Flexible organic thin-film transistor immunosensor printed on a one-micron-thick film

Abstract

Flexible and printed biosensor devices can be used in wearable and disposable sensing systems for the daily management of health conditions. Organic thin-film transistors (OTFTs) are promising candidates for constructing such systems. Moreover, the integration of organic electronic materials and biosensors is of extreme interest owing to their mechanical and chemical features. To this end, the molecular recognition chemistry-based design for the interface between sensor devices and analyte solution is crucial to obtain accurate and reproducible sensing signals of targets, though little consideration has been given to this standpoint in the field of device engineering. Here, we report a printed OTFT on a 1 μm-thick film functionalized with a sensing material. Importantly, the fabricated device quantitatively responds to the addition of a protein immunological marker. These results provide guidelines for the development of effective healthcare tools.

A review of surface roughness impact on dielectric film properties

“…[87] Minamiki et al recently published their work about flexible TFTs as wearable immunology sensors when printed on a piece of 1 μm thin film [88]…”

Simulating the I‐V characteristics of an ultrathin IGZO‐based thin film transistor using finite element method

“…Thin film transistors (TFTs) are a special type of field-effect transistors that showed a booming trend in various applications, including but not limited to, liquid crystal display (LCD) technology, [1][2][3] gas-sensing, 4,5 biosensors 6 and wearable flexible devices. 7 Relatively low fabrication temperature and simple structures promote TFTs in transistors industry. [8][9][10] The TFT active layer is produced by depositing a thin film on a dielectric substrate.…”

Oxytocin detection at ppt level in human saliva by an extended-gate-type organic field-effect transistor

“…As a sensing platform for oxytocin detection, we have focused on an organic field-effect transistor (OFET). 14 By employing appropriate organic semiconductors, the OFET devices can be easily fabricated utilizing high-throughput printable methods (e.g., robotic dispensers and inkjet printers [15][16][17] ). Furthermore, the OFETs enable molecular recognition combined with detection portions (e.g., enzymes, [18][19][20][21] antibodies, 18,22 molecularly imprinted polymers, [23][24][25] and artificial receptors 26,27 ), allowing electrical detection in aqueous media.…”

“…Thus, modifying the detection portion on the gate electrode can endow the OFET devices with molecular detectability. [28][29][30] Indeed, we firstly detected various chemical species including anions, 21,31 amino acids, 23 and proteins 15,32 in aqueous media using the extended-gate-type OFETs. However, the realization of OFET-based hormone sensors is still in its infancy.…”

“…9 Notably, we have succeeded in the functionalization of the antibody- attached self-assembled monolayer (SAM) on the extendedgate electrodes for chemical sensing. 15,32 A short alkyl chainbased SAM could contribute to the highly sensitive detection based on chemical sensing within Debye length. 33 In this regard, amide bonds of the SAM could form intermolecular hydrogen bonds, which allow uniform membrane even with short alkyl chains.…”