Flexible and biodegradable electronic implants for diagnosis and treatment of brain diseases

Lee, Wang Hee; Doo, Gi; Kim, Dae‐Hyeong

doi:10.1016/j.copbio.2021.07.027

Cited by 29 publications

(18 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Insulators such as nitrides, oxides, and polymers can serve as dielectrics, substrates, or encapsulations for implantable devices. 203 The dissolution rates of these insulating materials are typically low and are influenced by many factors such as porosity and density.…”

Section: Fe 3omentioning

confidence: 99%

Recent Development of Implantable Chemical Sensors Utilizing Flexible and Biodegradable Materials for Biomedical Applications

Hu,

Wang,

Liu

et al. 2024

ACS Nano

View full text Add to dashboard Cite

Implantable chemical sensors built with flexible and biodegradable materials exhibit immense potential for seamless integration with biological systems by matching the mechanical properties of soft tissues and eliminating device retraction procedures. Compared with conventional hospital-based blood tests, implantable chemical sensors have the capability to achieve real-time monitoring with high accuracy of important biomarkers such as metabolites, neurotransmitters, and proteins, offering valuable insights for clinical applications. These innovative sensors could provide essential information for preventive diagnosis and effective intervention. To date, despite extensive research on flexible and bioresorbable materials for implantable electronics, the development of chemical sensors has faced several challenges related to materials and device design, resulting in only a limited number of successful accomplishments. This review highlights recent advancements in implantable chemical sensors based on flexible and biodegradable materials, encompassing their sensing strategies, materials strategies, and geometric configurations. The following discussions focus on demonstrated detection of various objects including ions, small molecules, and a few examples of macromolecules using flexible and/or bioresorbable implantable chemical sensors. Finally, we will present current challenges and explore potential future directions.

show abstract

Section: Fe 3omentioning

confidence: 99%

Recent Development of Implantable Chemical Sensors Utilizing Flexible and Biodegradable Materials for Biomedical Applications

Hu,

Wang,

Liu

et al. 2024

ACS Nano

View full text Add to dashboard Cite

show abstract

“…Encapsulation of pharmacological agents on flexible substrates (or with integrated flexible electronics) also enables controlled drug delivery in the brain. 122,123 Lee et al developed a drug-loaded flexible and biodegradable patch for intracranial drug delivery with wireless control (Fig. 7b).…”

Section: Other Minimally Invasive Implants For Drug Delivery With Act...mentioning

confidence: 99%

Miniaturized neural implants for localized and controllable drug delivery in the brain

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The importance of developing sustainable and degradable materials cannot be understated, in regard to realizing sustainable electronics ecosystem. Alternative to the traditional "long-lasting" electronics paradigm, transient or biodegradable electronics are being developed to reduce e-waste 3 and for biologically and environmentally interfacing applications [4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Elastomeric Circuit Boards from Citric Acid-based Polyesters

Daniele

Turner

Twiddy

et al. 2022

Preprint

View full text Add to dashboard Cite

Recyclable and biodegradable microelectronics, i.e., “green” electronics, are emerging as a viable solution to the global challenge of electronic waste. Accordingly, the development of novel materials to replace passive components and packaging is necessary to realize sustainable manufacturing and growing distribution of electronic devices. Specifically, alternatives to printed circuit boards (PCBs) represent a prime target for novel materials development and increasing the utility of green electronics in biomedical and Internet-of-Things (IoT) applications. Ideal PCB substrates and packaging are good dielectrics, mechanically and thermally robust, and are compatible with traditional microfabrication processes, which typically result in the use of non-biodegradable materials. Poly(octamethylene maleate (anhydride) citrate) (POMaC) – a citric acid-based elastomer with tunable degradation and mechanical properties – presents a promising alternative for PCB substrates and packaging. Here, we report the novel use and characterization of POMaC-PCBs. Synthesis and processing conditions were optimized to achieve desired degradation and mechanical properties for production of stretchable circuits. POMAC-PCB traces were characterized and exhibited sheet resistance of 0.599 Ω cm-2, crosstalk distance of <0.6 mm, and R/R0 = 30 after 100 cycles to 20% strain. Fabrication of single and multilayer layer POMaC-PCBs was demonstrated.

show abstract

Flexible and biodegradable electronic implants for diagnosis and treatment of brain diseases

Cited by 29 publications

References 64 publications

Recent Development of Implantable Chemical Sensors Utilizing Flexible and Biodegradable Materials for Biomedical Applications

Recent Development of Implantable Chemical Sensors Utilizing Flexible and Biodegradable Materials for Biomedical Applications

Miniaturized neural implants for localized and controllable drug delivery in the brain

Biodegradable Elastomeric Circuit Boards from Citric Acid-based Polyesters

Contact Info

Product

Resources

About