Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing

Wang, Canran; Jiang, Xing; Kim, Hanjun; Zhang, Shiming; Zhou, Xingwu; Chen, Yi; Ling, Haonan; Xue, Yumeng; Chen, Zhaowei; Qu, Moyuan; Ren, Li; Zhu, Jixiang; Libanori, Alberto; Zhu, Yangzhi; Kang, Heemin; Ahadian, Samad; Dokmeci, Mehmet R.; Servati, Peyman; He, Ximin; Gu, Zhen; Sun, Wujin; Khademhosseini, Ali

doi:10.1016/j.biomaterials.2022.121479

Cited by 124 publications

(75 citation statements)

References 81 publications

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“…Optimization of magnetic field profiles such as amplitude, frequency, and pulse shapes for specific magnetotransduction with multifunctional MNPs is also important for the cue processing of in vivo magnetocellular regulation in biomedical applications. [221][222][223][224] At the same time, the magnetocell regulation area is still in its initial stage. Additional findings of biological receptors that are responsive to the magnetonanotransducers should be performed.…”

Section: Outlook and Challengesmentioning

confidence: 99%

Multifunctional Magnetic Nanoparticles for Dynamic Imaging and Therapy

Hong

Choi

et al. 2022

Advanced NanoBiomed Research

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Dynamic therapy is a key research area for noninvasive clinical therapeutics. Up to now, light, electricity, ultrasound, and magnetic field have been investigated for the potential remote cellular regulation tools. Opening ion channels, activating cell death, and manipulating individual receptors that can control various cellular signal pathways have been suggested using external energy forms that can be dynamically applied in situ, which advance from the static control strategies. [1][2][3][4] For instance, optogenetics using light [5,6] have greatly advanced cellular modulation over the past decades, especially for neuromodulation. [7] Other energy sources have also been demonstrated with promising potential for regulating cellular metabolism and death. However, controlling the penetration and localization of energy sources (e.g., light and electricity) in tissues and cells have been challenging for in vivo applications. On the other hand, a magnetic field can safely penetrate deep tissues, which is particularly relevant for clinical applications. Consequently, utilizing the magnetic field to manipulate the MNPs is emerging as an effective approach to dynamically regulate cellular activity. [8] Recent advancements of multifunctional MNPs, spintronics, and magnetogenetics have enabled precise modulation of magnetic field gradients and pulses to remotely control the movement, heat generation, and reactive oxygen species (ROS) generation of the MNPs (Figure 1).Engineering multifunctional magnetic particles is the key requirement to achieve desired biomedical applications. [9][10][11] In the past 20 years, MNPs have received increasing attention

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Section: Outlook and Challengesmentioning

confidence: 99%

Multifunctional Magnetic Nanoparticles for Dynamic Imaging and Therapy

Hong

Choi

et al. 2022

Advanced NanoBiomed Research

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“…Wang et al. [52] synthesised a conductive hydrogel (ePatch) using silver nanowires and methacrylated alginate as the electrode materials for wound healing. When the ePtach was directly applied to the wound sites and then connected to a pulse width modulation generator, it could significantly promote wound healing and reduce the expression of inflammatory factors under electric field stimulation.…”

Section: Stimuli‐responsive Hydrogelsmentioning

confidence: 99%

“…In addition to its application in drug release, electric field stimulation also shows promise in chronic wound healing by activating ion channels and downstream transduction signals to guide the proliferation and migration of skin cells and induce angiogenesis and immune modulation for tissue remodelling [50,51]. Wang et al [52] synthesised a conductive hydrogel (ePatch) using silver nanowires and methacrylated alginate as the electrode materials for wound healing. When the ePtach was directly applied to the wound sites and then connected to a pulse width modulation generator, it could significantly promote wound healing and reduce the expression of inflammatory factors under electric field stimulation.…”

Section: Electric Field-responsive Hydrogelsmentioning

confidence: 99%

Recent developments in stimuli‐responsive hydrogels for biomedical applications

Liu

Han

2022

Biosurface and Biotribology

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Hydrogels exhibit a performance similar to that of the extracellular matrix and are compatible with human tissues and organs. Stimuli-responsive hydrogels that can respond smartly to a variety of stimuli have recently attracted extensive interest for biomedical applications. The response of these hydrogels to various single/multiple stimuli shows great potential for drug delivery, biosensors, wound dressing, cancer therapy, and tissue engineering. This review summarises the recent advances in the design of different stimuli-responsive hydrogels and their biomedical applications. We herein describe the mechanisms underlying the stimulus-response, and summarise the strategies for fabricating stimuli-responsive hydrogels that can respond to single or multiple stimuli from endogenous (i.e. pH, enzymes, glucose, and reactive oxygen species) or exogenous (i.e. magnetic and electric fields, temperature, and photo) sources. The current challenges faced by stimuli-responsive hydrogels are discussed and an outlook on future research directions is provided.

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“…83 MXene-based nanomaterials contain MXene nanosheets, 84 PDA-coated MXene nanosheets, 73 and cerium dioxide (CeO 2 )-loaded MXene nanosheets. 71 The representative metal-based nanomaterials include silver (Ag) nanoparticles, [85][86][87][88][89] Ag nanowires, 90 Ag nanoclusters, 91 gold (Au) nanorods, 92 molybdenum disulde (MoS 2 ) nanosheets, [93][94][95] copper sulde (CuS) nanoparticles, 96 zinc oxide (ZnO) nanomaterials, [97][98][99] CeO 2 nanoparticles, 100 and metal-organic frameworks (MOFs). [101][102][103] Moreover, silicon-based nanomaterials include silica nanoparticles, 104,105 polyhedral oligomeric silsesquioxane (POSS), 106 bioactive glass nanoparticles (BGNs) 107 and nanoclay.…”

Section: Introductionmentioning

confidence: 99%