Flow velocity estimation using joint Spectral and Time domain Optical Coherence Tomography

Szkulmowski, Maciej; Szkulmowska, Anna; Bajraszewski, Tomasz; Kowalczyk, Andrzej; Wojtkowski, Maciej

doi:10.1364/oe.16.006008

Cited by 157 publications

(133 citation statements)

References 24 publications

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“…129,130 The latter is of particular importance for high-quality vessel contrasting against static bulk tissue in many angiography approaches. Furthermore, high speed enables specific Doppler analysis methods, 131 enhanced velocity bandwidth, 132,133 as well as the possibility of using flexible scanning patterns to further increase the velocity sensitivity. 134,135 In general, flow contrasting requires comparing two or more scans preferably taken at the same location.…”

Section: Label-free Optical Angiographymentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

432

264

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Abstract. In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and full-field OCT, has shortened the acquisition time even further by establishing quasi-akinetic scanning. Besides the technical improvements, several functional and contrast-enhancing OCT applications have been investigated, among which the label-free angiography shows great potential for future studies. Finally, various multimodal imaging modalities with OCT incorporated are reviewed, in that these multimodal implementations can synergistically compensate for the fundamental limitations of OCT when it is used alone. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Label-free Optical Angiographymentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

432

264

View full text Add to dashboard Cite

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“…The last column in the Table 1 shows effective sensitivity values taking into account both effects: the shortening of the signal integration time and the truncation of the spectrum. To double the axial measurement range (up to 10 mm) we have implemented a technique of complex conjugate images removal [45] based on a joint Spectral and Time domain OCT (STdOCT) concept previously demonstrated to flow analysis [7,45,46]. Our technique requires the optical path difference (OPD) between the arms of the interferometer to be varied at a constant rate during the acquisition of the interferometric signal.…”

Section: The Soct Instrumentmentioning

confidence: 99%

“…The computation time is longer, but this drawback can be compensated by an increase in sensitivity caused by more efficient averaging of the noise floor [7,45].…”

Section: The Soct Instrumentmentioning

confidence: 99%

“…OCT technique enables two-or three-dimensional (2-D or 3-D) cross-sectional imaging with micrometer resolution [1][2][3][4]. Besides morphology, OCT reveals and visualizes such properties of biological objects as velocity of flow (via Doppler effect), birefringence (via polarization changes) and tissue extinction [5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anterior segment imaging with Spectral OCT system using a high-speed CMOS camera

Grulkowski¹,

Gora²,

Szkulmowski³

et al. 2009

Opt. Express

Self Cite

154

124

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Abstract:We describe a new ultrahigh speed Spectral OCT instrument making use of a CMOS camera and demonstrate high quality in vivo imaging of the anterior segment of the human eye. The high flexibility of the designed imaging system allows a wide range of imaging protocols. Two-and three-dimensional high quality OCT images of the cornea, the anterior chamber and the crystalline lens are presented. A high acquisition rate, up to 135,000 A-scans/second enables three-dimensional reconstruction of the anterior segment during lenticular accommodation, blinking and pupillary reaction to light stimulus. We demonstrate OCT tomographic real time imaging of the lens dynamics during accommodation and high quality OCT cross-sectional images of the entire anterior segment of the eye from the cornea up to posterior part of the crystalline lens. 2009 Optical Society of America

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“…The measured flow fluctuates slowly with ~10% in time. For this flow rate and Doppler angle we obtain a laminar flow with a Doppler frequency far below the maximum Doppler frequency (<13% of half the maximum A-line rate) to avoid phase-wrapping, non-linear effects [18], and/or an underestimation of the flow [19].…”

Section: Doppler Optical Coherence Tomographymentioning

confidence: 99%

Multiple and dependent scattering effects in Doppler optical coherence tomography

et al. 2010

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Doppler optical coherence tomography (OCT) is a technique to image tissue morphology and to measure flow in turbid media. In its most basic form, it is based on single (Mie) scattering. However, for highly scattering and dense media multiple and concentration dependent scattering can occur. For Intralipid solutions with varying scattering strength, the effect of multiple and dependent scattering on the OCT signal attenuation and Doppler flow is investigated. We observe a non-linear increase in the OCT signal attenuation rate and an increasingly more distorted Doppler OCT flow profile with increasing Intralipid concentration. The Doppler OCT attenuation and flow measurements are compared to Monte Carlo simulations and good agreement is observed. Based on this comparison, we determine that the single scattering attenuation coefficient µ s is 15% higher than the measured OCT signal attenuation rate. This effect and the distortion of the measured flow profile are caused by multiple scattering. The non-linear behavior of the single scattering attenuation coefficient with Intralipid concentration is attributed to concentration dependent scattering.

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Flow velocity estimation using joint Spectral and Time domain Optical Coherence Tomography

Cited by 157 publications

References 24 publications

Optical coherence tomography today: speed, contrast, and multimodality

Optical coherence tomography today: speed, contrast, and multimodality

Anterior segment imaging with Spectral OCT system using a high-speed CMOS camera

Multiple and dependent scattering effects in Doppler optical coherence tomography

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