Flow cytometric DNA analysis of hepatic tumours on ultrasound‐guided fine‐needle aspirates

Russo, Antonio; Bazan, Viviana; Plaja, Sergio; Cajozzo, Massimo; Bazan, P

doi:10.1002/jso.2930510109

Cited by 5 publications

References 15 publications

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Ancillary studies in fna of liver and pancreas

Silverman

Geisinger

1995

Diagnostic Cytopathology

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biopsy of the liver and pancreas is the evaluation of mass lesions. In the majority of FNA biopsies from both sites, an accurate diagnosis can be rendered based on cytologic features. However, in occasional cases, ancillary studies can prove quite useful in making a specific diagnosis. Although ancillary studies have a limited to nonexistent role in the FNA evaluation of most benign liver lesions, it can be quite helpful in differentiating primary liver neoplasms from metastatic malignancies. A discussion of the role of ancillary studies in the workup of both common and unusual liver malignancies will be presented. In pancreatic aspirates, ancillary studies are generally not needed for the diagnosis of the common, ductal type of pancreatic carcinoma. However, special studies such as immunocytochemistry and electron microscopy can be valuable in the workup of a variety of unusual pancreatic neoplasms as well as in the diagnosis of metastatic malignancies to the pancreas. Ancillary studies including biochemical assays for carcinoernbryonic antigen (CEA) and amylase can contribute to examination of cystic lesions of the pancreas.We recommend performance of an immediate interpretation to identify those selected cases benefiting from additional ancillary studies. I s 2 The following is a discussion of the role of ancillary studies in the FNA work of hepatic and pancreatic lesions. LiverThe major indication for FNA of the liver is in the evaluation of a hepatic mass. 3-16 In a number of large series of hepatic aspirates, most patients have had metastatic malignancies, although some recent papers report the accuracy of FNA biopsy for the diagnosis of primary

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Ancillary studies in fna of liver and pancreas

Silverman

Geisinger

1995

Diagnostic Cytopathology

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Flow cytometry of liver fine needle aspirates

Fuhr

Kattine

Nelson

1994

Journal of Surgical Oncology

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Fine needle aspiration analysis of intraabdominal masses is increasing in frequency. This study was designed to evaluate whether flow cytometry could be of value in the cytopathology interpretation of such specimens. Over a 4-year time span, 129 consecutive liver fine needle aspirates were evaluated by flow cytometry for DNA content, ploidy, and proliferation rate. Only excess cells remaining in the needle after cytology samples were prepared were included in this study. Overall sensitivity was 75% and specificity was 94%. In addition, flow cytometry results were pivotal for at least two specimens in achieving the appropriate diagnosis. For these reasons, it was concluded that flow cytometry could be a valuable adjunctive technology, to the cytopathologist in the interpretation of liver fine needle aspirates.

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Liver and spleen

Boer¹

2012

Orell and Sterrett's Fine Needle Aspiration Cytology

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Flow cytometric DNA analysis of hepatic tumours on ultrasound‐guided fine‐needle aspirates

Cited by 5 publications

References 15 publications

Ancillary studies in fna of liver and pancreas

Ancillary studies in fna of liver and pancreas

Flow cytometry of liver fine needle aspirates

Liver and spleen

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