Flavonoids, Vascular Function and Cardiovascular Protection

Grassi, Davide; Desideri, Giovambattista; Croce, Giuseppe; Tiberti, Sergio; Aggio, Alberto; Ferri, Claudio

doi:10.2174/138161209787846982

Cited by 171 publications

(190 citation statements)

References 115 publications

(299 reference statements)

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“…Polyphenols, particularly the flavonoids inhibit the atherosclerosis development in animal models. Also, favonols improve the endothelial function, reduce blood pressure and inhibit platelet reactivity (Grassi et al, 2009, Heiss et al, 2010.…”

Section: Resultsmentioning

confidence: 99%

Effect of Lingonberry Extracts on Blood Pressure and Myocardium in Paracetamol Intoxication

Roman¹,

Fărcăş²,

Toma³

2017

BUASVMCN-VM

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In this study we tried to see how (1:1 and 3:1) lingonberry extract act as protective agents of the myocardium and blood pressure in toxicosis induced by paracetamol in rats. Experiments were made on white female Wistar rats, weighing 135 ± 20 g which were divided into 6 groups of 7 animals each: control group (C); Paracetamol treated group (P) -75 mg acetaminophen/100 g bw for 10 days. 1:1 lingonberry hidroalcoholic treated group (Lha), (200 mg/100 g bw (80 µg benzoic acid/100 g bw) for 15 days. 3:1 lingonberry dried extract group (Ld), 100 mg/100 g bw (112 µg benzoic acid/100 g bw), for 15 days. P+Lha (PLha) and P + Ld (PLd) treated group. Blood pressure increases following administration of paracetamol and decreases under treatment with lingonberry extract, more obvious to 3: 1 lingonberry dried extract. Administration of Paracetamol, lingonberry extracts used simple or in combination with Paracetamol does not affect the myocardium histological structure. Histoenzimological there is a slight decrease of SDH activity in the groups P and PLd and an increase in Lha group. CyOx activity is increased in Lha and Ld group. The dried lingonberry extract has no apparent action on the myocardium instead has antihypertensive properties more obvious than the lingonberry alcoholic extract.

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Section: Resultsmentioning

confidence: 99%

Effect of Lingonberry Extracts on Blood Pressure and Myocardium in Paracetamol Intoxication

Roman¹,

Fărcăş²,

Toma³

2017

BUASVMCN-VM

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“…(Corradini et al, 2011). Not all flavonoids are ROS scavengers because some flavonoids, as nucleophiles, trap electrons from the ROS and become a free radical themselves, which then propagate a chain reaction causing a deleterious effect in the cell (Grassi et al, 2009 (Hargrove et al, 2011). The inhibition of enzymes that have a Fe-S cluster has been demonstrated (Mena et al, 2011).…”

Section: Wwwintechopencommentioning

confidence: 99%

Microalgae of the Chlorophyceae Class: Potential Nutraceuticals Reducing Oxidative Stress Intensity and Cellular Damage

Blas-Valdivia¹,

Ortiz-Butrón²,

Ruth³

et al. 2012

Oxidative Stress and Diseases

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“…Epidemiological data continue to support the premise that dietary intake of natural products may improve vascular endothelial dysfunction in both in vivo and in vitro atherosclerotic models (8,9). For example, popular and edible mushrooms have been traditionally used to maintain health, and their components have been used in the prevention and treatment of diseases in many countries, including Korea.…”

Section: Introductionmentioning

confidence: 98%

The n-butanol fraction of Naematoloma sublateritium suppresses the inflammatory response through downregulation of NF-κB in human endothelial cells

et al. 2012

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Abstract. Naematoloma sublateritium (Fr.) P. Karst is a chestnut mushroom that is currently a popular edible fungus in the USA, Japan, China and Korea. Although its therapeutic potential in the treatment of diseases has been demonstrated, the pharmacological effect of N. sublateritium (NS) has been poorly studied. In the present study, we demonstrate for the first time that NS suppresses TNF-α-induced inflammatory response in human umbilical vein endothelial cells. The n-butanol fraction of NS (BFNS) inhibited TNF-α-induced monocyte adhesion to endothelial cells in a dose-dependent manner. The anti-adhesive activity of BFNS correlated with suppressed expression of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, monocyte chemoattractant protein-1 and interleukin-8 at both the mRNA and protein levels. In addition, BFNS dose-dependently decreased the expression of inducible nitrogen oxygen synthase (iNOS) and cyclooxygenase-2 (COX-2). Notably, BFNS significantly regulated the nuclear factor (NF)-κB transcriptional activity that was activated by TNF-α stimulation. When considered together, these results suggest that BFNS inhibits the expression of TNF-α-induced adhesion molecules in addition to regulating the iNOS/COX-2 pathways through the modulation of NF-κB in endothelial cells. In conclusion, we propose that BFNS may be a potential therapeutic agent against vascular inflammation, such as atherosclerosis. IntroductionAtherosclerosis, a cardiovascular disease, is a leading cause of death worldwide and is the result of a complicated inflammatory processes on the inner wall of large blood vessels. Immune responses can cause vascular endothelial dysfunctions that eventually disturb blood flow (1). In the early pathogenesis of atherosclerosis, the endothelium is activated by a variety of relevant stimuli, including oxidized lipids, cytokines, or signaling molecules such as endotoxins, and viruses, subsequently expressing specific adhesion receptors that enhance mononuclear cell recruitment into the vessel wall (2,3).The immune reactions in atherosclerotic lesions are mediated by nitric oxide (NO) and cyclooxygenase-2 (COX-2) (4). In the physiological function of the endothelium, NO production is required to inhibit monocyte adhesion and smooth muscle cell chemotaxis and proliferation (5). However, high levels of NO, which are produced by inducible NO synthase (iNOS) in response to stimuli, induce subsequent inflammatory reactions, thus contributing to the progression of atherosclerosis (6). COX-2 has also been associated with pro-atherogenic reactions, generating lipid mediators of inflammation, such as prostaglandin E 2 (PGE 2 ) (7).Epidemiological data continue to support the premise that dietary intake of natural products may improve vascular endothelial dysfunction in both in vivo and in vitro atherosclerotic models (8,9). For example, popular and edible mushrooms have been traditionally used to maintain health, and their components have been used in the prevention and treatment of diseases i...

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Flavonoids, Vascular Function and Cardiovascular Protection

Cited by 171 publications

References 115 publications

Effect of Lingonberry Extracts on Blood Pressure and Myocardium in Paracetamol Intoxication

Effect of Lingonberry Extracts on Blood Pressure and Myocardium in Paracetamol Intoxication

Microalgae of the Chlorophyceae Class: Potential Nutraceuticals Reducing Oxidative Stress Intensity and Cellular Damage

The n-butanol fraction of Naematoloma sublateritium suppresses the inflammatory response through downregulation of NF-κB in human endothelial cells

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