2015
DOI: 10.1049/el.2015.2371
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Flexible low‐cost cardiovascular risk marker biosensor for point‐of‐care applications

Abstract: The detection and quantification of protein on a laser written flexible substrate for point-of-care applications are described. A unique way of etching gold on polyethylene terephthalate (PET) substrate is demonstrated by reducing the damage that may be caused on PET sheets otherwise. On the basis of the quantity of the C-reactive protein (CRP) present in the sample, the risk of cardiac disease can be assessed. This hsCRP test is incorporated to detect the presence of CRP on a PET laser patterned biosensor. Co… Show more

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Cited by 28 publications
(15 citation statements)
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“…Many fabricating techniques have been adopted in recent years, which include time-consuming techniques such as photolithography, 27 etching, 28 and the computer numerical control (CNC) micro-milling method 29 . Laser-directed writing is a good tool choice for micromachining, as it provides a simple and inexpensive method of operation 30 . Ultrafast femtosecond laser processing, 31 as well as IR lasers and UV lasers, have been used to fabricate devices based on their applications 32–34 .…”
Section: Introductionmentioning
confidence: 99%
“…Many fabricating techniques have been adopted in recent years, which include time-consuming techniques such as photolithography, 27 etching, 28 and the computer numerical control (CNC) micro-milling method 29 . Laser-directed writing is a good tool choice for micromachining, as it provides a simple and inexpensive method of operation 30 . Ultrafast femtosecond laser processing, 31 as well as IR lasers and UV lasers, have been used to fabricate devices based on their applications 32–34 .…”
Section: Introductionmentioning
confidence: 99%
“…Though traditional laboratory equipment has been used for the above-mentioned assays, microfluidic devices to a greater extent have numerous merits over the macrosystems because it reduces sample volume, reduces reagent cost, is disposable and streamlines complex assay protocols [12]. These merits account for the development of laboratory-based POC diagnostic microfluidics systems and high-throughput analytical devices to be foreseen [13]. These minuscule devices' dimensions vary between millimetres and micrometres and perform task ranging from detecting airborne toxins to analysing spheroids/ three-dimensional (3D) tissues, thus emphasising the requirement of biocompatible materials to investigate the studies.…”
Section: Introductionmentioning
confidence: 99%
“…The capacitive biosensor can be reused with extensive cleaning and recalibration of the sensors. However, they get attached to the readout circuit via a simple connector and can be made disposable due to the reduced cost of manufacturing them [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ], while the electronic readout system can be reused over and over. Moreover, the biosensors are designed to give quick readouts of the sample.…”
Section: Materials and Capacitive Sensing Elementmentioning
confidence: 99%
“…Therefore, they are very attractive for use in battery-powered systems. Capacitive biosensors for protein detection are proposed in [ 22 , 23 ], where an LCR meter has been used for capacitance measurements. The LCR meter is a bulky, complicated, and expensive instrument.…”
Section: Introductionmentioning
confidence: 99%