Wall shear stress is one of the important measurement parameters in wind tunnel experiments. In the shock wind tunnel, the duration of the flow field is very short, usually a few milliseconds. To ensure measurement accuracy, the sampling rate should not be less than 1kHz. Due to the limitation of model volume and experimental environment, it is necessary to design a miniaturized readout circuit with high precision and high sampling rate, which is highly integrated with the MEMS wall shear stress sensor. The circuit includes a micro capacitance detection module integrated with the sensor head and a host computer signal processing and display module. Aiming at the complex measurement environment of the shock tunnel, to ensure the measurement accuracy, stability, and anti-interference ability of the weak capacitance detection circuit, a miniaturized ceramic substrate circuit is fabricated by a microstrip circuit process. The test results show that the resolution of the micro capacitance of the circuit can reach 20fF at the detection frequency of 3kHz, which can meet the measurement requirements of Shock tunnel, and realize the real-time measurement and display of wall shear stress signal.