Flexible wireless skin impedance sensing system for wound healing assessment

Pei, Xiachuan; Jin, Hao; Dong, Shurong; Lou, Dong; Ma, Lie; Wang, Xingang; Cheng, Weiwei; Wong, Hei

doi:10.1016/j.vacuum.2019.108808

Cited by 25 publications

(10 citation statements)

References 20 publications

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“…Details of principles and procedures of the fabrication process for the sensor part are mentioned in our previous paper [ 24 ]. Briefly, the sensor is covered by Polydimethylsiloxane (PDMS), with its conductive circuit part printed on the flexible polyimide (PI) substrate.…”

Section: Methodsmentioning

confidence: 99%

Non-Invasive Muscular Atrophy Causes Evaluation for Limb Fracture Based on Flexible Surface Electromyography System

Pei

Yan

Jiang

et al. 2022

Sensors

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Muscular atrophy after limb fracture is a frequently occurring complication with multiple causes. Different treatments and targeted rehabilitation procedures should be carried out based on the causes. However, bedside evaluation methods are invasive in clinical practice nowadays, lacking reliable non-invasive methods. In this study, we propose a non-invasive flexible surface electromyography system with machine learning algorithms to distinguish nerve-injury and limb immobilization-related atrophy. First, a flexible surface electromyography sensor was designed and verified by in vitro tests for its robustness and flexibility. Then, in vivo tests on rats proved the reliability compared with the traditional invasive diagnosis method. Finally, this system was applied for the diagnosis of muscular atrophy in 10 patients. The flexible surface electromyography sensor can achieve a max strain of 12.0%, which ensures close contact with the skin. The in vivo tests on rats show great comparability with the traditional invasive diagnosis method. It can achieve a high specificity of 95.28% and sensitivity of 98.98%. Application on patients reaches a relatively high specificity of 89.44% and sensitivity of 91.94%. The proposed painless surface electromyography system can be an easy and accurate supplementary for bedside muscular atrophy causes evaluation, holding excellent contact with the body.

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Section: Methodsmentioning

confidence: 99%

Non-Invasive Muscular Atrophy Causes Evaluation for Limb Fracture Based on Flexible Surface Electromyography System

Pei

Yan

Jiang

et al. 2022

Sensors

Self Cite

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“…They observed a correlation between impedance and both the healing process and wound types. [ 80 ] Further investigations on the complex relationships between impedances and wounds may bring promising opportunities and improve patient care.…”

Section: Biomarker Sensing and Monitoringmentioning

confidence: 99%

Wearable Bioelectronics for Chronic Wound Management

Wang

Sani

Gao

2021

Adv Funct Materials

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Chronic wounds are a major healthcare issue and can adversely affect the lives of millions of patients around the world. The current wound management strategies have limited clinical efficacy due to labor-intensive lab analysis requirements, need for clinicians' experiences, long-term and frequent interventions, limiting therapeutic efficiency and applicability. The growing field of flexible bioelectronics enables a great potential for personalized wound care owing to its advantages such as wearability, low-cost, and rapid and simple application. Herein, recent advances in the development of wearable bioelectronics for monitoring and management of chronic wounds are comprehensively reviewed. First, the design principles and the key features of bioelectronics that can adapt to the unique wound milieu features are introduced. Next, the current state of wound biosensors and on-demand therapeutic systems are summarized and highlighted. Furthermore, the design criteria of the integrated closed loop devices are discussed. Finally, the future perspectives and challenges in wearable bioelectronics for wound care are discussed.

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“…Furthermore, compared to some currently used materials, such as polyaniline, polypyrrole and polyethylene phthalate, the electrical conductivity may decrease over time due to the reduction in dopants in their physiological environment or loss [ 142 ]. The PDA can maintain a relatively constant conductivity in the physiological solution, which means that it can be combined with the method of measuring the transcutaneous resistance or impedance of the wound every day using electrodes to effectively measure the wound state [ 143 , 144 ], because resistance and impedance both increase with the progress of wound healing. However, the difference between the electrical resistance (impedance) of the conductive biomaterial and the electrical resistance (impedance) of the skin tissue must be carefully considered.…”

Section: Conclusion and Prospectmentioning

confidence: 99%

Performance of Polydopamine Complex and Mechanisms in Wound Healing

Zheng

Huang

Zhu

et al. 2021

IJMS

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Polydopamine (PDA) has been gradually applied in wound healing of various types in the last three years. Due to its rich phenol groups and unique structure, it can be combined with a variety of materials to form wound dressings that can be used for chronic infection, tissue repair in vivo and serious wound healing. PDA complex has excellent mechanical properties and self-healing properties, and it is a stable material that can be used for a long period of time. Unlike other dressings, PDA complexes can achieve both photothermal therapy and electro activity. In this paper, wound healing is divided into four stages: antibacterial, anti-inflammatory, cell adhesion and proliferation, and re-epithelialization. Photothermal therapy can improve the bacteriostatic rate and remove reactive oxygen species to inhibit inflammation. Electrical signals can stimulate cell proliferation and directional migration. With low reactive oxygen species (ROS) levels, inflammatory factors are down-regulated and growth factors are up-regulated, forming regular collagen fibers and accelerating wound healing. Finally, five potential development directions are proposed, including increasing drug loading capacity, optimization of drug delivery platforms, improvement of photothermal conversion efficiency, intelligent electroactive materials and combined 3D printing.

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Flexible wireless skin impedance sensing system for wound healing assessment

Cited by 25 publications

References 20 publications

Non-Invasive Muscular Atrophy Causes Evaluation for Limb Fracture Based on Flexible Surface Electromyography System

Non-Invasive Muscular Atrophy Causes Evaluation for Limb Fracture Based on Flexible Surface Electromyography System

Wearable Bioelectronics for Chronic Wound Management

Performance of Polydopamine Complex and Mechanisms in Wound Healing

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