Fluctuations in cellular proliferation across the light/dark cycle in the subgranular zone of the dentate gyrus in the adult male Syrian hamster

Smith, Jeannie Marie; Hechtman, Aaron; Swann, Jennifer M.

doi:10.1016/j.neulet.2010.02.039

Cited by 13 publications

(10 citation statements)

References 24 publications

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“…There is a circadian rhythm in proliferation [37]. The period of the cell cycle in neural stem/progenitor cells (NSPCs) is approximately a day [38].…”

Section: Discussionmentioning

confidence: 99%

Survival of Adult Generated Hippocampal Neurons Is Altered in Circadian Arrhythmic Mice

et al. 2014

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The subgranular zone of the hippocampal formation gives rise to new neurons that populate the dentate gyrus throughout life. Cells in the hippocampus exhibit rhythmic clock gene expression and the circadian clock is known to regulate the cycle of cell division in other areas of the body. These facts suggest that the circadian clock may regulate adult neurogenesis in the hippocampus as well. In the present study, neurogenesis in the hippocampal subgranular zone was examined in arrhythmic Bmal1 knockout (-KO) mice and their rhythmic heterozygous and wildtype littermates. Proliferation and survival of newly generated subgranular zone cells were examined using bromodeoxyuridine labelling, while pyknosis (a measure of cell death) and hippocampal volume were examined in cresyl violet stained sections. There was no significant difference in cellular proliferation between any of the groups, yet survival of proliferating cells, 6 weeks after the bromodeoxyuridine injection, was significantly greater in the BMAL1-KO animals. The number of pyknotic cells was significantly decreased in Bmal1-KO animals, yet hippocampal volume remained the same across genotypes. These findings suggest that while a functional circadian clock is not necessary for normal proliferation of neuronal precursor cells, the normal pruning of newly generated neurons in the hippocampus may require a functional circadian clock.

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“…There is a circadian rhythm in proliferation [37]. The period of the cell cycle in neural stem/progenitor cells (NSPCs) is approximately a day [38].…”

Section: Discussionmentioning

confidence: 99%

Survival of Adult Generated Hippocampal Neurons Is Altered in Circadian Arrhythmic Mice

et al. 2014

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“…Although an area not classically associated with circadian timing, it seems that clock genes are expressed rhythmically in the DG (Jilg et al, 2010), including hippocampal neural progenitor cells, in which they may generate proliferative rhythms and regulate differentiation into mature neurons (Borgs et al, 2009;Gilhooley et al, 2011;Kimiwada et al, 2009;Smith et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

The primate seahorse rhythm

2015

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“…In the SGZ, clock genes and NPC proliferation shows daily rhythms which persist in constant darkness, thus circadian [ 177 ]. Hippocampal NPC proliferation fluctuates across the light/dark phases in hamsters [ 178 ] and mice, with higher proliferation levels in the night/active phase than in the day/inactive phase under a standard photoperiod [ 179 ], and constant darkness [ 177 ]. These rhythms are abolished in mice with mutations/deletions of Bmal1, Per2 [ 177 ], or Rev-erbα [ 179 ], thus dependent on a functional molecular clockwork.…”

Section: Interaction Of the Circadian System And Adult Neurogenesismentioning

confidence: 99%

Adult Neurogenesis under Control of the Circadian System

Ali

Gall

2022

Cells

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The mammalian circadian system is a hierarchically organized system, which controls a 24-h periodicity in a wide variety of body and brain functions and physiological processes. There is increasing evidence that the circadian system modulates the complex multistep process of adult neurogenesis, which is crucial for brain plasticity. This modulatory effect may be exercised via rhythmic systemic factors including neurotransmitters, hormones and neurotrophic factors as well as rhythmic behavior and physiology or via intrinsic factors within the neural progenitor cells such as the redox state and clock genes/molecular clockwork. In this review, we discuss the role of the circadian system for adult neurogenesis at both the systemic and the cellular levels. Better understanding of the role of the circadian system in modulation of adult neurogenesis can help develop new treatment strategies to improve the cognitive deterioration associated with chronodisruption due to detrimental light regimes or neurodegenerative diseases.

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Fluctuations in cellular proliferation across the light/dark cycle in the subgranular zone of the dentate gyrus in the adult male Syrian hamster

Cited by 13 publications

References 24 publications

Survival of Adult Generated Hippocampal Neurons Is Altered in Circadian Arrhythmic Mice

Survival of Adult Generated Hippocampal Neurons Is Altered in Circadian Arrhythmic Mice

The primate seahorse rhythm

Adult Neurogenesis under Control of the Circadian System

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