Flow amperometric determination of pharmaceuticals with on-line electrode surface renewal

Flow Analysers

“…This allows parallel or serial monitoring in assays requiring multi-site detection [114,115]. Electrochemical detectors can be re-conditioned when resting in the alternative site [116]. Displacement of a filtering device after passage of the flowing sample [117] is also feasible.…”

Fast and Accurate Analysis of Drugs Using Amperometry Associated With Flow Injection Analysis

“…The analysis of nimesulide on glassy carbon electrodes is hampered by the gradual loss of the electrode activity. To bypass this problem, Catarino et al102 have proposed the use of an FIA‐amperometric system based on the concept of multi‐site location of the detector. The proposed system has allowed the movement of the detection cell between two distinct flow channels.…”

Recent Electrochemical and Optical Sensors in Flow-Based Analysis

“…Moreover, this electrode can also be used to study the electrochemical behaviors of 3,6-dihydroxyphenanthrene in both non-aqueous and aqueous media [23]. The FIA manifold with a relocated detector for renewing the working electrode surface has been reported for the amperometric determination of diltiazem and nimesulide in pharmaceutical formulations [24]. A flow system was constructed with two independent channels based on the concept of multi-site detector locations.…”