To regulate and control microstructure and mechanical properties with the addition of boron, Ti46Al8Nb2.6C0.8TaxB alloys have been produced by casting. Boron content, and its influencing mechanism on the alloy, has been discussed especially in the formation of borides. Experimental results indicate that the content of TiB particles (vol%) increases when the content of boron increases and the B2 phase, in the lamellar colony, disappears. There are three types of boride morphologies discerned in these alloys, which are: granular (C), plate (P), and flake (F) borides. The content of TiB particles (C, vol%) shows a more noticeable increase than in the others. The size of the lamellar colony is refined from 28.4 to 20.8 µm when the content of boron is up to 2.0 at%. Compressive testing indicates that the strength increases from 2191to 2255 MPa and the strain from 26.1 to 28.2% when the content of boron is up to 1.2 at%. Tensile tests reveal that the ultimate strength of the Ti46Al8Nb2.6C0.8Ta0.8B alloy rises from 344to 479 MPa and the corresponding strain rises from 3.9 to 9.1%, when the testing temperature increases from 750to 950 °C. The main reasons for the improved mechanical properties are precipitation strengthening of TiB, disappearance of the B2phase and grain boundary strengthening.