Flecainide in clinical practice

Basza, Mikołaj; Maciejewski, Cezary; Bojanowicz, Wojciech; Balsam, Paweł; Grabowski, Marcin; Mitkowski, Przemysław; Kempa, Maciej; Kowalski, Oskar; Kalarus, Zbigniew; Jaguszewski, Miłosz; Lubiński, Andrzej; Daniłowicz‐Szymanowicz, Ludmiła; Szumowski, Łukasz; Sterliński, Maciej; Kołtowski, Łukasz

doi:10.5603/cj.a2023.0018

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…He also received a radioisotope stress test to rule out any coronary artery disease. The stress test was negative for any coronary artery disease and therefore, Flecainide therapy was subsequently initiated [13].…”

Section: Discussionmentioning

confidence: 99%

“…During the next two years, the focus of treatment was the symptomatic arrhythmia. He was started on Flecainide [13] following a negative stress test to rule out coronary artery disease. At the age of 57.7 years, he received a cavotricuspid isthmus ablation.…”

Section: Case Presentationmentioning

confidence: 99%

“…discontinued and only Eliquis anticoagulation therapy was continued [12][13]. Episodes of lone atrial flutter and atrial fibrillation, which had been occurring on a weekly basis, were now nonexistent with the exception of one episode documented over the next four years.…”

Section: Clinicsearchmentioning

confidence: 99%

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Systematic Increases in the Aortic Ejection Velocity with Decreasing Deuterium Content in Food

C. Jones

2024

CRC

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The deuterium concentration in the fattyacids of food consumed was recently shownto impact the maximal rate of ATP production effecting the resting heart rates in six volunteers. One of these volunteers had three echocardiocardiograms to evaluate an intermittent systolic ejection murmur that first appeared after adopting a ketogenic diet and this murmur became more pronounced following a low deuterium cold water sea food diet. The echocardiograms revealed that the aortic ejectionvelocity and aortic pressuregradients systematically increasewith decreasing deuteriumlevels in the diet. These findings reveal that the meals consumed do have a significant impact on the parameters determined from echocardiography likely due to changes in the ventricular contractility. The aorticpressure gradients extrapolate to zero as the deuterium content approaches 155.9 ppm.

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Section: Discussionmentioning

confidence: 99%

Section: Case Presentationmentioning

confidence: 99%

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Systematic Increases in the Aortic Ejection Velocity with Decreasing Deuterium Content in Food

C. Jones

2024

CRC

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The network of cardiac KIR2.1: its function, cellular regulation, electrical signaling, diseases and new drug avenues

Li,

van der Heyden

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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The functioning of the human heart relies on complex electrical and communication systems that coordinate cardiac contractions and sustain rhythmicity. One of the key players contributing to this intricate system is the KIR2.1 potassium ion channel, which is encoded by the KCNJ2 gene. KIR2.1 channels exhibit abundant expression in both ventricular myocytes and Purkinje fibers, exerting an important role in maintaining the balance of intracellular potassium ion levels within the heart. And by stabilizing the resting membrane potential and contributing to action potential repolarization, these channels have an important role in cardiac excitability also. Either gain- or loss-of-function mutations, but also acquired impairments of their function, are implicated in the pathogenesis of diverse types of cardiac arrhythmias. In this review, we aim to elucidate the system functions of KIR2.1 channels related to cellular electrical signaling, communication, and their contributions to cardiovascular disease. Based on this knowledge, we will discuss existing and new pharmacological avenues to modulate their function.

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New focus on cardiac voltage-gated sodium channel β1 and β1B: Novel targets for treating and understanding arrhythmias?

Williams,

Payne,

et al. 2025

Heart Rhythm

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Flecainide in clinical practice

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Cardiology Journal" are listed in PubMed.

Cited by 4 publications

References 36 publications

Systematic Increases in the Aortic Ejection Velocity with Decreasing Deuterium Content in Food

Systematic Increases in the Aortic Ejection Velocity with Decreasing Deuterium Content in Food

The network of cardiac KIR2.1: its function, cellular regulation, electrical signaling, diseases and new drug avenues

New focus on cardiac voltage-gated sodium channel β1 and β1B: Novel targets for treating and understanding arrhythmias?

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