Flow-through sensor with Fourier transform Raman detection for determination of sulfonamides

Abstract

A flow-through sensor system with Fourier transform (FT) Raman spectroscopy as detection technique is described. The molecular and structural information contained in Raman spectra together with the selective retention of the species of interest on the sorbent make the proposed methodology highly selective. The flow-through sensor allowed the direct quantitative determination of sulfathiazole and sulfamethoxazole in the presence of other species that are normally encountered with these analytes. The system used Sephadex QAE A-25 resin as packing material of a flow-through cell on which sulfonamides were temporarily retained. Samples were transported by a carrier solution of NaOH 10(-2) mol l(-1) (pH = 12), and 2 ml of a [NaCl (0.10 mol l(-1))/NaOH (10(-2) mol l(-1))] solution was employed as eluent. Using a sample volume of 1 ml, the analytical signal was linear in the range 0.5-7 g l(-1) and 0.5-10 g l(-1), for sulfathiazole and sulfamethoxazole, respectively. RSDs (%) lower than 4% were obtained for both analytes. The sensor was satisfactorily applied to several commercial pharmaceutical preparations for human and animals in different physical presentations, including capsules, syrup, tablets, powders, injectables and suspensions.

Binding Mechanism and Surface-Enhanced Raman Scattering of the Antimicrobial Sulfathiazole on Gold Nanoparticles

“…A slight shift of the peak position is observed in the spectra of solution samples compared to that of the solid sulfathiazole (Figure a–c). The sharp peak located at 1583 cm –1 is attributed to the stretching vibration of the benzene ring. , Moreover, the peak of 1142 cm –1 is attributed to the SO 2 group in the molecular structure of sulfa-thiazole. , The peak centered at 1585 cm –1 is selected to detect sulfathiazole using the small-sized AuNPs substrate. Besides, the peak located at 732 cm –1 only appears in the spectrum of sulfathiazole solid substances (Figure b).…”

“…25,26 Moreover, the peak of 1142 cm −1 is attributed to the SO 2 group in the molecular structure of sulfa-thiazole. 27,28 The peak centered at 1585 cm −1 is selected to detect sulfathiazole using the small-sized AuNPs substrate. Besides, the peak located at 732 cm −1 only appears in the spectrum of sulfathiazole solid substances (Figure 2b).…”

Spectrophotometric method for the Determination of Sulfathiazole Drug by Schiff's base Formation

“…(3,4) Soluble 1g in 2500 ml of water and 1g in 120 ml of ethanol; practically insoluble in chloroform and ether; soluble in acetone.The drug is used as an anti-bacterial (4,5) . Many different analytical methods were used for the determination of sulfathiazole such as spectrophotometric methods (6)(7)(8)(9) , high performance liquid chromatographic methods (HPLC) (10)(11)(12)(13)(14)(15)(16)(17)(18) , electrochemical method (19)(20) , chemiluminescence method (21) , flow-injection method (22)(23) , FT-Raman technique (24)(25) and gas-liquid chromatographic method (GLC) (26) . In this research a simple, accurate and sensitive spectrophotometric method for determining of sulfathiazole in pure form as well as in veterinary injection liquid solution (bioprime) based on the formation of Schiff's base using pdimethylaminobenzaldehyde reagent.…”

Fast Determination of Salicylic Acid in Pharmaceuticals by Using a Terbium-Sensitized Luminescent SIA Optosensor

“…UV–VIS spectroscopy and fluorescence have traditionally been the main detection techniques used when developing flow‐through optosensing, although other detection techniques also show outstanding features 14, 15. Terbium‐sensitized luminescence is an interesting detection technique due to its particular features, but it has been rarely described in optosensing 16, 17.…”