Flow control in fully enclosed microfluidics paper based analytical devices using plasma processes

Raj, Nikhil; Breedveld, Victor; Hess, Dennis W.

doi:10.1016/j.snb.2020.128606

Cited by 21 publications

(10 citation statements)

References 47 publications

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“…Despite this relatively simple and easy fabrication, these 3D-µPADs often suffer from leakage of sample solution due to adhesion failure or contaminated channels by melted adhesive. To avoid these problems, researchers have developed several methods to fabricate 3D-µPADs with enclosed channels without extra assembly steps using either wax printing [12][13][14] or plasma deposition with etching [15,16]. The wax printing-based method is very useful for the rapid fabrication of enclosed channels.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Sensing Behavior of Three-Dimensional Microfluidic Paper-Based Analytical Devices (3D-μPADs) with Evaporation-Free Enclosed Channels for Point-of-Care Testing

2021

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Despite the potential in fabrication of microfluidic paper-based analytical devices (μPADs) for point-of-care testing (POCT) kits, the development of simple, accurate, and rapid devices with higher sensitivity remains challenging. Here, we report a novel method for 3D-μPAD fabrication with enclosed channels using vat photopolymerization to avoid fluid evaporation. In detail, height of the enclosed channels was adjusted from 0.3 to 0.17 mm by varying the UV exposure time from 1 to 4 s for the top barrier, whereas the exposure time for the bottom and side barriers was fixed. As a result, sample flow in the enclosed channels of 3D-μPADs showed lesser wicking speed with very scant evaporation compared to that in the hemi channels in the 3D-μPADs. The stoppage of evaporation in the enclosed channels significantly improved the gray intensity and uniformity in the detection zone of the 3D-μPADs, resulting in as low as 0.3 mM glucose detection. Thus 3D-μPADs with enclosed channels showed enhanced sensitivity compared to the 3D-μPADs with hemi channels when dealing with a small volume sample. Our work provides a new insight into 3D-μPAD design with enclosed channels, which redefines the methodology in 3D printing.

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Section: Introductionmentioning

confidence: 99%

Enhanced Sensing Behavior of Three-Dimensional Microfluidic Paper-Based Analytical Devices (3D-μPADs) with Evaporation-Free Enclosed Channels for Point-of-Care Testing

2021

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“…Analytical application of µPAD are in, mass spectrometry [213,214] separation methods [215], flow control [216][217][218], electronic integration [219] physical integration [220], chemical integration [221], paper-based microfluidics for diagnostics [199], use of paper microfluidics in blood grouping [222], glucose detection [223], 3D devices for glucose detection [224] and environmental and food safety tests [225]. The μPAD is divided into three parts: sensing (6.5 mm diameter), substrate (6.5 mm diameter), and water addition (11 mm diameter).…”

Section: Solin Et Al [212]mentioning

confidence: 99%

Cellulose through the Lens of Microfluidics: A Review

Moud

2022

Applied Biosciences

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Cellulose, a linear polysaccharide, is the most common and renewable biopolymer in nature. Because this natural polymer cannot be melted (heated) or dissolved (in typical organic solvents), making complicated structures from it necessitates specialized material processing design. In this review, we looked at the literature to see how cellulose in various shapes and forms has been utilized in conjunction with microfluidic chips, whether as a component of the chips, being processed by a chip, or providing characterization via chips. We utilized more than approximately 250 sources to compile this publication, and we sought to portray cellulose manufacturing utilizing a microfluidic system. The findings reveal that a variety of products, including elongated fibres, microcapsules, core–shell structures and particles, and 3D or 2D structured microfluidics-based devices, may be easily built utilizing the coupled topics of microfluidics and cellulose. This review is intended to provide a concise, visual, yet comprehensive depiction of current research on the topic of cellulose product design and understanding using microfluidics, including, but not limited to, paper-based microfluidics design and implications, and the emulsification/shape formation of cellulose inside the chips.

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“…Paper based microfluidic devices, also called microfluidic paper‐based analytical devices (μ‐PADs), are micro analysis systems built by paper instead of the commonly used polymeric materials, like polydimethylsiloxane (PDMS) and polymethyl methacrylate (PMMA) [25,26] . μ‐PADs are simple, economical, portable and have the potential to be used for point‐of‐care diagnostics [27,28] . μ‐PADs have been used for chromatographic separation and coupled with electrochemical detection for the analysis of small molecules, e. g. paracetamol, 4‐aminophenol, ascorbic acid, and uric acid [29,30] …”

Section: Introductionmentioning

confidence: 99%

“…[25,26] μ-PADs are simple, economical, portable and have the potential to be used for point-of-care diagnostics. [27,28] μ-PADs have been used for chromatographic separation and coupled with electrochemical detection for the analysis of small molecules, e. g. paracetamol, 4-aminophenol, ascorbic acid, and uric acid. [29,30] Herein, a microfluidic free-flow paper electrochromatography (μ-FFPE) chip was developed by adding commercial filter paper into the separation cavity of μ-FFE.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Free‐Flow Paper Electrochromatography for Continuous Separation of Glycans

Liu

Huang

et al. 2022

ChemElectroChem

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Microfluidic free-flow electrophoresis (μ-FFE) is widely used for continuous separation of charged analytes. However, μ-FFE is limited in the separation of analytes with the same electrophoretic mobility. In this work, we developed a novel microfluidic free-flow paper electrochromatography (μ-FFPE) by combining μ-FFE with filter paper-based chromatography, enabling continuous separation of analytes through the mechanism of both μ-FFE and paper chromatography. Numerical simulation was applied to demonstrate the advantages of adding filter paper as the stationary phase of μ-FFE. With the filter paper, a more stable separation system was achieved. The device was applied to the separation of simple mixtures of dyes and complex mixtures of glycans. With the μ-FFPE fractionation, much more glycans and glycan types can be identified by LC-MS, demonstrating the value of the method in biological analysis. The μ-FFPE can provide a new platform for the separation and analysis of various biological molecules.

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Flow control in fully enclosed microfluidics paper based analytical devices using plasma processes

Cited by 21 publications

References 47 publications

Enhanced Sensing Behavior of Three-Dimensional Microfluidic Paper-Based Analytical Devices (3D-μPADs) with Evaporation-Free Enclosed Channels for Point-of-Care Testing

Enhanced Sensing Behavior of Three-Dimensional Microfluidic Paper-Based Analytical Devices (3D-μPADs) with Evaporation-Free Enclosed Channels for Point-of-Care Testing

Cellulose through the Lens of Microfluidics: A Review

Microfluidic Free‐Flow Paper Electrochromatography for Continuous Separation of Glycans

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