Abstract. Calix[6]arene hydroxamic derivatives were synthesized by two steps using calix [6]arene, ethyl bromoacetate and hydroxylamine hydrochloride as the main raw materials, and were characterized by infrared spectroscopy. The extraction of U(VI) by calix[6]arene and its hydroxamic derivatives on various experimental conditions were studied. The extraction results showed that pH played an important role in the extraction system. Maximum extraction was observed at a pH of 5.0 within 20 min, and the dynamic extraction model corresponded to a pseudo-second order model.