Fluctuations in CA 125 and CA 15 3 serum concentrations during spontaneous ovulatory cycles

Bon, Gijsbert G.; Kenemans, P.; Dekker, Jacqueline; Hompes, P.G.A.; Verstraeten, Rob A.; Kamp, Gerard J. van; Schoemaker, J.

doi:10.1093/humrep/14.2.566

Cited by 67 publications

(48 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…18,19 The CA125 released by the endometrium may reach the blood stream and lymphatic circulation via the peritoneal route, starting from retrograde menstruation, thereby allowing contact with local inflammatory reactions and thus releasing coelomic CA125. 20 Another explanation for the increased levels of CA125 in the bloodstream could be its access into the abdominal cavity through tubal reflux, thus resulting in absorption by peritoneal lymphatic vessels. Despite the mechanisms proposed, doubts still persist about the real mechanism of CA125 release into the circulation, considering that retrograde menstruation is still controversial and that the levels of this marker change during the postmenopausal period.…”

Section: Discussionmentioning

confidence: 99%

Frequency of endometriotic lesions in peritoneum samples from asymptomatic fertile women and correlation with CA125 values

et al. 2009

View full text Add to dashboard Cite

CONTEXT AND OBJECTIVE: Serological testing for CA125 has been widely used to detect endometriosis and to monitor its progression. However, controversy still exists regarding the usefulness of the plasma CA125 assay for diagnosing endometriosis. Furthermore, some authors have described superficial endometriosis as a cyclical and normal phenomenon in women's lives, and have indicated that development and progression of this disease would only occur in some women as a result of immunological changes. This study aimed to determine the frequency of endometriosis and the correlation between serum CA125 levels and the presence of endometriotic lesions in the peritoneum of asymptomatic fertile patients. DESIGN AND SETTING:Cross-sectional study at the Family Planning outpatient clinic of Faculdade de Medicina do ABC. METHODS:Eighty asymptomatic fertile patients who underwent tubal sterilization surgery were studied. Blood and peritoneum samples were collected. CA125 levels were measured from blood samples, and peritoneum biopsies were studied using histopathological tests. RESULTS:Histopathological evaluation of the peritoneum revealed that 16.25% of the patients had minimal or mild endometriosis. There was no statistically significant difference in CA125 levels between patients with and without endometriosis. CONCLUSION:The presence of endometriotic lesions in the peritoneum of fertile patients supports the hypothesis that incidental findings of minimal or mild endometriosis may not be of clinical significance, and that the progression of the disease probably occurs as a result of immunological and genetic abnormalities. Serum CA125 levels did not show any diagnostic significance with regard to detecting the disease.RESUMO CONTEXTO E OBJETIVO: O teste sorológico para CA125 tem sido largamente usado para detectar e monitorar a progressão da endometriose, entretanto, a utilidade do ensaio do CA125 plasmático para o diagnóstico da endometriose ainda é controversa. Além disso, alguns autores descreveram a endometriose superficial como sendo um fenômeno cíclico e normal na vida de uma mulher, e que o desenvolvimento e progressão desta doença ocorreriam apenas em algumas mulheres como resultado de alterações imunológicas. Este estudo teve como objetivo determinar a freqüência de endometriose e a correlação entre os níveis séricos de CA125 e a presença de lesões endometrióticas em peritônio de pacientes férteis assintomáticas. TIPO DE ESTUDO E LOCAL: Estudo transversal realizado no Ambulatório de Planejamento Familiar da Faculdade de Medicina do ABC.MÉTODOS: Foram estudadas 80 pacientes férteis assintomáticas submetidas à cirurgia de esterilização tubária. Amostras de sangue e peritônio foram coletadas. Os níveis de CA125 foram medidos a partir das amostras de sangue e as biópsias de peritônio foram estudadas por ensaio histopatológico. RESULTADOS:O estudo histopatológico do peritônio revelou que 16,25% das pacientes apresentavam endometriose mínima e leve. Os níveis de CA125 não demonstraram diferença estatística sign...

show abstract

Section: Discussionmentioning

confidence: 99%

Frequency of endometriotic lesions in peritoneum samples from asymptomatic fertile women and correlation with CA125 values

et al. 2009

View full text Add to dashboard Cite

show abstract

“…However, a functional rather than quantitative change of the endometrium still may be at the origin of CA-125 changes (7). Observations reported in the literature agree that CA-125 levels rise during the menstrual period as a consequence of endometrial disruption (18,19). This is probably due to an easier access of CA-125 from the endometrial epithelial lining into the circulation during menstruation (20).…”

Section: Discussionmentioning

confidence: 79%

Prognostic value of serum CA-125 measurements on stimulation day 1 and on the day of oocyte pickup in the prediction of IVF treatment outcome

Hauzman

Lagarde

Nagy

et al. 2005

J Assist Reprod Genet

View full text Add to dashboard Cite

“…Some hypotheses tried to explain this increase: presence of blood and eutopic endometrial tissue into the peritoneal cavity due to retrograde menses, enlarged surface of endometrial tissue, and inflammatory reaction in the endometrial foci [18]. Bon et al suggested that CA-125 released from the endometrium can have access to the lymphatics and the circulation [19].…”

Section: Discussionmentioning

confidence: 99%

How to use CA-125 More Effectively in the Diagnosis of Deep Endometriosis?

Raymundo

Oliveira

Soares

et al. 2017

Journal of Minimally Invasive Gynecology

View full text Add to dashboard Cite

Deep infiltrative endometriosis (DIE) is a severe form of the disease. The median time interval from the onset of symptoms to diagnosis of endometriosis is around 8 years. In this prospective study patients were divided into two groups: cases (34 DIE patients) and control (20 tubal ligation patients). The main objective of this study was to evaluate the performance of CA-125 measurement in the menstrual and midcycle phases of the cycle, as well as the difference in its levels between the two phases, for the early diagnosis of DIE. Area Under the Curve (AUC) of CA-125 in menstrual phase and of the difference between menstrual and midcycle phases had the best performance (both with AUC = 0.96), followed by CA-125 in the midcycle (AUC = 0.89). The ratio between menstrual and midcycle phases had the worst performance. CA-125 may be useful for the diagnosis of deep endometriosis, especially when both are collected during menstruation and in midcycle. These may help to decrease the long interval until the definitive diagnosis of DIE. Multicentric studies with larger samples should be performed to better evaluate the cost-effectiveness of measuring CA-125 in two different phases of the menstrual cycle.

show abstract

Fluctuations in CA 125 and CA 15 3 serum concentrations during spontaneous ovulatory cycles

Cited by 67 publications

References 24 publications

Frequency of endometriotic lesions in peritoneum samples from asymptomatic fertile women and correlation with CA125 values

Frequency of endometriotic lesions in peritoneum samples from asymptomatic fertile women and correlation with CA125 values

Prognostic value of serum CA-125 measurements on stimulation day 1 and on the day of oocyte pickup in the prediction of IVF treatment outcome

How to use CA-125 More Effectively in the Diagnosis of Deep Endometriosis?

Contact Info

Product

Resources

About