Quality control of piezoelectric micropumps is presented through design, fabrication process, operation, and characterization. The presented study resulted in the extraction of a minimal set of monitored parameters, which is a prerequisite for reliable and stable micropump operation. Micropump fabrication process steps, especially bonding process quality, in correlation with quality control of micropump constituent components (housing, elastomer, and piezoelectric actuator) provided an explanation for deterioration of common micropump characteristics, such as flow vs. backpressure, suction pressure, and excitation signal. These characteristics also manifested in deterioration of other important micropump properties, such as self-priming ability, bubble tolerance, long-term stability, heat dissipation, and temperature operating range. Besides air and DI water pumping, chemical compatibility of constituent materials was confirmed during successful long-term testing of micropumps by pumping media with different viscosity and aggressive media with low pH value. The extracted set of parameters defines input control for micropump fabrication process while at the same time establishes safe operating area of fabricated micropumps. The presented set of parameters provides quality control guidelines and enables a direct comparison from pump-to-pump or run-to-run variations and extraction of influencing design or fabrication parameters.