Fluidity of cadaveric blood after sudden death: Part II

Takeichi, Sanae; Wakasugi, Choei; Shikata, Ichiro

doi:10.1097/00000433-198503000-00006

Cited by 30 publications

(15 citation statements)

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“…Platelets and serum proteins retain their normal function a few hours after blood cessation; afterwards stasis, hypoxia, decreased pH, and endothelial alterations lead to the formation of postmortem blood cloths concomitant with fibrinolysis processes (19,20). In deaths in which increased levels of catecholamine or plasminogen activator are released in the agonal period (as is the case with most sudden deaths) the thrombolytic events are increased and the cadaveric blood is liquid; if the agonal period is prolonged thrombotic events are dominant, leading to an increased density of postmortem clots (21)(22)(23). For this reason we could not perform coagulation tests, that might have revealed the presence of additional risk factors for thromboembolism.…”

Section: Casementioning

confidence: 99%

Lethal pulmonary thromboembolism associated with decreased thyroid hormone levels

Hostiuc

Capatina²,

Sinescu

et al. 2015

Arch. Endocrinol. Metab.

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SUMMARYThyroid pathology is rarely involved in the pathogenesis of sudden death in young people. We report here the cases of two young patients with decreased levels of thyroid hormones whose death was caused by an increased thrombotic status, with venous thrombosis and pulmonary thromboembolism. In both cases the thyroid pathology was not considered as the underlying cause of death as the association between this condition and venous thrombosis is still debatable. However its presence may be considered a circumstantial factor, which could increase the severity of the disease and subsequently the lethality rate in pulmonary thromboembolism. An increased awareness for hypothyroidism or subclinical hypothyroidism in clinical practice may lead to a decrease in mortality secondary to thromboembolic disease. Also, increased awareness for thyroid pathology during forensic autopsy in sudden deaths may lead to potentially significant results, that could explain some of the sudden death with an unknown cause, and decrease the number of the so called blank autopsies. Arch Endocrinol Metab. 2015;59(4):355-8

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Section: Casementioning

confidence: 99%

Lethal pulmonary thromboembolism associated with decreased thyroid hormone levels

Hostiuc

Capatina²,

Sinescu

et al. 2015

Arch. Endocrinol. Metab.

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“…Advanced atherosclerotic coronary disease is often co-existent, although little or no coronary atherosclerosis was detected in approximately half of the sudden cardiac death cases. In some cases, extremely acute ischemic changes of the myocardium were observed only with microscopically attentive examination, suggesting the possibility of antemortem spasm of coronary stem and disappearance of the coronary thrombus due to the enhanced postmortem fibrinolytic activity [2][3][4]. Some components in the blood seem to induce the coronary spasm and/or thrombogenesis under certain conditions, which does not necessarily relate with the severity of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

The possible role of remnant-like particles as a risk factor for sudden cardiac death

Takeichi

Nakajima

Osawa

et al. 1997

International Journal of Legal Medicine

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Postmortem plasma lipid and lipoprotein levels were analyzed in two groups of Japanese subjects who died suddenly and unexpectedly due to cardiac (n = 93) or non-cardiac (n = 26) causes. No individuals in either group had a significant medical or cardiac history. In this study, we measured plasma total cholesterol, triglycerides, VLDL-cholesterol, LDL-cholesterol, HDL-cholesterol, and especially triglyceride-rich lipoprotein remnants. Triglyceride and apo E-rich remnant-like particles (RLP) were studied as a possible risk factor for sudden cardiac death in relation to the progression of coronary atherosclerosis. The receiver-operating characteristic curve (ROC) analysis showed that RLP-TG was the most significant risk factor for sudden cardiac death among the lipids and lipoproteins and RLP-C was the best predictor for coronary atherosclerosis. HDL-C and LDL-C levels were within normal limits in the majority of the cases and did not appear to relate to the sudden cardiac death. Apo E phenotyping was performed for the detection of the genetic background in the lipid metabolism. The frequency of the Apo E3/3 (wild type) phenotype, which closely relates with the remnant metabolism, was significantly reduced in the sudden cardiac death group. Our study on the postmortem plasma lipid analysis suggested that RLP-C and RLP-TG are the best risk predictor for coronary atherosclerosis and sudden cardiac death, respectively.

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“…In our opinion, the latter explanation is the most plausible, because high levels of catecholamines and low pH, as often seen in these (TE 96 ms, TR 4,000 ms). Note the hyperdensities in the lower areas of the right upper pulmonary lobe (small arrow) in contrast to the hypodensities of the upper parts (large arrow) and to the right lower lobe below; on coronal T2-weighted MR images, internal livores appear hypointense in contrast to other parenchymal organs (upper arrow) cases, induce fibrinolysis by increasing the release of plasminogen activator from the vascular wall [27][28][29]. Supporting this explanation is the experience that clotting mostly begins within the cardiac cavities and the major vessels.…”

Section: Postmortem Clottingmentioning

confidence: 99%

Postmortem imaging of blood and its characteristics using MSCT and MRI

et al. 2005

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The rapid development of computed tomography (CT) and magnetic resonance imaging (MRI) led to the introduction and establishment in postmortem investigations. The objectives of this preliminary study were to describe the imaging appearances of the early postmortem changes of blood after cessation of the circulation, such as sedimentation, postmortem clotting, and internal livores, and to give a few first suggestions on how to differentiate them from other forensic findings. In the Virtopsy project, 95 human corpses underwent postmortem imaging by CT and MRI prior to traditional autopsy and therefore 44 cases have been investigated in this study. Postmortem alterations as well as the forensic relevant findings of the blood, such as internal or subcutaneous bleedings, are presented on the basis of their imaging appearances in multislice CT and MRI.

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Fluidity of cadaveric blood after sudden death: Part II

Cited by 30 publications

References 0 publications

Lethal pulmonary thromboembolism associated with decreased thyroid hormone levels

Lethal pulmonary thromboembolism associated with decreased thyroid hormone levels

The possible role of remnant-like particles as a risk factor for sudden cardiac death

Postmortem imaging of blood and its characteristics using MSCT and MRI

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