1993
DOI: 10.1016/0248-4900(93)90115-u
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Flow cytometry: A useful technique in the study of multidrug resistance

Abstract: Flow cytometry has recently become a very important tool in the study of the mechanisms of multidrug resistance (MDR). This technique allows rapid access to information regarding two characteristics related to the MDR phenotype: i) the level of overexpression of the P-glycoprotein; and ii) its functional aspect in expulsion of the cytotoxic agents to which the cell is exposed. In pharmacology, flow cytometry also allows evaluation of the capacity of modulating agents to reverse this resistance, and contributes… Show more

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Cited by 11 publications
(3 citation statements)
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“…This methodology allows for the accumulation of fluorescent substrates by cells to be followed on a real time basis. FCM has been widely used for studying MDR [15]. It is a novel approach for examining the response of unicellular organisms such as Tetrahymena when they are exposed to environmental contaminants [2].…”
Section: Discussionmentioning
confidence: 99%
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“…This methodology allows for the accumulation of fluorescent substrates by cells to be followed on a real time basis. FCM has been widely used for studying MDR [15]. It is a novel approach for examining the response of unicellular organisms such as Tetrahymena when they are exposed to environmental contaminants [2].…”
Section: Discussionmentioning
confidence: 99%
“…This may explain the larger accumulation of Rhod under these conditions. The cytotoxic drug ADR, an antracyclin highly associated with resistance mechanisms, has the advantage of being fluorescent [6,15]. The uptake of ADR followed in T. pyriformis showed a rapid cellular accumulation of this product reaching levels that remained stable.…”
Section: Discussionmentioning
confidence: 99%
“…Flow cytometry has been used recently to study the effect of various agents against microbes as well as pathogenic prokaryotes and eukaryotes (Fouchet et al 1993;Leonce & Burbridge 1993). Saul et al (1982) successfully used PI to detect and count Plasmodium falciparum infected cells by flow cytometry.…”
Section: Discussionmentioning
confidence: 99%