Flexible and stretchable opto-electric neural interface for low-noise electrocorticogram recordings and neuromodulation in vivo

Ji, Bowen; Ge, Chaofan; Guo, Zhejun; Wang, Longchun; Wang, Minghao; Xie, Zhaoqian; Xu, Yeshou; Li, Haibo; Yang, Bin; Wang, Xiaolin; Li, Chengyu; Liu, Jingquan

doi:10.1016/j.bios.2020.112009

Cited by 55 publications

(45 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the increase of the integration degree of the optrodes, the illumination can induce optical artifacts to interfere with the microelectrode/electrolyte interface and contaminate the recorded neural signals [ 26 , 27 , 28 , 29 , 30 , 31 ]. In order to get a higher signal-to-noise ratio for the measured neural signal, eliminating optical artifacts becomes an important function for optrodes [ 29 , 33 , 49 ], so it is necessary to investigate the influence of light upon the charge transfer on the interface.…”

Section: Resultsmentioning

confidence: 99%

“…Other than that, it has been reported that the optical artifacts can be found on the microelectrodes, when illumination is introduced to the microelectrode/ electrolyte interface. Optical artifacts are the inevitable problem of all types of optrodes, and the explanations for this artifact have yet to reach an agreement [ 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of the Surface Material and Illumination upon the Performance of a Microelectrode/Electrolyte Interface in Optogenetics

Shen

Xiao

et al. 2021

Micromachines

View full text Add to dashboard Cite

Integrated optrodes for optogenetics have been becoming a significant tool in neuroscience through the combination of offering accurate stimulation to target cells and recording biological signals simultaneously. This makes it not just be widely used in neuroscience researches, but also have a great potential to be employed in future treatments in clinical neurological diseases. To optimize the integrated optrodes, this paper aimed to investigate the influence of surface material and illumination upon the performance of the microelectrode/electrolyte interface and build a corresponding evaluation system. In this work, an integrated planar optrode with a blue LED and microelectrodes was designed and fabricated. The charge transfer mechanism on the interface was theoretically modeled and experimentally verified. An evaluation system for assessing microelectrodes was also built up. Using this system, the proposed model of various biocompatible surface materials on microelectrodes was further investigated under different illumination conditions. The influence of illumination on the microelectrode/electrolyte interface was the cause of optical artifacts, which interfere the biological signal recording. It was found that surface materials had a great effect on the charge transfer capacity, electrical stability and recoverability, photostability, and especially optical artifacts. The metal with better charge transfer capacity and electrical stability is highly possible to have a better performance on the optical artifacts, regardless of its electrical recoverability and photostability under the illumination conditions of optogenetics. Among the five metals used in our investigation, iridium served as the best surface material for the proposed integrated optrodes . Thus, optimizing the surface material for optrodes could reduce optical interference, enhance the quality of the neural signal recording for optogenetics, and thus help to advance the research in neuroscience.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of the Surface Material and Illumination upon the Performance of a Microelectrode/Electrolyte Interface in Optogenetics

Shen

Xiao

et al. 2021

Micromachines

View full text Add to dashboard Cite

show abstract

“…For mechanical signal monitoring, flexible strain sensors, [ 6,7 ] pressure sensors, [ 8,9 ] and sound sensors [ 10,11 ] can be used to measure vital signs such as pulse, heart rate, body temperature, and voice. [ 12,13 ] For electrical signal monitoring, flexible electrodes [ 14 ] can measure the electrocardiogram, [ 15,16 ] electroencephalogram, [ 17–19 ] electromyogram, [ 20 ] electrooculogram, [ 21 ] and electroneurogram. [ 22 ] For biochemical signal monitoring, flexible biosensors [ 23 ] can measure glucose, [ 24–26 ] ethanol, [ 27 ] lactate, [ 28 ] and other ions [ 29 ] in body fluids.…”

Section: Introductionmentioning

confidence: 99%

Interfacial Liquid Film Transfer Printing of Versatile Flexible Electronic Devices with High Yield Ratio

Chen

Liu

et al. 2021

Adv Materials Inter

View full text Add to dashboard Cite

Emerging flexible electronic devices differ widely in terms of material, shape, scale, and structure. The conventional solid‐contact stamp transfer printing method easily causes cracks and interfacial delamination in large‐area, intricately‐patterned multilayered devices. Liquid film transfer printing (LTP) is presented as a strategy to obtain flexible devices with a high yield ratio regardless of the device material, scale, shape, and structure. In this technique, the liquid film is used to hydrolyze and break the chemical bonds between the film and silicon wafer substrate. Thus, there is less stress on the device during the transfer process. In addition, the buoyancy and surface tension of the liquid film help the flexible device to unroll itself on the liquid surface. In the experiments, flexible devices of different types and with extreme properties consistently achieved a transfer printing yield ratio of 98.57%. The sensitivity of temperature sensor change before and after LTP is less than 2%. The real‐time and visualized comparisons of the stress distribution and evolution during LTP and solid‐contact methods demonstrated that the LTP maximum strain is 70% smaller than the latter method. Thus, LTP has great potential for sophisticated and system‐level flexible device transfer printing and integration.

show abstract

“…Brain-computer interface (BCI) technology shows great value in the clinical treatment of brain diseases-including stroke and epilepsy-and plays a vital role in frontier scientific fields such as brain research, bioelectronics, and nerve prosthetics [1][2][3][4][5][6]. Implantable BCI, as a common tool to record neural signals in biomedical research, can be divided into cortical electrodes and intracranial penetrating electrodes, according to the different implantation sites [7][8][9][10][11][12][13][14][15][16]. Meanwhile, the implantable BCI has expanded many functional features, including the modulation of neural activities by light, electrical and magnetic stimulation, and drug delivery via microfluidics to achieve local control or treatment [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Implantable Thin Film Devices as Brain-Computer Interfaces: Recent Advances in Design and Fabrication Approaches

Zhou

Wang

et al. 2021

Coatings

Self Cite

View full text Add to dashboard Cite

Remarkable progress has been made in the high resolution, biocompatibility, durability and stretchability for the implantable brain-computer interface (BCI) in the last decades. Due to the inevitable damage of brain tissue caused by traditional rigid devices, the thin film devices are developing rapidly and attracting considerable attention, with continuous progress in flexible materials and non-silicon micro/nano fabrication methods. Therefore, it is necessary to systematically summarize the recent development of implantable thin film devices for acquiring brain information. This brief review subdivides the flexible thin film devices into the following four categories: planar, open-mesh, probe, and micro-wire layouts. In addition, an overview of the fabrication approaches is also presented. Traditional lithography and state-of-the-art processing methods are discussed for the key issue of high-resolution. Special substrates and interconnects are also highlighted with varied materials and fabrication routines. In conclusion, a discussion of the remaining obstacles and directions for future research is provided.

show abstract

Flexible and stretchable opto-electric neural interface for low-noise electrocorticogram recordings and neuromodulation in vivo

Cited by 55 publications

References 33 publications

Influence of the Surface Material and Illumination upon the Performance of a Microelectrode/Electrolyte Interface in Optogenetics

Influence of the Surface Material and Illumination upon the Performance of a Microelectrode/Electrolyte Interface in Optogenetics

Interfacial Liquid Film Transfer Printing of Versatile Flexible Electronic Devices with High Yield Ratio

Implantable Thin Film Devices as Brain-Computer Interfaces: Recent Advances in Design and Fabrication Approaches

Contact Info

Product

Resources

About