Flavonoids of some euphorbiaceous plants

Antiproliferative Activity of the Main Constituents from Phyllanthus emblica

“…Although many studies have so far been carried out on the chemical components of P. emblica, [13][14][15][16][17][18] its detailed active principles are generally not well known. This paper deals with the inhibitory activity of 19 together with the 18 main constituents 1-18 isolated previously from P. emblica on the proliferation of B16F10 (murine melanoma), HeLa (human uterine carcinoma), and MK-1 (human gastric adenocarcinoma) cells to determine their roles in the anticancer uses of this plant.…”

“…Elaeocarpusin (10) and putranjivain A (11) were the other two main ellagitannins obtained from the fruit juice. Moreover, seven other tannins and flavonoids, geraniin (12), phyllanemblinins C and E (13 and 14), prodelphinidin B 1 (15), prodelphinidin B 2 (16) (18) were the main phenolic compounds isolated from the branches and leaves of the plant (Figs. 1, 2).…”

“…Among them, the major phenolic compounds corilagin (8) and geraniin (12) as well as hydrolysable tannin elaeocarpusin (10) and condensed tannin prodelphinidins B 1 and B 2 (15,16) showed the highest activity (GI 50 at 2 mg/ml for 12, 15, 16, and 3 mg/ml for 8, 10) against B16F10, while 15 and 16 had the highest inhibitory activity (GI 50 9 mg/ml) against HeLa, and (Ϫ)-epigallocatechin 3-O-gallate (17), known as the active constituent in green tea, showed the highest activity (4 mg/ml) against MK-1.…”

Diterpenoids from the root bark of Jatropha curcas and their cytotoxic activities

“…J. curcas has served globally as a source of lamp oil and soap, and also as a medicinal plant for the treatment of dropsy, paralysis, rheumatism, and certain skin diseases for a long time (Jiangsu New Medicinal College, 1977). Previous investigations on the secondary metabolites of J. curcas had resulted in the isolation of diterpenoids (Naengchomnong et al, 1994(Naengchomnong et al, , 1986Ravindranath et al, 2003Ravindranath et al, , 2004Chianese et al, 2011;Wang et al, 2009;Liu et al, 2012), sesquiterpenoids (Wang et al, 2008), flavonoids (Khafagy et al, 1977;Subramanian et al, 1971), lignans (Li et al, 2010), coumarins (Kong et al, 1996;Mitra et al, 1970;Matsuse et al, 1999) and cyclic peptides (Van den Berg et al, 1995;Auvin et al, 1997) with various biological activities. In order to isolate the minor active compounds, we investigated this plant and obtained three new diterpenoids along with nine known ones from the CHCl 3 extract of the root bark.…”

A new cytotoxic acylated apigenin glucoside fromPhyllanthus emblicaL.

“…The leaves are also used in the treatment of conjunctivitis and bronchitis. Several reports about this plant have shown that the fruits are rich in vitamin C, mucic acid, tannins [2,3], flavanone glycosides [4], phenolic glycosides [5], sesquiterpenoids [6], norsesquiterpenoids [7], phenolic acids [8] and flavonol glycosides [9].…”