Fleckfieberstudien. I. Mitteilung: Nachweis eines Toxins in Rickettsien-Eikulturen (Rickettsia mooseri)

Lysosomes and the "toxicity" of Rickettsiales. I. Cytochemical studies of macrophages inoculated in vitro with C. psittaci 6BC

“…Cells stained with M G G (Figs. [16][17][18][19] plasmic granules" which represent lysosomes observed in the late stages of productive in- (12). fection of C. psittaci (36).…”

“…(TE) that is not connected with the replication Several species of Chlanlydia have been shown to produce a toxic effect on intact animals, as well as on specific tissues and cells; this effect is analogous to that produced by several species of Rickettsiae (26,33), and the factor producing the effect has been called a "toxin" (16). Many serious attempts over the years to identify a toxin have failed and the mechanism of this injurious effect remains to be established.…”

The Significance and Applications of Bacteriophage in Bacteriological and Virus Research 1

“…In 1940, Gildemeister and Haagen (38) discovered what is usually described as a toxic substance in the yolk sac of eggs infected with murine typhus rickettsiae. The specific lethal effect produced in a few hours, when very high concentrations of murine or epidemic typhus rickettsiae are injected intravenously in the mouse, has been employed extensively in typhus studies during the past war.…”

Some Aspects of Variation in Rickettsial Virulence

“…There is good evidence, however, that these two interactions reproduce at least one important step that leads to infection, possibly cell penetration. Mouse toxin (Gildemeister and Haagen, 1940) and rabbit or sheep cell hemolysin (Clark and Fox, 1948) are intimately associated with the viability of the rickettsiae. Of the many attempts to separate the various properties of typhus rickettsiae, only moderate irradiation with ultraviolet light has been successful in selectively destroying infectivity (Allen el a,!., 1954).…”