Flaxseed Oil Supplementation Does Not Affect Plasma Lipoprotein Concentration or Particle Size in Human Subjects

Harper, Charles R.; Edwards, M. C.; Jacobson, Terry A.

doi:10.1093/jn/136.11.2844

Cited by 77 publications

(49 citation statements)

References 27 publications

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“…Most studies have reported (Singer et al, 1986;Cunnane et al, 1995;Nestel et al, 1997;Rallidis et al, 2003;Harper et al, 2006b) little or no effect of flaxseed on blood total cholesterol, low-density lipoprotein or high-density lipoprotein. Studies investigating the effect of ALA on fasting TGs are contradictory with an increase (Cunnane et al, 1995), decrease (Singer et al, 1986;Djoussé et al, 2003;Zhao et al, 2004) or no effects (Nestel et al, 1997;Rallidis et al, 2003) reported.…”

Section: Discussionmentioning

confidence: 99%

Bioavailability of α-linolenic acid from flaxseed diets as a function of the age of the subject

et al. 2009

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Background: Dietary flaxseed may have beneficial cardiovascular effects. An aged population has a higher incidence of cardiovascular disease, but they may react differently to flaxseed in the diet. Objective: To investigate the response, over a period of 4 weeks, of subjects aged 18-29 or 45-69 years to a diet containing the same amount of a-linolenic acid (ALA) (6 g) introduced in the form of ground flaxseed (30 g) or flaxseed oil. Results: All subjects who received flaxseed oil showed a significant increase in plasma ALA and eicosapentaenoic acid (EPA) concentrations over the course of this study. Subjects who received ground flaxseed in the 18-29-year-old group showed a statistically significant increase in their plasma ALA levels, and although there was a trend in the same direction for the 45-69-year-old subjects, this did not achieve statistical significance. The diets induced no major changes in platelet aggregation, plasma total cholesterol, low-density lipoprotein or high-density lipoprotein cholesterol levels in any of the groups. Younger subjects showed a decrease in triglyceride (TG) values compared with older subjects. There were no significant side effects that caused compliancy issues. Conclusion: Subject age does not seem to be a major determining factor in influencing ALA absorption from a flaxseedsupplemented diet nor in the metabolism of ALA to EPA in the groups fed flaxseed oil. Concerns about side effects in older subjects administered a higher fiber load in a flaxseed-supplemented diet are not justified. However, younger but not older subjects showed a beneficial decrease in circulating TGs due to flaxseed supplementation.

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Section: Discussionmentioning

confidence: 99%

Bioavailability of α-linolenic acid from flaxseed diets as a function of the age of the subject

et al. 2009

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“…Inflammation plays an important role in T2DM, obesity and CVD, and so reductions in inflammatory markers such as CRP may be useful as measures of overall health risk (280). However, prospective studies evaluating the effects of dietary supplementation with marine and plant-based n-3s have not demonstrated significant changes in CRP levels (281)(282)(283).…”

Section: Effects On Cardiovascular Disease Risk Factorsmentioning

confidence: 99%

The Effect of Salvia Hispanica L. Seeds on Weight Loss in Overweight and Obese Individuals with Type 2 Diabetes Mellitus

Brissette¹,

Jenkins²,

Choleva³

et al. 2013

Canadian Journal of Diabetes

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There is growing interest in the potential role of omega-3/fibre-rich seeds in attenuating obesity and other cardiovascular disease (CVD) risk factors in individuals with type 2 diabetes mellitus (T2DM).Preliminary data suggests that consumption of white Salvia hispanica L. (Salba ® ) seeds prolongs satiety and may aid weight loss. This randomized, double-blind, parallel study assessed the efficacy and safety of Salvia hispanica in overweight/obese individuals with T2DM on weight, body composition, glycemic control and other CVD risk factors. Fifty-eight participants consumed a hypocaloric diet including Salvia hispanica or an energy-and-fibre-matched control over 24 weeks. Greater reductions in weight, waist circumference and inflammation occurred in the Salvia hispanica group versus control. There were no significant between-group differences in safety parameters, glycemic control or other CVD risk factors.Salvia hispanica seeds may support weight loss in overweight/obese individuals with T2DM. Further research is needed to determine whether these effects are maintained.iii

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“…However other seed oils (i.e. sunflower, soybean, and rapeseed), which also contain high concentrations of oleic acid, do not exhibit the same health benefits as EVOO (López-Miranda et al, 2010, Harper et al, 2006, Aguilera et al, 2004. In addition to oleic acid, EVOO contains a minor, yet significant phenolic fraction that other seed oils lack and this fraction has generated much interest regarding its health promoting properties.…”

Section: Olive Oil Phenolic Compoundsmentioning

confidence: 99%

Oleocanthal: A Naturally Occurring Anti-Inflammatory Agent in Virgin Olive Oil

Cicerale¹,

Lucas²,

Keast³

2012

Olive Oil - Constituents, Quality, Health Properties and Bioconversions

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Flaxseed Oil Supplementation Does Not Affect Plasma Lipoprotein Concentration or Particle Size in Human Subjects

Cited by 77 publications

References 27 publications

Bioavailability of α-linolenic acid from flaxseed diets as a function of the age of the subject

Bioavailability of α-linolenic acid from flaxseed diets as a function of the age of the subject

The Effect of Salvia Hispanica L. Seeds on Weight Loss in Overweight and Obese Individuals with Type 2 Diabetes Mellitus

Oleocanthal: A Naturally Occurring Anti-Inflammatory Agent in Virgin Olive Oil

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