Flow chemistry of main group and transition metal complexes

Scattolin, Thomas; Simoens, Andreas; Stevens, Christian V.; Nolan, Steven P.

doi:10.1016/j.trechm.2022.04.001

Cited by 9 publications

(2 citation statements)

References 123 publications

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“…[6] It should come as no surprise that these characteristics have cemented its use in modern-day chemistry including organometallics. [7] Although solids are often men-tioned as the Achilles-heel of flow chemistry, when a wellcontrolled system is built with capable pumps, the use of packed beds or solid supported catalysts can help to make heterogeneous reactions much more efficient and sustainable as well as opening the door to telescoping opportunities. [8] Recently, the prominent fields of N-heterocyclic carbenes and flow chemistry were harmoniously combined to apply the weak-base method in a continuous setup.…”

Section: Introductionmentioning

confidence: 99%

“…The benefits this entails for reproducibility, selectivity, ease of scale‐up and telescoping are well documented [6] . It should come as no surprise that these characteristics have cemented its use in modern‐day chemistry including organometallics [7] . Although solids are often mentioned as the Achilles‐heel of flow chemistry, when a well‐controlled system is built with capable pumps, the use of packed beds or solid supported catalysts can help to make heterogeneous reactions much more efficient and sustainable as well as opening the door to telescoping opportunities [8]…”

Section: Introductionmentioning

confidence: 99%

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Continuous Flow Synthesis of Group 11 Metal‐NHC Complexes [M(IPr)(OC(H)(CF₃)₂)] (with M=Cu, Ag and Au)

Simoens,

Carì,

Ostrowska

et al. 2024

Asian J Org Chem

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The weak base method in continuous flow is one of the most sustainable and attractive approaches towards the synthesis of transition metal NHC complexes. Herein, we broaden the scope of this method by deploying it to synthesize [M(IPr)(OC(H)(CF3)2)] complexes, including copper, silver, and gold‐centered complexes. These compounds bear an alkoxide ligand which can create new opportunities in harnessing the unique properties of HFIP (1,1,1,3,3,3‐hexafluoroisopropanol) in catalysis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Continuous Flow Synthesis of Group 11 Metal‐NHC Complexes [M(IPr)(OC(H)(CF₃)₂)] (with M=Cu, Ag and Au)

Simoens,

Carì,

Ostrowska

et al. 2024

Asian J Org Chem

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Continuous Flow Synthesis of α‐Chloroketones from Esters

Brassart,

Manneveau,

Poisson

et al. 2025

Adv Synth Catal

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Herein, we report a novel and practical strategy to access α‐chloroketones from esters bearing diverse (hetero)aromatic, aliphatic, alkynyl and alkenyl substituents with transient chloromethyllithium under continuous flow conditions. This highly chemoselective method enables a fast (on a time scale of <5 s), efficient and straightforward access to a broad substrate scope (up to 99% yield) with a remarkable throughput of ∼10.6 g/h.

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Gold(I)‐N‐Heterocyclic Carbene Synthons in Organometallic Synthesis

Scattolin

Tonon

Botter

et al. 2023

Chemistry A European J

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The prominent role of gold‐N‐heterocyclic carbene (NHC) complexes in numerous research areas such as homogeneous (photo)catalysis, medicinal chemistry and materials science has prompted organometallic chemists to design gold‐based synthons that permit access to target complexes through simple synthetic steps under mild conditions. In this review, the main gold‐NHC synthons employed in organometallic synthesis are discussed. Mechanistic aspects involved in their synthesis and reactivity as well as applications of gold‐NHC synthons as efficient pre‐catalysts, antitumor agents and/or photo‐emissive materials are presented.

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Flow chemistry of main group and transition metal complexes

Cited by 9 publications

References 123 publications

Continuous Flow Synthesis of Group 11 Metal‐NHC Complexes [M(IPr)(OC(H)(CF₃)₂)] (with M=Cu, Ag and Au)

Continuous Flow Synthesis of Group 11 Metal‐NHC Complexes [M(IPr)(OC(H)(CF₃)₂)] (with M=Cu, Ag and Au)

Continuous Flow Synthesis of α‐Chloroketones from Esters

Gold(I)‐N‐Heterocyclic Carbene Synthons in Organometallic Synthesis

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Flow chemistry of main group and transition metal complexes

Cited by 9 publications

References 123 publications

Continuous Flow Synthesis of Group 11 Metal‐NHC Complexes [M(IPr)(OC(H)(CF3)2)] (with M=Cu, Ag and Au)

Continuous Flow Synthesis of Group 11 Metal‐NHC Complexes [M(IPr)(OC(H)(CF3)2)] (with M=Cu, Ag and Au)

Continuous Flow Synthesis of α‐Chloroketones from Esters

Gold(I)‐N‐Heterocyclic Carbene Synthons in Organometallic Synthesis

Contact Info

Product

Resources

About

Continuous Flow Synthesis of Group 11 Metal‐NHC Complexes [M(IPr)(OC(H)(CF₃)₂)] (with M=Cu, Ag and Au)

Continuous Flow Synthesis of Group 11 Metal‐NHC Complexes [M(IPr)(OC(H)(CF₃)₂)] (with M=Cu, Ag and Au)