Flexible and hierarchical metal-organic framework composite as solid-phase media for facile affinity-tip fabrication to selectively enrich glycopeptides and phosphopeptides

Ali, Muhammad Mujahid; Zhu, Zhiyuan; Hussain, Dilshad; Shen, Zhengchao; He, Yizhu; Du, Zhenxia

doi:10.1016/j.talanta.2021.122576

Cited by 28 publications

(7 citation statements)

References 61 publications

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“…The detection limits acquired in this work are lower than or equal to those in recently reported literature (Table S2, ESI †). [47][48][49][50] High selectivity is the key to ensure that an adsorbent can specifically capture phosphopeptides/glycopeptides from complicated samples. 51 To investigate the selectivity of phosphopeptide enrichment, b-casein digests mixed with 500-fold or 5000-fold bovine serum albumin (BSA) digests were selected as testing samples.…”

Section: Resultsmentioning

confidence: 99%

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Tailoring a multifunctional magnetic cationic metal–organic framework composite for synchronous enrichment of phosphopeptides/glycopeptides

et al. 2022

J. Mater. Chem. B

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Section: Resultsmentioning

confidence: 99%

“…The detection limits acquired in this work are lower than or equal to those in recently reported literature (Table S2, ESI†). 47–50…”

Section: Resultsmentioning

confidence: 99%

Tailoring a multifunctional magnetic cationic metal–organic framework composite for synchronous enrichment of phosphopeptides/glycopeptides

et al. 2022

J. Mater. Chem. B

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“…In addition, compared with other MOF materials, Fe 3 O 4 -POMOFs exhibited better enrichment performance for phosphopeptides (Table ). − …”

Section: Resultsmentioning

confidence: 99%

Effective Enrichment of Phosphopeptides Using Magnetic Polyoxometalate-Based Metal–Organic Frameworks

Jiang,

Wu,

et al. 2023

ACS Biomater. Sci. Eng.

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“…Additionally, branched polymers can be coupled with other materials to increase the interactions with the targeted analytes [84,92]. Ali et al [93] synthetized a flexible material denominated MF@PDA@UiO-66-NH 2 -tip that was employed to selectively enrich glycopeptides and phosphopeptides. The material's flexibility brought better mechanical strength with fewer blocking problems.…”

Section: Enrichment Using Hydrophilic Materialsmentioning

confidence: 99%

Advances in mass spectrometry‐based glycoproteomics: An update covering the period 2017–2021

et al. 2021

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Protein glycosylation is one of the most common posttranslational modifications, and plays an essential role in a wide range of biological processes such as immune response, intercellular signaling, inflammation, host-pathogen interaction, and protein stability. Glycoproteomics is a proteomics subfield dedicated to identifying and characterizing the glycans and glycoproteins in a given cell or tissue. Aberrant glycosylation has been associated with various diseases such as Alzheimer's disease, viral infections, inflammation, immune deficiencies, congenital disorders, and cancers. However, glycoproteomic analysis remains challenging because of the low abundance, site-specific heterogeneity, and poor ionization efficiency of glycopeptides during LC-MS analyses. Therefore, the development of sensitive and accurate approaches to efficiently characterize protein glycosylation is crucial. Methods such as metabolic labeling, enrichment, and derivatization of glycopeptides, coupled with different mass spectrometry techniques and bioinformatics tools, have been developed to achieve sophisticated levels of quantitative and qualitative analyses of glycoproteins. This review attempts to update the recent developments in the field of glycoproteomics reported between 2017 and 2021.

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Flexible and hierarchical metal-organic framework composite as solid-phase media for facile affinity-tip fabrication to selectively enrich glycopeptides and phosphopeptides

Cited by 28 publications

References 61 publications

Tailoring a multifunctional magnetic cationic metal–organic framework composite for synchronous enrichment of phosphopeptides/glycopeptides

Tailoring a multifunctional magnetic cationic metal–organic framework composite for synchronous enrichment of phosphopeptides/glycopeptides

Effective Enrichment of Phosphopeptides Using Magnetic Polyoxometalate-Based Metal–Organic Frameworks

Advances in mass spectrometry‐based glycoproteomics: An update covering the period 2017–2021

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