Floating Microspheres of Enalapril Maleate as a Developed Controlled Release Dosage Form: Investigation the Effect of Ionotropic Gelation Technique

Abstract

The purpose of this study is to provide a control drug delivery system through a newly approved work to enhance absorption and bioavailability of enalapril maleate loaded floating microspheres by ionotropic gelation technique using a hydrophilic carrier. Methods: Over this study, eleven developed formulations of floating microspheres were prepared by ionotropic gelation method using different concentrations of sodium alginate, iota carrageenan, sodium bicarbonate, calcium chloride, and the drug. Characterization of these microspheres was done using a diversity of parameters like micrometric properties, percentage yield, entrapment efficiency, In-Vitro buoyancy, In-Vitro drug release, and kinetics of drug release. The optimum formula was evaluated and identified for drugexcipients compatibility using Fourier transform infrared spectroscopy (FT-IR), surface morphology, powder X-ray diffraction (PXRD), and differential scanning calorimetry (DSC). Results: From the results; F4 was selected as an optimum formula since it provides a faster and premium release of drug from the matrix (91.4%). Kinetics of drug release was founded to depend on both diffusion and erosion mechanisms, as the correlation coefficient (R 2) was best fitted with Korsemeyer model and release exponent (n) shown to be between 0.43-0.84. SEM images demonstrate spherical, discrete and freely flowing microspheres with a particle size of 199.4 ± 0.04. Optimum buoyancy properties, percentage yield, and drug entrapment efficiency were achieved. FTIR decided no interaction between enalapril and the polymers. DSC and XRD ascribed the miscibility of the drug with the polymers while maintaining stable crystalline properties of enalapril loaded in the prepared microspheres. Conclusion: It can be concluded that the developed floating microspheres of enalapril maleate can be considered as a promising controlled drug delivery system; thereby improve patient compliance.

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“…DSC and XRD showed the miscibility of the drug with the polymers while maintaining the stable crystalline properties of Enalapril loaded in the prepared microspheres. So the developed floating microspheres of Enalapril Maleate can be considered a promising controlled drug delivery system, thereby improving patient compliance 30 . Amul Mishra et al, (2018 Developed a floating Microsphere of Metformin hydrochloride by emulsion solvent evaporation technique using Eudragit S100, Ethylcellulose, Cellulose acetate, HPMC as polymer.…”