Florid Papillomatosis (Adenoma) and other Benign Tumours of the Nipple and Areola

Abstract

The paper deals with 20 benign tumours of the nipple and areola. The most common lesion was adenoma or florid papillomatosis (11 cases). On the basis of clinical and histological differences, the cases were divided into two groups. Group I.—Tumours showing an adenomatous pattern (5 cases) appropriately termed adenoma of the nipple. Chief clinical features were younger age, long duration and enlargement of the nipple as a predominant symptom. Histological characteristics were elongated tubules separated by a varying amount of fibrous stroma and squamous metaplasia in some of the cases. Group II.—Tumours showing a papillomatous pattern (6 cases) appropriately designated as florid papillomatosis. Clinically, the patients were older. Chief complaint was bleeding from the nipple of a few months' duration. Histologically, dilated lactiferous ducts were seen filled with papillary, cribriform and solid growth of cells. Other features such as apocrine metaplasia, foam cells and central necrosis were observed. The interpretation of this grouping is discussed. A case of adenoma of an accessory nipple is reported. Other benign tumours observed were five papillomas, one leiomyoma, one haemangioma, one fibroma and one lipoma. Images Figs. 17-18 Figs. 1-3 Figs. 14-16 Figs. 19-21 Figs. 4-6 Figs. 7-10 Figs. 11-13

Cytology of breast pleomorphic adenoma associated with extensive apocrine metaplasia

“…8 While apocrine metaplasia is often seen in various mammary lesions, apocrine metaplasia seen in our case may reflect the characteristics of the site of origin.…”

Nipple adenoma arising from axillary accessory breast: a case report

“…The tumor was small, eczematous and crusted, and was initially suspected as being an inflammatory disease such as an inflamed epidermal cyst. The present case is only the 3 rd case of nipple adenoma arising from axillary accessory breast to be reported in the English literature, having been reported by Doctor and Shinn [5,10]. …”

“…It was first recognized as a distinctive entity in 1955 by Jones who referred to it as “florid papillomatosis” of the nipple duct [1]. Nipple adenoma, also known as nipple duct adenoma, papillary adenoma, erosive adenomatosis, florid papillomatosis, papillomatosis of the nipple and subareolar duct papillomatosis, is a variant of intraductal papilloma involving the terminal portion of the galactophorous ducts [2-5]. Clinically, nipple adenoma can be mistaken for Paget’s disease and can be interpreted pathologically as a tubular carcinoma.…”

A Case of Erosive Adenomatosis of Nipple Treated with Total Excision Using Purse-String Suture

“…The findings from the immunohistochemical staining were identical to those of the lactiferous ducts, which are structures modified from the apocrine glands 7 . As for the diseases needing histologic differentiation, there are intraductal carcinoma, syringocystadenoma papilliferum, and hidradenoma papilliferum 8,9 …”