Flow of a blood analogue fluid in a compliant abdominal aortic aneurysm model: Experimental modelling

Deplano, Valérie; Knapp, Yannick; Bailly, Lucie; Bertrand, Éric

doi:10.1016/j.jbiomech.2014.02.026

Cited by 46 publications

(42 citation statements)

References 24 publications

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“…This will likely be a challenging task. In vitro blood flow measurements in large arteries have been carried out using particle image velocimetry to study shear-thinning effects [64]. However, these studies use blood-analogue fluids that cannot model RBC aggregation and rouleaux formation.…”

Section: Discussionmentioning

confidence: 99%

Accounting for residence-time in blood rheology models: do we really need non-Newtonian blood flow modelling in large arteries?

Arzani¹

2018

J. R. Soc. Interface.

105

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Patient-specific computational fluid dynamics (CFD) is a promising tool that provides highly resolved haemodynamics information. The choice of blood rheology is an assumption in CFD models that has been subject to extensive debate. Blood is known to exhibit shear-thinning behaviour, and non-Newtonian modelling has been recommended for aneurysmal flows. Current non-Newtonian models ignore rouleaux formation, which is the key player in blood's shear-thinning behaviour. Experimental data suggest that red blood cell aggregation and rouleaux formation require notable red blood cell residence-time (RT) in a low shear rate regime. This study proposes a novel hybrid Newtonian and non-Newtonian rheology model where the shear-thinning behaviour is activated in high RT regions based on experimental data. Image-based abdominal aortic and cerebral aneurysm models are considered and highly resolved CFD simulations are performed using a minimally dissipative solver. Lagrangian particle tracking is used to define a backward particle RT measure and detect stagnant regions with increased rouleaux formation likelihood. Our novel RT-based non-Newtonian model shows a significant reduction in shear-thinning effects and provides haemodynamic results qualitatively identical and quantitatively close to the Newtonian model. Our results have important implications in patient-specific CFD modelling and suggest that non-Newtonian models should be revisited in large artery flows.

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Section: Discussionmentioning

confidence: 99%

Accounting for residence-time in blood rheology models: do we really need non-Newtonian blood flow modelling in large arteries?

Arzani¹

2018

J. R. Soc. Interface.

105

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“…Such studies were performed with Newtonian blood analogues composed of mixtures of glycerol and water, [30][31][32][33][34] and others have used non-Newtonian fluids composed of an aqueous solution of xanthan gum (XG) or/and polyacrylamide (PAA), diluted in water or/and glycerine. 35,36 CampoDeaño et al 37 have successfully developed whole blood analogues based on sucrose and dimethylsulfoxide with XG having viscosity curves and viscoelastic moduli similar to whole human blood and in addition demonstrated that these analogues are suitable to be used in polydymethylsiloxane (PDMS) microfluidic devices due to their refractive index matching.…”

Section: Introductionmentioning

confidence: 99%

In vitro particulate analogue fluids for experimental studies of rheological and hemorheological behavior of glucose-rich RBC suspensions

et al. 2017

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Suspensions of healthy and pathological red blood cells (RBC) flowing in microfluidic devices are frequently used to perform in vitro blood experiments for a better understanding of human microcirculation hemodynamic phenomena. This work reports the development of particulate viscoelastic analogue fluids able to mimic the rheological and hemorheological behavior of pathological RBC suspensions flowing in microfluidic systems. The pathological RBCs were obtained by an incubation of healthy RBCs at a high concentration of glucose, representing the pathological stage of hyperglycaemia in diabetic complications, and analyses of their deformability and aggregation were carried out. Overall, the developed in vitro analogue fluids were composed of a suspension of semi-rigid microbeads in a carrier viscoelastic fluid made of dextran 40 and xanthan gum. All suspensions of healthy and pathological RBCs, as well as their particulate analogue fluids, were extensively characterized in steady shear flow, as well as in small and large amplitude oscillatory shear flow. In addition, the well-known cell-free layer (CFL) phenomenon occurring in microchannels was investigated in detail to provide comparisons between healthy and pathological in vitro RBC suspensions and their corresponding analogue fluids at different volume concentrations (5% and 20%). The experimental results have shown a similar rheological behavior between the samples containing a suspension of pathological RBCs and the proposed analogue fluids. Moreover, this work shows that the particulate in vitro analogue fluids used have the ability to mimic well the CFL phenomenon occurring downstream of a microchannel contraction for pathological RBC suspensions. The proposed particulate fluids provide a more realistic behavior of the flow properties of suspended RBCs when compared with existing non-particulate blood analogues, and consequently, they are advantageous for detailed investigations of microcirculation.

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“…The carotid bifurcation is a common focus for hemodynamics research, due to the compelling correlations between atherosclerosis and separated blood flow in this region, and different studies have used particle tracking to better understand flow features in this region [111, 137, 139, 142, 92]. The effect of non-Newtonian blood rheology on tracer paths has been investigated in a 2D stenosis model [20], and in a 2D slice of an aneurysm where velocities were obtained from particle image velocimetry (PIV) [37]. Lagrangian particle tracking has also been used in evaluating surgical and device design, including optimal flow distribution in the design for the Fontan surgery [91, 157, 156].…”

Section: Modeling Advection From Velocity Datamentioning

confidence: 99%

Lagrangian Postprocessing of Computational Hemodynamics

Shadden

Arzani

2014

Ann Biomed Eng

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Recent advances in imaging, modeling and computing have rapidly expanded our capabilities to model hemodynamics in the large vessels (heart, arteries and veins). This data encodes a wealth of information that is often under-utilized. Modeling (and measuring) blood flow in the large vessels typically amounts to solving for the time-varying velocity field in a region of interest. Flow in the heart and larger arteries is often complex, and velocity field data provides a starting point for investigating the hemodynamics. This data can be used to perform Lagrangian particle tracking, and other Lagrangian-based postprocessing. As described herein, Lagrangian methods are necessary to understand inherently transient hemodynamic conditions from the fluid mechanics perspective, and to properly understand the biomechanical factors that lead to acute and gradual changes of vascular function and health. The goal of the present paper is to review Lagrangian methods that have been used in post-processing velocity data of cardiovascular flows.

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Flow of a blood analogue fluid in a compliant abdominal aortic aneurysm model: Experimental modelling

Cited by 46 publications

References 24 publications

Accounting for residence-time in blood rheology models: do we really need non-Newtonian blood flow modelling in large arteries?

Accounting for residence-time in blood rheology models: do we really need non-Newtonian blood flow modelling in large arteries?

In vitro particulate analogue fluids for experimental studies of rheological and hemorheological behavior of glucose-rich RBC suspensions

Lagrangian Postprocessing of Computational Hemodynamics

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