Flow behavior of a surfactant—oil—water system

Otsubo, Yasufumi; Prud'homme, Robert Krafft

doi:10.1016/0166-6622(89)80013-7

Cited by 3 publications

(3 citation statements)

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“…In the simulations, the density of the 20% Triton X‐100 solution added to the vessel as well as the density at any mixture with other intermediate concentrations were calculated with a simple additive mixing rule of the densities of the pure materials. As for viscosity, Triton X‐100 and its solutions in water can be generally considered as non‐Newtonian fluids (Otsubo & Prud'homme, 1989). However, Triton X‐100 was shown to behave as a Newtonian fluid at low concentrations (less than 30% w/w) and high concentration regime (greater than 60% w/w) (Otsubo & Prud'homme, 1989).…”

Section: Numerical Studymentioning

confidence: 99%

“…As for viscosity, Triton X‐100 and its solutions in water can be generally considered as non‐Newtonian fluids (Otsubo & Prud'homme, 1989). However, Triton X‐100 was shown to behave as a Newtonian fluid at low concentrations (less than 30% w/w) and high concentration regime (greater than 60% w/w) (Otsubo & Prud'homme, 1989). During the mixing process, the kinematic viscosity of the Triton X‐100‐water mixture at any location in the system was then assumed to be expressed by the following equation:

{\nu }_{{mix}}={\chi }_{{water}}\frac{{\eta }_{{water}}}{{\rho }_{{water}}}+(1-{\chi }_{{water}})\frac{{\eta }_{{Triton}}}{{\rho }_{{Triton}}}

where

{\chi }_{{water}}

is the weight fraction of water at that location.…”

Section: Numerical Studymentioning

confidence: 99%

“…As for viscosity, Triton X-100 and its solutions in water can be generally considered as non-Newtonian fluids (Otsubo & Prud'homme, 1989). However, Triton X-100 was shown to behave as a Newtonian fluid at low concentrations (less than 30% w/w) and high concentration regime (greater than 60% w/w) (Otsubo & Prud'homme, 1989). During the mixing process, the kinematic viscosity of the Triton X-100-water mixture at any location in the system was then assumed to be expressed by the following equation: formation of hexagonal liquid crystalline, which consists of anisotropic micelles (Almgren et al, 1986).…”

Section: Fluid Propertiesmentioning

confidence: 99%

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Computational prediction of blend time in a large‐scale viral inactivation process for monoclonal antibodies biomanufacturing

Sirasitthichoke

Hoang

Phalak

et al. 2022

Biotech & Bioengineering

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Viral inactivation (VI) is a process widely used across the pharmaceutical industry to eliminate the cytotoxicity resulting from trace levels of viruses introduced by adventitious agents. This process requires adding Triton X‐100, a non‐ionic detergent solution, to the protein solution and allowing sufficient time for this agent to inactivate the viruses. Differences in process parameters associated with vessel designs, aeration rate, and many other physical attributes can introduce variability in the process, thus making predicting the required blending time to achieve the desired homogeneity of Triton X‐100 more critical and complex. In this study we utilized a CFD model based on the lattice Boltzmann method (LBM) to predict the blend time to homogenize a Triton X‐100 solution added during a typical full‐scale commercial VI process in a vessel equipped with an HE‐3‐impeller for different modalities of the Triton X‐100 addition (batch vs. continuous). Although direct experimental progress of the blending process was not possible because of GMP restrictions, the degree of homogeneity measured at the end of the process confirmed that Triton X‐100 was appropriately dispersed, as required, and as computationally predicted here. The results obtained in this study were used to support actual production at the biomanufacturing site.

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Section: Numerical Studymentioning

confidence: 99%