Flaxseed oil as a protective agent against bisphenol-A deleterious effects in male mice

Abstract

Background: Flaxseed oil is one of the most vital oils that contain a high content of omega-3 polyunsaturated fatty acids (PUFAs) recognized as a high-quality nutrition for health benefits. In addition, a source of vitamin E and β-carotene has a positive health effect in a variety of pathologies. The goal of the present work was to investigate the protecting character of flaxseed oil against bisphenol-A deleterious effects in male mice. Animals were gavaged with BPA for 28 successive days. They were orally administered flaxseed oil either before, with, or after treatment of BPA. DNA damage was evaluated in the liver, testes, and bone marrow cells using comet and micronucleus assays. Liver and testes histopathological examination as well as sperm physical characters were also investigated. Results: The results showed that BPA induced a significant raise in DNA damage that obviously appear in the increase of tail length, tail DNA percentage, and tail moment in the liver and testes. In addition, there was an increase in the frequency of micronuclei in bone marrow cells. Liver and testes histopathological alterations and sperm count and motility significant comedown were seen in male mice exposed to BPA as well. Conversely, flaxseed oil oral administration through the three regimens of treatment effectively attenuated the abovementioned effects. Moreover, administration of flaxseed oil before BPA treatment was the best protocol in the attenuation of BPA toxic effects. Conclusions: Flaxseed oil successfully attenuated the BPA genotoxicity, sperm defects, and histological alterations in male mice that may be referred to its antioxidant property.

Effect of Flax Seed Oil on Acute Carbon Tetrachloride-induced Hepatic Injury and Determination of Hepatic Apoptosis in Rats

“…Researchers using flaxseed extract [30,31,32], against CCl 4induced the liver toxicity reported that flaxseed extract had ameliorative effects on liver necrosis, fat vacuoles and inflammatory cell infiltration. There are some studies using FSO to improve liver damage created by different toxic substances [33,34,35,36,37,38]. In these studies, it was reported that FSO administration increased the numbers of Kupffer cells and decreased cytoplasmic lipid vacuole formation, degeneration and necrosis in hepatocytes as well as inflammatory cell infiltrations.…”

Fluorescence Spectroscopy Based Characterization of Flaxseed Oil

“…Therefore, the additional use of axseed oil may be bene cial in regulating the desired ratio of fatty acids. It also contains isomers of vitamin E and carotenoids that proved a positive health effect in a variety of pathologies [12] and showed antioxidant effects [7,13]. It showed other health bene ts such as anti-tumor, anti-in ammatory and liver protection [14].…”