line derived from rat adrenal pheochromocytoma.Results:The new lignan was identified as erythro-1-[(4-O-β-D-glucopyranosyl-3-methoxyl)-phenyl]-2-[(5’-methoxyl)-pinoresinol]-propane-1,3-diol (1), and two known lignans were identified as tortoside C (2) and sisymbrifolin (3). The new lignan exhibited significant cytotoxic activity against PC12 cell line with IC50 value of 1.22 ± 0.03 μmol/L.Conclusions:A new lignan, erythro-1-[(4-O-β-D-glucopyranosyl-3-methoxyl)-phenyl]-2-[(5’-methoxyl)-pinoresinol]-propane-1,3-diol and two known lignans were isolated from the whole herbs of L. ilicifolius. The two known lignans were reported for the first time in the genus Lagochilus. Three lignans were evaluated for in vitro cytotoxic activity. The new lignan showed relatively strong cytotoxicity against PC12 cell line, while sisymbrifolin and tortoside C exibited no cytotoxicity.

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“…In Russian folk medicine, L. inebrians is used to treat allergies, blood clots, skin diseases and hemophilia, and this herb has been listed in the Russian Pharmacopeia as a natural tranquilizer (Ratsch, ). Diterpenoids (Zainutdinov et al ., ; Mavlyankulova et al ., ; Islamov et al ., ; Nurmatova et al ., ), flavonoids (Nasrullaev and Makhsudova, ; Gohari et al , ), triterpenoids (Gohari et al , ) and polysaccharides (Malikova and Rakhimov, ) are the constituents isolated from Lagochilus species. Pharmacological results indicated that diterpenoids from this genus, mainly lagochiline and its derivatives, could have hemostatic abilities (Zainutdinov et al , ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hemostatic and Anti‐inflammatory Activities of Extracts from Different Lagochilus Species in Experimental Animals: Comparison of Different Extractives and Sources

Jiao

Chen

Xiong

et al. 2014

Phytotherapy Research

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Different members of Lagochilus genus have been used in folkloric medicine to treat hemorrhages and inflammation. However, only a few species of them have received scientific attention supporting their efficacy. Here, the hemostatic and antiinflammatory activities of five Lagochilus species were determined and compared by using in vivo assays. The results showed that the extracts of Lagochilus lanatonodus and Lagochilus diacanthophyllus showed better hemostatic activities among five species. The high doses of L. lanatonodus extracts were able to shorten the values of thrombin time, activated partial thromboplastin time and prothrombin time in a rat model. Moreover, the extracts of L. lanatonodus and L. diacanthophyllus showed strong inhibitory effects on the acute phase of inflammation in both xylene-induced ear edema mouse model and carrageenan-induced paw edema rat model. In parallel, the treatment of these extracts modulated the expressions of those inflammatory parameters, that is, nitric oxide, prostaglandin E2 , inducible nitric oxide synthase, malondialdehyde and superoxide dismutase. L. lanatonodus and L. diacanthophyllus showed better hemostatic and antiinflammatory activities in several test models: these results therefore supported the folkloric utilization. L. lanatonodus was found to be the most active Lagochilus species.

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Flavonoids of Lagochilus platycalyx

Cited by 4 publications

References 0 publications

The Genus Lagochilus (Lamiaceae): A Review of Its Diversity, Ethnobotany, Phytochemistry, and Pharmacology

The Genus Lagochilus (Lamiaceae): A Review of Its Diversity, Ethnobotany, Phytochemistry, and Pharmacology

A New Lignan Glucoside from Lagochilus ilicifolius

Evaluation of Hemostatic and Anti‐inflammatory Activities of Extracts from Different Lagochilus Species in Experimental Animals: Comparison of Different Extractives and Sources

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