Flunarizine-loaded microparticles for the prophylaxis of migraine

Evaluating the effect of synthesis, isolation, and characterisation variables on reported particle size and dispersity of drug loaded PLGA nanoparticles

“…1,[4][5][6][7][8] There are many examples in the literature using PLGA-based materials for delivery of therapeutics to promote either fast or prolonged drug release with applications in cancer treatment, pain management, immunotherapy, and more recently, in the treatment of pulmonary tuberculosis, urinary tract infections, migraine and glaucoma. 5,6,[9][10][11][12][13][14][15] There are several techniques that are used for the preparation of PLGA particles including single and double emulsion solvent evaporation (ESE), nanoprecipitation, spray-drying, microfluidics, and hydrogel templating. 2,[16][17][18][19] These techniques enable the synthesis of a wide range of PLGA nano-and sub-micron sized particles.…”

“…1,4–8 There are many examples in the literature using PLGA-based materials for delivery of therapeutics to promote either fast or prolonged drug release with applications in cancer treatment, pain management, immunotherapy, and more recently, in the treatment of pulmonary tuberculosis, urinary tract infections, migraine and glaucoma. 5,6,9–15…”

Scalable production of microscopic particles for biological delivery

“…[158][159][160][161] However, there have also been publications reporting that gamma irradiation caused no significant changes to PLGA particle-based drug formulations. 161,162 If gamma irradiation, ultraviolet light, and autoclaving are found to be problematic, an alternative method can be sterile filtration of the final product. Nevertheless, this process only works for nanoformulations with a size distribution smaller than 0.22 mm.…”