Flaxseed Mucilage Hydrogel based Floating Drug Delivery System: Design and Evaluation

Ramteke, Shreya; Haigune, Naresh; More, Sachin; Pise, Shilpa; Pise, Ajay G.; Kharwade, Rohini

doi:10.52711/0974-360x.2022.00258

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…This mechanism showed an initial burst released during the 4 h when the concentration of the dissolved drug in the hydrogel vehicle was high. It was followed by a sustained release for the duration up to 24 h. This happened because Tz was entrapped in TFs and the fraction of the Tz particles were dispersed in the homogeneous hydrogel matrix [ 31 , 32 ]. The Korsmeyer–Peppas release exponent data showed a non-Fickian anomalous release with an n value of 0.533.…”

Section: Discussionmentioning

confidence: 99%

DOE-Assisted Formulation, Optimization, and Characterization of Tioconazole-Loaded Transferosomal Hydrogel for the Effective Treatment of Atopic Dermatitis: In Vitro and In Vivo Evaluation

Kharwade

Ali

Gangane

et al. 2023

Gels

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The present study was performed to determine the therapeutic effects of tioconazole (Tz)-loaded novel transferosome carriers (TFs) for the treatment of atopic dermatitis (AD). Method: Tioconazole transferosomes suspension (TTFs) was formulated and optimized using a 32 factorial design. After that, the optimized batch of TTFs loaded into Carbopol 934 and sodium CMC was prepared with hydrogel and noted as TTFsH. Subsequently, it was evaluated for pH, spread ability, drug content, in vitro drug release, viscosity, in vivo scratching and erythema score, skin irritation, and histopathology study. Result: The optimized batch of TTFs (B4) showed the values of vesicle size, flux, and entrapment efficiency to be 171.40 ± 9.03 nm, 48.23 ± 0.42, and 93.89 ± 2.41, respectively. All batches of TTFsH showed sustained drug release for up to 24 h. The F2 optimized batch released Tz in an amount of 94.23 ± 0.98% with a flux of 47.23 ± 0.823 and followed the Higuchi kinetic model. The in vivo studies provided evidence that the F2 batch of TTFsH was able to treat atopic dermatitis (AD) by reducing the erythema and the scratching score compared to that of the marketed formulation (Candiderm cream, Glenmark). The histopathology study supported the result of the erythema and scratching score study with intact skin structure. It showed that a formulated low dose of TTFsH was safe and biocompatible to both the dermis and the epidermis layer of skin. Conclusion: Thus, a low dose of F2-TTFsH is a promising tool that effectively targeted the skin for the topical delivery of Tz to treat atopic dermatitis symptoms.

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Section: Discussionmentioning

confidence: 99%

DOE-Assisted Formulation, Optimization, and Characterization of Tioconazole-Loaded Transferosomal Hydrogel for the Effective Treatment of Atopic Dermatitis: In Vitro and In Vivo Evaluation

Kharwade

Ali

Gangane

et al. 2023

Gels

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Modern quality control methods of flax seeds herbal drugs in Russia

D.O.,

M.N.,

M.N.

et al. 2024

RJPT

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Flax seeds are valuable medicinal and food raw materials because of their various complex of biologically active substances (BAS). They have a great potential for pharmaceutical practice and food industry. The purpose of the work is to study the possibilities for improvement of methods for standardization of flax seeds and drugs (infusion is the dietary supplement (DS), which contains fatty flax seeds extra virgin oil in gelatin capsule and fatty flax seeds oil containing in multicomponent drugs) on their basis. The following groups of BAS are studied by modern physicochemical methods: contents of polysaccharides (gravimetry), contents and composition of the fatty acids containing in fatty oils (gas flame photometric chromatography) and contents of vitamins B2, C, E, carotenoids (α- and β-carotenoids) (high-performance UV chromatography). The study establishes, that the whole flax seeds contain 8.23±0.38% of polysaccharides, 438±53 mg/g of fatty oils (the main fatty acids are α-linoleic acid (234±47 mg/g), oleic acid (60±12 mg/g), and linoleic acid (61±12 mg/g)), 31.00±4.65 mg/100g of vitamin B2, 330.00±49.50 mg/100g of vitamin C, 19.60±2.94 mg/100g of vitamin E, and 10.30±1.55 mg/100g of carotenoids. Contents of 0.62±0.04% of polysaccharides, 2.85±0.43 µg/100 ml of vitamin B2, and 45.00±6.75 µg/100 ml of vitamin C are peculiar to the infusion. We have determined that the DS “Flax seeds oil in capsules” contents three major fatty acids. They are α-linoleic acid (234±47 mg/g), oleic acid (60±12 mg/g), linoleic acid (61±1 2mg/g), 27.00±4.05 mg/100g of vitamin E (summarized tocopherols in terms of tocopherol acetate), and 14.90±2.24 mg/100g of carotenoids. Contents of fatty oil in the “Dicloran ® Plus” drug is of 277±33 mg/g (the main fatty acids are α-linoleic acid (20±4 mg/g), oleic acid (6±1 mg/g), and linoleic acid (4±1 mg/g)) and 1.10±0.17 µg/100 g of vitamin E. Ratio of major fatty acids containing in the subjects, which consist of fatty flax seeds oils, are: α-linoleic acid: oleic acid: linoleic acid is 4:1:1 is peculiar. The received data is used to update current regulatory documentation and to introduce the new one to regulate quality of flax seeds and flax drugs.

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Flaxseed Mucilage Hydrogel based Floating Drug Delivery System: Design and Evaluation

Cited by 2 publications

References 19 publications

DOE-Assisted Formulation, Optimization, and Characterization of Tioconazole-Loaded Transferosomal Hydrogel for the Effective Treatment of Atopic Dermatitis: In Vitro and In Vivo Evaluation

DOE-Assisted Formulation, Optimization, and Characterization of Tioconazole-Loaded Transferosomal Hydrogel for the Effective Treatment of Atopic Dermatitis: In Vitro and In Vivo Evaluation

Modern quality control methods of flax seeds herbal drugs in Russia

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