Liver and spleen

Boer, Bastiaan de

doi:10.1016/b978-0-7020-3151-9.00010-4

Cited by 2 publications

(6 citation statements)

References 179 publications

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“…The only absolute contraindications are marked haemorrhagic diathesis and suspected vascular lesion. [1,3,5,6] We studied and evaluated the different features in different lesions. At one end of the spectrum, the tumor is well differentiatedit resembles liver but does not look obviously malignant, hence needs to be excluded from benign lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly HCC was differentiated from other nonmalignant conditions of liver by the different features collectively like cellularity, acinar pattern, trabecular pattern, hyperchromasia, uniformly prominent nucleoli, multiple nucleoli and atypical naked nuclei as described. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] The most important and helpful cytological features were the trabecular pattern, irregularly granular chromatin, multiple nucleoli & atypical naked nuclei. The atypical naked nuclei were included as one of the important criteria for the diagnosis of HCC as these were rarely seen in benign and metastatic conditions.…”

Section: Discussionmentioning

confidence: 99%

“…The atypical naked nuclei were included as one of the important criteria for the diagnosis of HCC as these were rarely seen in benign and metastatic conditions. [1,12,15,21] A markedly elevated serum AFP level and the finding of a single lesion with or without satellite lesions on imaging favoured a primary tumor over metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

“…For this reason, this constitutes a potential source of false positive error. [1,7] Cytologically, bile production, as evidenced by the presence of bile in the cytoplasm of malignant cells or in canaliculi between malignant cells, is considered diagnostic of HCC. Unfortunately bile is present in only half of the cases.…”

Section: Discussionmentioning

confidence: 99%

“…Accuracy of FNAC is higher using radiological guidance since the lesion can be localised and multiple samples can be obtained and hence enhancing the chances of obtaining a representative sample. [1,2,3,4] This study was undertaken to assess the role of Ultrasonographic (USG) guided FNAC in the diagnosis of hepatic masses.…”

Section: Introductionmentioning

confidence: 99%

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Utility of Ultrasonographically Guided Fine Needle Aspiration Cytology in the Diagnosis of Hepatic Masses

Prema

Abdulla

2018

ijirms

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Background: With technological advances in imaging, previously inaccessible lesions can now be safely sampled by Fine Needle Aspiration Cytology (FNAC) under radiological guidance. It is also possible to ensure a more accurate diagnostic yield often providing an unequivocal diagnosis in both neoplastic and nonneoplastic conditions. This study was done to assess the role of Ultrasonographic (USG) guided FNAC in the evaluation of hepatic masses. Methodology: USG-guided FNAC was done in patients with hepatic masses. The smears made were stained by the Papanicolaou stain and the cytological features were studied. Relevant clinical data and laboratory investigations which corroborated the diagnosis were recorded. Results: A total of 90 liver aspirates were included in the study. Out of these there were 29 cases of hepatocellular carcinoma. In all the cases except one, the serum alpha fetoprotein levels were found to be elevated. There were 49 cases of metastatic tumors, in which the primary site was not known in 15 cases. The morphology of these secondary tumors was that of an adenocarcinoma. In the remaining 34 cases the primary tumor was found in various organs including the lung, pancreas, stomach, small intestine, breast, ovary, oral cavity and thyroid. There were six non-neoplastic lesions including regenerative nodules, hydatid cyst, tuberculosis, and abscess. In six cases the material was inadequate for definite diagnosis. Conclusion: USG-guided FNAC is a rapid, inexpensive and relatively safe technique for making a cytological diagnosis. A high degree of accuracy due to precise localization of the needle can be achieved and requires close co-operation between the clinician, the radiologist and the pathologist.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Utility of Ultrasonographically Guided Fine Needle Aspiration Cytology in the Diagnosis of Hepatic Masses

Prema

Abdulla

2018

ijirms

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Immunohistochemistry on cell blocks for diagnosis of malignancy in abdomino-pelvic lesions and ascitic fluid cytology at a rural cancer center

Bansal

Sancheti

Sali

et al. 2022

Journal of Cancer Research and Therapeutics

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Background: Cell block preparation is routine practice in cytopathology these days because of its pivotal role in increasing diagnostic yield and ancillary studies. In the present era of personalized medicine in oncology, ancillary techniques such as immunohistochemistry (IHC) and molecular analysis are gaining more importance. Methods: A retrospective study was conducted in the Department of Pathology, over 6 months, which included 144 cases of Fine Needle Aspiration Cytology (FNAC) of abdominopelvic masses and 105 cases of ascitic fluids. Cell blocks and conventional smears were prepared simultaneously in all cases. IHC was applied on cell blocks and analyzed. Results: IHC was performed on cell blocks in 76 cases of FNA and 53 cases of ascitic fluids. Based on IHC, liver lesions (50 cases) were categorized into metastatic carcinomas with a suggested primary site (45.0%), hepatocellular carcinoma (12.2%), neuroendocrine tumors (16.3%), and malignant melanoma (2%). Using MOC-31 and WT-1, ascitic fluid samples were categorized into benign and malignant. Forty-one out of 53 cases of fluids were diagnosed as metastatic adenocarcinomas with the ovary as the most common primary site. Conclusion: A panel of IHC markers, though not specific alone when applied to cell blocks in a careful clinical and morphological context leads to a rapid and accurate diagnosis. This in turn obviates the need for biopsy in severely ill patients. An astute pathologist can provide accurate results with judicious use of IHC on cell blocks and may bring a sigh of relief for many cancer patients by averting the need for biopsy.

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Liver and spleen

Cited by 2 publications

References 179 publications

Utility of Ultrasonographically Guided Fine Needle Aspiration Cytology in the Diagnosis of Hepatic Masses

Utility of Ultrasonographically Guided Fine Needle Aspiration Cytology in the Diagnosis of Hepatic Masses

Immunohistochemistry on cell blocks for diagnosis of malignancy in abdomino-pelvic lesions and ascitic fluid cytology at a rural cancer center

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