Flavonol triglycoside and investigation of the antioxidant and cell stimulating activities of Annona muricata Linn.

Abstract

Chemical investigation on leaves of Annona muricata resulted in the isolation of the flavonol triglycoside, quercetin 3-O-α-rhamnosyl-(1″″ → 6″)-β-sophoroside, together with twelve known phenolics. The structures of these compounds were established by 1D- and 2D-nuclear magnetic resonance spectroscopic techniques and mass spectrometry data. The in vitro antioxidant studies of the investigated aqueous ethanol extract and its column fractions were accomplished using the oxygen radical absorbance capacity (ORAC) method. A stimulating effect on HaCaT human keratinocytes by the leaf extract was also assessed. Il-6 production after UV irradiation was not influenced by A. muricata leaf extract.

Evaluation of mutagenic, teratogenic, and immunomodulatory effects of Annona nutans hydromethanolic fraction on pregnant mice

“…Furthermore, A. crassiflora, which also belongs to the genus Annona, did not show any mutagenic or genotoxic effects in Escherichia coli or Salmonella typhimurium tests (Vilar et al, 2008). Moreover, A. muricata presents antioxidant properties, due to the presence of the glycoside flavonoids and chlorogenic acid, which stimulate pro-mitotic growth factor in human keratinocytes (Nawwar et al, 2012).…”

Caractérisation des plantes médicinales à flavonoïdes des marchés de Douala (Cameroun)

“…Par ailleurs, les vendeurs signalent que Combretum micranthum est un puissant désinfectant et que, ses vertus favorisent l'excrétion urinaire et la sécrétion biliaire. Anonyme (2011) (Qian et Nihorimbere, 2004;Vita, 2005;Chandana Venkateswara et Vijayakuma, 2008;Eriksson, 2009;Nawwar et al, 2012). Par ailleurs, ces flavonoïdes préviennent l'oxydation des lipoprotéines de faible densité (LDL), de même que l'agrégation des plaquettes sanguines (Teissedre, 2005), évitant ainsi l'athérosclérose, un processus menant à l'apparition des maladies cardiovasculaires.…”

Phenolic Compounds from Endophytic Pseudofusicoccum sp. Isolated from Annona muricata

“…1 Ethnomedicinally, the plant has been used in the treatment of disease conditions like dysentery, fever, neuralgia, arthritis, rheumatism, cystitis, diabetes, headaches, insomnia, abscesses, tumors and cancer. 1,2,3,4 Phytochemical evaluations of the plant have shown the presence of alkaloids, 5,6 flavonol triglycosides, 7 phenolics, 8 cyclopeptides and essential oils. 9 Gas chromatography-mass spectroscopy (GC-MS) and GC analyses of the leaf oil of A. muricata showed the presence of sesquiterpenes, with β-caryophyllene being the most abundant.…”