Florun Serbest Radikaller, Reaktif Oksijen Türleri ve Oksidatif Stres ile İlişkileri

Kurtdede, Efe; Pekcan, Mert; Karagül, Hilal

doi:10.17094/ataunivbd.326899

Cited by 3 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Free radicals formed in cells consist of reactive oxygen species (ROS) and reactive nitrogen species (RNS). It is produced against degenerative conditions and various physical-chemical stimuli in the organism [21]. The presence of free radicals in medium or low amounts in the environment provides benefits in signaling and immune mechanisms.…”

Section: Free Radicalsmentioning

confidence: 99%

See 1 more Smart Citation

Relationship of Lead With Free Radicals, Reactive Oxygen Species, Oxidative Stress and Antioxidant Enzymes

VURAL AYDIN

2024

Eskişehir Teknik Üniversitesi Bilim Ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji

View full text Add to dashboard Cite

Heavy metals, which are high in the environment, are substances that have a high toxic effect even at low concentrations. Heavy metals taken into the organism through mouth, respiration and skin cannot be eliminated by the body's excretory pathways. In addition, since they have a durable structure, they participate in the food chain and accumulate in various body tissues. With the increase in industrial activities, heavy metal pollution has also emerged and has increased day by day. Lead is an element that is widely used in industry because it has a low melting temperature. However, it is known that lead, like other heavy metals, has an effect on problems such as environmental pollution and health problems. Occupational diseases such as lead poisoning occur as a result of direct exposure to lead. Direct exposure in this way can also cause death. Lead causes undesirable conditions such as increase of reactive oxygen species (ROS), emergence of oxidative stress and weakening of antioxidant system. Lead disrupts the prooxidant/antioxidant ratio. As a result, effects such as an increase in ROS and thus damage to the basic components of the cell such as lipid, protein and nucleic acid are observed.In particular, lead inhibits enzymes and prevents some enzymes from acting as antioxidants. As a result of exposure to lead, there is a decrease in the defense abilities of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), glutathione (GSH) and ascorbic acid in blood and tissues. Lead increases lipid peroxidation and thus causes oxidative damage. Evaluation of the effect of lead at the cellular level is important in terms of developing solutions for the toxic effects of lead. In this study, the effect of lead on the cellular level in the organism and its effects on free radicals, ROS and oxidative stress were evaluated.

show abstract

Section: Free Radicalsmentioning

confidence: 99%

“…In addition, it causes events such as the destruction of the DNA molecule, which results in undesirable situations such as mutagenesis and carcinogenesis. It causes events such as the destruction of the DNA molecule resulting in undesirable situations such as mutagenesis and carcinogenesis [21,22,23].…”

Section: Free Radicalsmentioning

confidence: 99%

Relationship of Lead With Free Radicals, Reactive Oxygen Species, Oxidative Stress and Antioxidant Enzymes

VURAL AYDIN

2024

Eskişehir Teknik Üniversitesi Bilim Ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji

View full text Add to dashboard Cite

show abstract

“…Flor intoksikasyonundan sonra serbest radikaller önemli ölçüde artar. Florun mitokondri üzerindeki toksik etkisi reaktif oksijen türleri (Reaktif Oxigene Species) (ROS) indüksiyonuna ve antioksidan savunmada zayıflamaya yol açar (11).…”

Section: Introductionunclassified

Deneysel Florozis Oluşturulmuş Ratlarda Tedavi ve Koruma Amaçlı Vitamin C ve Vitamin E Uygulamasının Serum Vitamin Düzeyleri Üzerine Etkisi

Öner¹,

Çetin²,

Yörük³

et al. 2021

Atatürk Üniversitesi Veteriner Bilimleri Dergisi

View full text Add to dashboard Cite

Effects of Chitosan and Chitosan Oligosaccharide on Serum and Tissue Sialic Acid Levels in Experimental Fluorosis

Özdek

Değer

2021

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

View full text Add to dashboard Cite

Bu çalışmada deneysel florozisli ratlarda, kitosan (CH) ve kitosan oligosakkaritin (COS), serum ve dokularda (karaciğer, böbrek, beyin ve testis) toplam siyalik asit (TSA) düzeyine etkisi araştırılmıştır. Gruplar kontrol, sodyum florür (NaF), NaF + kitosan (NaF + CH), NaF + kitosan oligosakkarit (NaF + COS), kitosan (CH) ve kitosan oligosakkarit (COS) olarak oluşturuldu. NaF gruplarının içme suyu 100 ppm sodyum florür konsantrasyonunda hazırlandı. Deney gruplarında, doksan gün süreyle kitosan ve kitosan oligosakkarit 250 mg/kg dozunda oral yolla uygulandı. Çalışma sonunda serum ve karaciğer, böbrek, beyin ve testis doku homojenizatlarının TSA düzeyi spektrofotometrik yöntemle belirlendi. Florür uygulanan grupta (NaF), kontrol grubu ile karşılaştırıldığında, serum, karaciğer, böbrek, beyin ve testis dokularında TSA düzeylerinin arttığı görüldü (p<0.05). NaF grubuna göre, NaF+CH grubunda serum seviyelerinde, NaF+COS grubunda ise serum, karaciğer ve böbrek dokularında belirgin düşüş vardı. Beyin dokusu sialik asit düzeyi açısından kontrol ve deney grupları arasında fark olmadığı belirlendi (p>0.05). Sonuç olarak, flor toksikasyonunun, serum ve dokularda hücre hasarına neden olarak, TSA düzeylerinde artışa neden olduğu düşünülebilir. Sunulan çalışmada, CH ve COS'un TSA seviyelerini düşürdüğü gösterilmiştir. Ayrıca bu çalışmada, COS'un TSA seviyesini azaltmada daha etkili olduğu görüldü.

show abstract

Florun Serbest Radikaller, Reaktif Oksijen Türleri ve Oksidatif Stres ile İlişkileri

Cited by 3 publications

References 24 publications

Relationship of Lead With Free Radicals, Reactive Oxygen Species, Oxidative Stress and Antioxidant Enzymes

Relationship of Lead With Free Radicals, Reactive Oxygen Species, Oxidative Stress and Antioxidant Enzymes

Deneysel Florozis Oluşturulmuş Ratlarda Tedavi ve Koruma Amaçlı Vitamin C ve Vitamin E Uygulamasının Serum Vitamin Düzeyleri Üzerine Etkisi

Effects of Chitosan and Chitosan Oligosaccharide on Serum and Tissue Sialic Acid Levels in Experimental Fluorosis

Contact Info

Product

Resources

About