Flexor Tendon Tissue Engineering: Acellularization of Human Flexor Tendons With Preservation of Biomechanical Properties and Biocompatibility

Pridgen, Brian C.; Woon, Colin YL; Kim, Maxwell Y.; Thorfinn, Johan; Lindsey, Derek P.; Pham, Hūng Viêt; Chang, James

doi:10.1089/ten.tea.2010.0457

Cited by 25 publications

(55 citation statements)

References 51 publications

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“…The classic tissue-engineered products are the allo-or xeno-geneic-based grafts that are processed only by acellularization technologies 15,16,51,52 . Thus, their architecture could not be re-designed in a more effective manner after implantation in the injured tendons 15 .…”

Section: Architecture Of the Scaffoldsmentioning

confidence: 99%

Role of tissue engineering in tendon reconstructive surgery and regenerative medicine: Current concepts, approaches and concerns

Moshiri¹,

Oryan²

2012

Hard Tissue

193

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Section: Architecture Of the Scaffoldsmentioning

confidence: 99%

Role of tissue engineering in tendon reconstructive surgery and regenerative medicine: Current concepts, approaches and concerns

Moshiri¹,

Oryan²

2012

Hard Tissue

193

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“…Comparing auto-to allo-and xenografts options, autografts have better incorporative properties than the other grafts because basically the autografts are viable tissues and their cells can collaborate at different stages of healing [3,[71][72][73]. In addition the resorption rate of autografts are lower than other grafts; therefore the healing in autografts would be faster [3,72].…”

Section: Graft Options In Managing Large and Massive Tendon And Ligammentioning

confidence: 99%

“…sterilization, cell rinsing, freeze drying, etc. ); therefore these types of grafts are not viable in nature because their cellular structures are commonly destroyed during sterilization and other important tissue processing [72][73][74][75][76][77][78][79][80][81][82][83][84][85]. Therefore, it is a fact that the allo-and xenografts have significantly lower incorporative properties with the healing tissue and this is another major limitation which results in rapid absorption of the graft during tendon or ligament healing [69,72].…”

Section: Graft Options In Managing Large and Massive Tendon And Ligammentioning

confidence: 99%

“…This method of tissue engineering has been used for many years to decrease the antigenicity of the viable grafts [68][69][70][71][72]. Newer approaches have been developed by many and newer tissue engineered products are introduced in the recent years [73][74][75][76][77][78][79][80][81][82][83][84][85]. Basically, tissue engineering could be divided into four major categories including tissue scaffolds, healing promotive factors, stem cells and gene therapy [12].…”

Section: Tissue Engineeringmentioning

confidence: 99%

“…Based on the source, tissue scaffolds could be divided into three major categories including biologic, synthetic and hybrid scaffolds [22][23][24]. The acellularized cadaveric tissues or grafts are the most well-known biologic scaffolds [24,[68][69][70][71][72][73][75][76][77][78][79][80][81]. However, the newer ones are those constructed by the biologic based molecules such as collagen, elastin, chitosan, demineralized bone matrix, fibrin, gelatin, hyaluronic acid, chondroitin sulphate, silk, etc [12,[25][26][27][28].…”

Section: Scaffoldsmentioning

confidence: 99%

See 2 more Smart Citations

Tendon and Ligament Tissue Engineering, Healing and Regenerative Medicine

Moshiri¹,

Oryan²

2013

J Sports Med Doping Stud 2013

102

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Tendons transmit forces from muscle to bone and provide the joint function and ligaments transmit forces from bone to bone and provide joint stability. Tendon and ligament injuries have high incidence and management of tendon and ligament injuries is technically demanding because the healing response of these soft connective tissues is low. In addition, number of the available options to be considered as tissue replacement for large defects is low and healing of tendon and ligaments is faced to significant limitations. Among the available options, autografts are still gold standard but all the auto-allo and xenografts have their own limitations. Tissue engineering is a newer option but it is still primitive to be applicable extensively, in clinical setting. Tissue engineering could be divided into four categories including scaffolds, healing promotive factors, stem cells and gene therapy. To be able to have a good judgment regarding the management of tendon and ligament injuries, it is crucial to have a basic knowledge of tendon and ligament healing and regeneration. In this review, we discussed various types of tendon and ligament injuries and their incidence, and introduced the available and future options in managing large and massive tendon and ligament injuries. We specifically discussed the tissue engineering and it's advantageous and disadvantageous. To give a better clarification for the readers, we described different phases and cascades of tendon and ligament healing, modeling and remodeling, host-graft interaction after implantation of the graft and various types of prosthetic implants and finally provided some suggestions for the future investigations.

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Concept of minimum electrospinning voltage in electrospinning of polyacrylonitrile N,N‐dimethylformamide system

Basu

Agrawal

Jassal

2011

J of Applied Polymer Sci

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Polyacrylonitrile solutions in N,N-dimethylformamide (DMF) were electrospun into nanofibers by charging the polymer fluid in an electric field. Controlled experiments were performed using a needle type spinneret to investigate the effect of various electrospinning parameters on the percentage conversion of polymeric fluid into fibers and on fiber diameter obtained. It was found that when the polymeric fluid was continuously fed at a constant rate, application of a minimum electrospinning voltage (MEV) was necessary to ''completely'' convert the ejected fluid into nanojets to form nanofibers. Also, that the maximum amount of splitting or elongation that a polymeric fluid could undergo was primarily dependent on number of entanglements per chain in the fluid. This resulted in obtaining nanofibers with a particular diameter irrespective of the values of important electrospinning variables such as applied voltage, flow rates, and distance between the electrodes. On the other hand, MEV, necessary to obtain full conversion into nanofibers, was found to be strongly dependent on the spinning parameters and was unique for a given set of parameters. The significance of the MEV was evident from the fact that the square of the MEV, which is a measure of the electrical energy utilized by the system, was found to be directly proportional to the rate of formation of fiber surface area during the electrospinning process.

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Flexor Tendon Tissue Engineering: Acellularization of Human Flexor Tendons With Preservation of Biomechanical Properties and Biocompatibility

Cited by 25 publications

References 51 publications

Role of tissue engineering in tendon reconstructive surgery and regenerative medicine: Current concepts, approaches and concerns

Role of tissue engineering in tendon reconstructive surgery and regenerative medicine: Current concepts, approaches and concerns

Tendon and Ligament Tissue Engineering, Healing and Regenerative Medicine

Concept of minimum electrospinning voltage in electrospinning of polyacrylonitrile N,N‐dimethylformamide system

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