Flow-injection chemiluminescence determination of chrysin and baicalein assisted by theoretical prediction of chemiluminescence behavior of chrysin and baicalein

Abstract

In this paper, the molecular connectivity indices were applied to theoretically predict the direct chemiluminescence (CL) behavior of chrysin and baicalein with our recently proposed discriminant function. Then, combined with flow-injection analysis, a new CL system for determination of chrysin and baicalein was proposed. The method was based on the oxidation of chrysin and baicalein by acidic KMnO(4) in the presence of formaldehyde to produce strong CL emission. The present paper suggested a new model to discover new CL analytical system: first, to theoretical predict the CL behavior, and the second, to suggest analytical system.

Sensitive Voltammetric Determination of Baicalein at Thermally Reduced Graphene Oxide Modified Glassy Carbon Electrode

“…Repetitive measurements of 1.0 mM baicalein showed good reproducibility with a relative standard deviation (RSD) of 3.1 % (n = 11), and RSD was 4.0 % for five electrodes. These values are better than the reported optical method [8,9], chromatography method [11,12] and capillary electrophoresis method [13,14]. In addition, they are comparable with those of electrochemical sensors based on double stranded DNA-octadecylamine LangmuirÀBlodgett films [15] and carbon paste electrodes doped with carbon nanotubes [16] in strongly acidic buffer solution.…”

“…Therefore, the accurate determination of baicalein is an important and significant work in practice. Some of the analytical methods including UV-vis spectrophotometry [8], flow-injection chemiluminescence [9], thin layer chromatography [10], high performance liquid chromatography [11,12], capillary electrophoresis [13,14] and voltammetry [15,16] have been applied to determine baicalein. Nevertheless, most of these methods required complicated sample preparation, or suffered from low sensitivities and strong acidic analysis system.…”

Electrochemical sensor for Baicalein using a carbon paste electrode doped with carbon nanotubes

“…Therefore, the accurate determination of Baicalein is an important and significant work in clinical. Some of the analytical methods include flow-injection chemiluminescence [9], thin layer chromatography [10], high performance liquid chromatography [11,12] and capillary electrophoresis [13,14]. Nevertheless, these methods either required complicated sample preparation, or suffered from low sensitivities and specificities.…”

Revisiting flow‐chemiluminescence techniques: pharmaceutical analysis

“…used molecular connectivity to predict the CL behavior of chrysin and baicalein, and then proposed a flow‐injection CL procedure for the determination of chrysin and baicalein . Molecular connectivity is a topological method, which can describe the chemical structure of a molecule by means of numbers referred to as ‘indices’ . The advantage of this method is that it needs only knowledge of chemical structure.…”