2019
DOI: 10.1007/s10904-019-01346-2
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Flow Behavior and Drug Release Study of Injectable Pluronic F-127 Hydrogels containing Bioactive Glass and Carbon-Based Nanopowders

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Cited by 20 publications
(12 citation statements)
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“…The volume-weighted average diameter (d 43 ) was regarded as the mean diameter for all measurements. Gelatin was used as reference material, and the obscuration was set between 5 and 15% using water as a dispersant at 1300 RPM constant agitation [ 65 , 66 , 67 ].…”
Section: Methodsmentioning
confidence: 99%
“…The volume-weighted average diameter (d 43 ) was regarded as the mean diameter for all measurements. Gelatin was used as reference material, and the obscuration was set between 5 and 15% using water as a dispersant at 1300 RPM constant agitation [ 65 , 66 , 67 ].…”
Section: Methodsmentioning
confidence: 99%
“…44 Before starting the discussion regarding this behavior in the LLC nanostructure, it is required to have an understanding about the LCST behavior of F127, which is observed as a sol− gel transition in aqueous media. 45 When the temperature rises to 25−37 °C, hydrophobicity of the PPO block increases, which results in aggregation of PPO chains and thus formation of the core of the micelles. In addition, PEO chains form a packed interconnected micelle corona, resulting in the formation of a gel.…”
Section: Mwcomentioning
confidence: 99%
“…This transition can be reversed by cooling down the formed gel. 45 Therefore, the PPO block is mainly responsible for the LCST behavior of F127 around 25−37 °C. In the reported studies on LLCs and polyLLCs created by Pluronic surfactants, the PPO block is suggested to be oriented toward the apolar domain.…”
Section: Mwcomentioning
confidence: 99%
“…BG is a surface-active bioceramics, with non-toxicity, non-inflammatory, and osteogenic potential that can firmly bond with bone and induce hard and soft tissue regeneration [ 3 , 4 , 5 ]. BG is also safe and stable in the human body [ 6 , 7 ]; thereby, BG is widely used in clinical application in dentistry, orthopedics, and biomedical engineering, such as bone replacement, tooth repair, and drug-carrying materials [ 8 , 9 , 10 , 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…Scholars introduced the idea of adding polymer surfactant, such as P-123 (EO 20 PO 70 EO 20 ) or F-127(EO 106 PO 70 EO 106 ), as a structural template to fabricate mesoporous bioactive glass (MBG) to increase the specific surface area of BG effectively [ 18 , 19 , 20 ]. MBG possessing hollow, porous structure, and high specific surface area not only exhibits excellent bioactivities but also serves as drugs or bioactive molecular carriers [ 11 , 21 , 22 ]. Nevertheless, both P-123 and F-127 have non-single composition and are copolymers of PPO-PEO [PEO, poly(ethylene oxide); PPO, poly(propylene oxide)] contains lipophilic and hydrophilic polymers, thus, it is difficult conducting a subtle examination of the surfactants’ physical properties [ 19 , 20 ].…”
Section: Introductionmentioning
confidence: 99%